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Items: 1 to 20 of 62

1.

Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis.

Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y, Brenner DA.

Gastroenterology. 2009 Apr;136(4):1423-34. doi: 10.1053/j.gastro.2008.12.064. Epub 2009 Jan 6.

PMID:
19249395
2.

Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes.

Vick B, Weber A, Urbanik T, Maass T, Teufel A, Krammer PH, Opferman JT, Schuchmann M, Galle PR, Schulze-Bergkamen H.

Hepatology. 2009 Feb;49(2):627-36. doi: 10.1002/hep.22664.

3.

Overexpression of mcl-1 attenuates liver injury and fibrosis in the bile duct-ligated mouse.

Kahraman A, Mott JL, Bronk SF, Werneburg NW, Barreyro FJ, Guicciardi ME, Akazawa Y, Braley K, Craig RW, Gores GJ.

Dig Dis Sci. 2009 Sep;54(9):1908-17. doi: 10.1007/s10620-008-0583-5. Epub 2008 Dec 3.

4.

BAX activation is initiated at a novel interaction site.

Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD.

Nature. 2008 Oct 23;455(7216):1076-81. doi: 10.1038/nature07396.

5.

Insulin sensitivity: modulation by nutrients and inflammation.

Schenk S, Saberi M, Olefsky JM.

J Clin Invest. 2008 Sep;118(9):2992-3002. doi: 10.1172/JCI34260. Review.

6.

Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia.

Doege H, Grimm D, Falcon A, Tsang B, Storm TA, Xu H, Ortegon AM, Kazantzis M, Kay MA, Stahl A.

J Biol Chem. 2008 Aug 8;283(32):22186-92. doi: 10.1074/jbc.M803510200. Epub 2008 Jun 3.

7.

The role of fatty acids in the development and progression of nonalcoholic fatty liver disease.

Gentile CL, Pagliassotti MJ.

J Nutr Biochem. 2008 Sep;19(9):567-76. doi: 10.1016/j.jnutbio.2007.10.001. Epub 2008 Apr 21. Review.

8.

Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum.

Sakaki K, Wu J, Kaufman RJ.

J Biol Chem. 2008 May 30;283(22):15370-80. doi: 10.1074/jbc.M710209200. Epub 2008 Mar 20.

9.

Unique biology of Mcl-1: therapeutic opportunities in cancer.

Warr MR, Shore GC.

Curr Mol Med. 2008 Mar;8(2):138-47. Review.

PMID:
18336294
10.

Hepatic free fatty acids accumulate in experimental steatohepatitis: role of adaptive pathways.

Larter CZ, Yeh MM, Haigh WG, Williams J, Brown S, Bell-Anderson KS, Lee SP, Farrell GC.

J Hepatol. 2008 Apr;48(4):638-47. doi: 10.1016/j.jhep.2007.12.011. Epub 2008 Jan 28.

PMID:
18280001
11.

Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis.

Zhou J, Febbraio M, Wada T, Zhai Y, Kuruba R, He J, Lee JH, Khadem S, Ren S, Li S, Silverstein RL, Xie W.

Gastroenterology. 2008 Feb;134(2):556-67. doi: 10.1053/j.gastro.2007.11.037. Epub 2007 Nov 28.

PMID:
18242221
12.

Muscular diacylglycerol metabolism and insulin resistance.

Timmers S, Schrauwen P, de Vogel J.

Physiol Behav. 2008 May 23;94(2):242-51. doi: 10.1016/j.physbeh.2007.12.002. Epub 2007 Dec 14. Review.

PMID:
18207474
13.

The BCL-2 protein family: opposing activities that mediate cell death.

Youle RJ, Strasser A.

Nat Rev Mol Cell Biol. 2008 Jan;9(1):47-59. Review.

PMID:
18097445
14.

Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization.

Meng XW, Lee SH, Dai H, Loegering D, Yu C, Flatten K, Schneider P, Dai NT, Kumar SK, Smith BD, Karp JE, Adjei AA, Kaufmann SH.

J Biol Chem. 2007 Oct 12;282(41):29831-46. Epub 2007 Aug 13.

15.

A lipidomic analysis of nonalcoholic fatty liver disease.

Puri P, Baillie RA, Wiest MM, Mirshahi F, Choudhury J, Cheung O, Sargeant C, Contos MJ, Sanyal AJ.

Hepatology. 2007 Oct;46(4):1081-90.

PMID:
17654743
16.

Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis.

Barreyro FJ, Kobayashi S, Bronk SF, Werneburg NW, Malhi H, Gores GJ.

J Biol Chem. 2007 Sep 14;282(37):27141-54. Epub 2007 Jul 11.

17.

Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease.

Parekh S, Anania FA.

Gastroenterology. 2007 May;132(6):2191-207. Review.

PMID:
17498512
18.

Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.

Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, Bhanot S, Monia BP, Li YX, Diehl AM.

Hepatology. 2007 Jun;45(6):1366-74.

PMID:
17476695
19.

Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity.

Malhi H, Barreyro FJ, Isomoto H, Bronk SF, Gores GJ.

Gut. 2007 Aug;56(8):1124-31. Epub 2007 Apr 30.

20.

Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1.

Kobayashi S, Lee SH, Meng XW, Mott JL, Bronk SF, Werneburg NW, Craig RW, Kaufmann SH, Gores GJ.

J Biol Chem. 2007 Jun 22;282(25):18407-17. Epub 2007 Apr 25.

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