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Abnormal skin barrier in the etiopathogenesis of atopic dermatitis.

Elias PM, Schmuth M.

Curr Allergy Asthma Rep. 2009 Jul;9(4):265-72. Review.


A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming.

Fallon PG, Sasaki T, Sandilands A, Campbell LE, Saunders SP, Mangan NE, Callanan JJ, Kawasaki H, Shiohama A, Kubo A, Sundberg JP, Presland RB, Fleckman P, Shimizu N, Kudoh J, Irvine AD, Amagai M, McLean WH.

Nat Genet. 2009 May;41(5):602-8. doi: 10.1038/ng.358. Epub 2009 Apr 6.


pH-regulated mechanisms account for pigment-type differences in epidermal barrier function.

Gunathilake R, Schurer NY, Shoo BA, Celli A, Hachem JP, Crumrine D, Sirimanna G, Feingold KR, Mauro TM, Elias PM.

J Invest Dermatol. 2009 Jul;129(7):1719-29. doi: 10.1038/jid.2008.442. Epub 2009 Jan 29.


Atopic dermatitis: therapeutic concepts evolving from new pathophysiologic insights.

Jung T, Stingl G.

J Allergy Clin Immunol. 2008 Dec;122(6):1074-81. doi: 10.1016/j.jaci.2008.09.042. Epub 2008 Nov 6. Review.


Clinical severity correlates with impaired barrier in filaggrin-related eczema.

Nemoto-Hasebe I, Akiyama M, Nomura T, Sandilands A, McLean WH, Shimizu H.

J Invest Dermatol. 2009 Mar;129(3):682-9. doi: 10.1038/jid.2008.280. Epub 2008 Sep 25.


"Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis.

Elias PM, Steinhoff M.

J Invest Dermatol. 2008 May;128(5):1067-70. doi: 10.1038/jid.2008.88. Review.


Modeling atopic dermatitis with increasingly complex mouse models.

Scharschmidt TC, Segre JA.

J Invest Dermatol. 2008 May;128(5):1061-4. doi: 10.1038/sj.jid.5701201. Review.


Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms.

Elias PM, Hatano Y, Williams ML.

J Allergy Clin Immunol. 2008 Jun;121(6):1337-43. doi: 10.1016/j.jaci.2008.01.022. Epub 2008 Mar 7. Review.


Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism.

Elias PM, Williams ML, Holleran WM, Jiang YJ, Schmuth M.

J Lipid Res. 2008 Apr;49(4):697-714. doi: 10.1194/jlr.R800002-JLR200. Epub 2008 Feb 2. Review.


Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology.

Schmuth M, Jiang YJ, Dubrac S, Elias PM, Feingold KR.

J Lipid Res. 2008 Mar;49(3):499-509. doi: 10.1194/jlr.R800001-JLR200. Epub 2008 Jan 8. Review.


Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema.

Brown SJ, Sandilands A, Zhao Y, Liao H, Relton CL, Meggitt SJ, Trembath RC, Barker JN, Reynolds NJ, Cordell HJ, McLean WH.

J Invest Dermatol. 2008 Jun;128(6):1591-4. Epub 2007 Dec 20. No abstract available.


Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel.

Novak N, Baurecht H, Schäfer T, Rodriguez E, Wagenpfeil S, Klopp N, Heinrich J, Behrendt H, Ring J, Wichmann E, Illig T, Weidinger S.

J Invest Dermatol. 2008 Jun;128(6):1430-5. Epub 2007 Nov 29.


Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice.

Aberg KM, Radek KA, Choi EH, Kim DK, Demerjian M, Hupe M, Kerbleski J, Gallo RL, Ganz T, Mauro T, Feingold KR, Elias PM.

J Clin Invest. 2007 Nov;117(11):3339-49.


Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation.

Man MQ, Barish GD, Schmuth M, Crumrine D, Barak Y, Chang S, Jiang Y, Evans RM, Elias PM, Feingold KR.

J Invest Dermatol. 2008 Feb;128(2):370-7. Epub 2007 Aug 23.


Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges.

Man MQ, Hatano Y, Lee SH, Man M, Chang S, Feingold KR, Leung DY, Holleran W, Uchida Y, Elias PM.

J Invest Dermatol. 2008 Jan;128(1):79-86. Epub 2007 Aug 2.


Stratum corneum acidification is impaired in moderately aged human and murine skin.

Choi EH, Man MQ, Xu P, Xin S, Liu Z, Crumrine DA, Jiang YJ, Fluhr JW, Feingold KR, Elias PM, Mauro TM.

J Invest Dermatol. 2007 Dec;127(12):2847-56. Epub 2007 Jun 7.


Filaggrin's fuller figure: a glimpse into the genetic architecture of atopic dermatitis.

Sandilands A, Smith FJ, Irvine AD, McLean WH.

J Invest Dermatol. 2007 Jun;127(6):1282-4. Review.


Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema.

Sandilands A, Terron-Kwiatkowski A, Hull PR, O'Regan GM, Clayton TH, Watson RM, Carrick T, Evans AT, Liao H, Zhao Y, Campbell LE, Schmuth M, Gruber R, Janecke AR, Elias PM, van Steensel MA, Nagtzaam I, van Geel M, Steijlen PM, Munro CS, Bradley DG, Palmer CN, Smith FJ, McLean WH, Irvine AD.

Nat Genet. 2007 May;39(5):650-4. Epub 2007 Apr 8.


Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis.

Weidinger S, Rodríguez E, Stahl C, Wagenpfeil S, Klopp N, Illig T, Novak N.

J Invest Dermatol. 2007 Mar;127(3):724-6. Epub 2006 Nov 9. No abstract available.

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