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Items: 1 to 20 of 41

1.

Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance.

Radhakrishnan A, Goldstein JL, McDonald JG, Brown MS.

Cell Metab. 2008 Dec;8(6):512-21. doi: 10.1016/j.cmet.2008.10.008.

2.

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes.

Infante RE, Wang ML, Radhakrishnan A, Kwon HJ, Brown MS, Goldstein JL.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15287-92. doi: 10.1073/pnas.0807328105. Epub 2008 Sep 4.

3.

Regulation of protein O-glycosylation by the endoplasmic reticulum-localized molecular chaperone Cosmc.

Ju T, Aryal RP, Stowell CJ, Cummings RD.

J Cell Biol. 2008 Aug 11;182(3):531-42. doi: 10.1083/jcb.200711151.

4.

Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking.

Zhang JR, Coleman T, Langmade SJ, Scherrer DE, Lane L, Lanier MH, Feng C, Sands MS, Schaffer JE, Semenkovich CF, Ory DS.

J Clin Invest. 2008 Jun;118(6):2281-90. doi: 10.1172/JCI32561.

5.

Cellular cholesterol trafficking and compartmentalization.

Ikonen E.

Nat Rev Mol Cell Biol. 2008 Feb;9(2):125-38. doi: 10.1038/nrm2336. Review.

PMID:
18216769
6.

Niemann-Pick type C1 I1061T mutant encodes a functional protein that is selected for endoplasmic reticulum-associated degradation due to protein misfolding.

Gelsthorpe ME, Baumann N, Millard E, Gale SE, Langmade SJ, Schaffer JE, Ory DS.

J Biol Chem. 2008 Mar 28;283(13):8229-36. doi: 10.1074/jbc.M708735200. Epub 2008 Jan 23.

7.

Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein.

Infante RE, Abi-Mosleh L, Radhakrishnan A, Dale JD, Brown MS, Goldstein JL.

J Biol Chem. 2008 Jan 11;283(2):1052-63. Epub 2007 Nov 6.

8.

Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop.

Infante RE, Radhakrishnan A, Abi-Mosleh L, Kinch LN, Wang ML, Grishin NV, Goldstein JL, Brown MS.

J Biol Chem. 2008 Jan 11;283(2):1064-75. Epub 2007 Nov 6.

9.

The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3.

Berger AC, Salazar G, Styers ML, Newell-Litwa KA, Werner E, Maue RA, Corbett AH, Faundez V.

J Cell Sci. 2007 Oct 15;120(Pt 20):3640-52. Epub 2007 Sep 25.

10.

Development of an assay for the intermembrane transfer of cholesterol by Niemann-Pick C2 protein.

Babalola JO, Wendeler M, Breiden B, Arenz C, Schwarzmann G, Locatelli-Hoops S, Sandhoff K.

Biol Chem. 2007 Jun;388(6):617-26.

PMID:
17552909
11.

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols.

Liou HL, Dixit SS, Xu S, Tint GS, Stock AM, Lobel P.

J Biol Chem. 2006 Dec 1;281(48):36710-23. Epub 2006 Oct 2.

12.

Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase.

Fernández-Hernando C, Fukata M, Bernatchez PN, Fukata Y, Lin MI, Bredt DS, Sessa WC.

J Cell Biol. 2006 Jul 31;174(3):369-77. Epub 2006 Jul 24.

13.

Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells.

Miao RQ, Gao Y, Harrison KD, Prendergast J, Acevedo LM, Yu J, Hu F, Strittmatter SM, Sessa WC.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10997-1002. Epub 2006 Jul 11.

14.

Intracellular sterol transport and distribution.

Maxfield FR, Menon AK.

Curr Opin Cell Biol. 2006 Aug;18(4):379-85. Epub 2006 Jun 27. Review.

PMID:
16806879
15.

Mechanism of cholesterol transfer from the Niemann-Pick type C2 protein to model membranes supports a role in lysosomal cholesterol transport.

Cheruku SR, Xu Z, Dutia R, Lobel P, Storch J.

J Biol Chem. 2006 Oct 20;281(42):31594-604. Epub 2006 Apr 10.

16.

Protein sensors for membrane sterols.

Goldstein JL, DeBose-Boyd RA, Brown MS.

Cell. 2006 Jan 13;124(1):35-46. Review.

17.

Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.

Pipalia NH, Huang A, Ralph H, Rujoi M, Maxfield FR.

J Lipid Res. 2006 Feb;47(2):284-301. Epub 2005 Nov 15.

18.

Niemann-Pick type C disease: importance of N-glycosylation sites for function and cellular location of the NPC2 protein.

Chikh K, Vey S, Simonot C, Vanier MT, Millat G.

Mol Genet Metab. 2004 Nov;83(3):220-30.

PMID:
15542393
19.

The NPC1 protein: structure implies function.

Scott C, Ioannou YA.

Biochim Biophys Acta. 2004 Oct 11;1685(1-3):8-13. Review.

PMID:
15465421
20.

Niemann-Pick C research from mouse to gene.

Pentchev PG.

Biochim Biophys Acta. 2004 Oct 11;1685(1-3):3-7. Review.

PMID:
15465420

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