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Cigarette sidestream smoke induces phosphorylated histone H2AX.

Toyooka T, Ibuki Y.

Mutat Res. 2009 May 31;676(1-2):34-40. doi: 10.1016/j.mrgentox.2009.03.002. Epub 2009 Mar 27.


Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.

Savic V, Yin B, Maas NL, Bredemeyer AL, Carpenter AC, Helmink BA, Yang-Iott KS, Sleckman BP, Bassing CH.

Mol Cell. 2009 May 15;34(3):298-310. doi: 10.1016/j.molcel.2009.04.012.


DNA double-strand breaks and their repair in blood lymphocytes of patients undergoing angiographic procedures.

Kuefner MA, Grudzenski S, Schwab SA, Wiederseiner M, Heckmann M, Bautz W, Lobrich M, Uder M.

Invest Radiol. 2009 Aug;44(8):440-6. doi: 10.1097/RLI.0b013e3181a654a5.


DNA damage response as a biomarker in treatment of leukemias.

Halicka HD, Ozkaynak MF, Levendoglu-Tugal O, Sandoval C, Seiter K, Kajstura M, Traganos F, Jayabose S, Darzynkiewicz Z.

Cell Cycle. 2009 Jun 1;8(11):1720-4. Epub 2009 Jun 30.


Crosstalk between histone modifications during the DNA damage response.

van Attikum H, Gasser SM.

Trends Cell Biol. 2009 May;19(5):207-17. doi: 10.1016/j.tcb.2009.03.001. Epub 2009 Apr 1. Review.


Exposure of HepG2 cells to low levels of PAH-containing extracts from contaminated soils results in unpredictable genotoxic stress responses.

Mattsson A, Lundstedt S, Stenius U.

Environ Mol Mutagen. 2009 May;50(4):337-48. doi: 10.1002/em.20486.


Microscopic imaging of DNA repair foci in irradiated normal tissues.

Bhogal N, Jalali F, Bristow RG.

Int J Radiat Biol. 2009 Sep;85(9):732-46. doi: 10.1080/09553000902785791. Review.


Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors.

Hochhauser D, Meyer T, Spanswick VJ, Wu J, Clingen PH, Loadman P, Cobb M, Gumbrell L, Begent RH, Hartley JA, Jodrell D.

Clin Cancer Res. 2009 Mar 15;15(6):2140-7. doi: 10.1158/1078-0432.CCR-08-1315. Epub 2009 Mar 10.


Genotoxicity of 3,6-dinitrobenzo[e]pyrene, a novel mutagen in ambient air and surface soil, in mammalian cells in vitro and in vivo.

Kawanishi M, Watanabe T, Hagio S, Ogo S, Shimohara C, Jouchi R, Takayama S, Hasei T, Hirayama T, Oda Y, Yagi T.

Mutagenesis. 2009 May;24(3):279-84. doi: 10.1093/mutage/gep007. Epub 2009 Mar 8.


Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.

Cook PJ, Ju BG, Telese F, Wang X, Glass CK, Rosenfeld MG.

Nature. 2009 Apr 2;458(7238):591-6. doi: 10.1038/nature07849. Epub 2009 Feb 22.


Two-tier analysis of histone H2AX phosphorylation allows the identification of Ataxia Telangiectasia heterozygotes.

Porcedda P, Turinetto V, Orlando L, Lantelme E, Brusco A, De Marchi M, Amoroso A, Ricardi U, Gregori D, Giachino C.

Radiother Oncol. 2009 Jul;92(1):133-7. doi: 10.1016/j.radonc.2008.12.010. Epub 2009 Jan 23.


Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide.

Karp JE, Flatten K, Feldman EJ, Greer JM, Loegering DA, Ricklis RM, Morris LE, Ritchie E, Smith BD, Ironside V, Talbott T, Roboz G, Le SB, Meng XW, Schneider PA, Dai NT, Adjei AA, Gore SD, Levis MJ, Wright JJ, Garrett-Mayer E, Kaufmann SH.

Blood. 2009 May 14;113(20):4841-52. doi: 10.1182/blood-2008-08-172726. Epub 2008 Dec 24.


WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.

Xiao A, Li H, Shechter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD.

Nature. 2009 Jan 1;457(7225):57-62. doi: 10.1038/nature07668. Epub 2008 Dec 17.


Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence.

Nakamura AJ, Chiang YJ, Hathcock KS, Horikawa I, Sedelnikova OA, Hodes RJ, Bonner WM.

Epigenetics Chromatin. 2008 Nov 3;1(1):6. doi: 10.1186/1756-8935-1-6.


GammaH2AX and cancer.

Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, Solier S, Pommier Y.

Nat Rev Cancer. 2008 Dec;8(12):957-67. doi: 10.1038/nrc2523. Epub 2008 Nov 13. Review.


Detection of histone H2AX phosphorylation on Ser-139 as an indicator of DNA damage (DNA double-strand breaks).

Huang X, Halicka HD, Darzynkiewicz Z.

Curr Protoc Cytom. 2004 Nov;Chapter 7:Unit 7.27. doi: 10.1002/0471142956.cy0727s30.


Tissue-specific DNA-PK-dependent H2AX phosphorylation and gamma-H2AX elimination after X-irradiation in vivo.

Koike M, Sugasawa J, Yasuda M, Koike A.

Biochem Biophys Res Commun. 2008 Nov 7;376(1):52-5. doi: 10.1016/j.bbrc.2008.08.095. Epub 2008 Aug 26.


Complementary functions of ATM and H2AX in development and suppression of genomic instability.

Zha S, Sekiguchi J, Brush JW, Bassing CH, Alt FW.

Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9302-6. doi: 10.1073/pnas.0803520105. Epub 2008 Jul 1.


Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage.

Risques RA, Lai LA, Brentnall TA, Li L, Feng Z, Gallaher J, Mandelson MT, Potter JD, Bronner MP, Rabinovitch PS.

Gastroenterology. 2008 Aug;135(2):410-8. doi: 10.1053/j.gastro.2008.04.008. Epub 2008 Apr 15.

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