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Items: 1 to 20 of 54


The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3.

Zhu J, Luo BH, Barth P, Schonbrun J, Baker D, Springer TA.

Mol Cell. 2009 Apr 24;34(2):234-49. doi: 10.1016/j.molcel.2009.02.022.


The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling.

Lau TL, Kim C, Ginsberg MH, Ulmer TS.

EMBO J. 2009 May 6;28(9):1351-61. doi: 10.1038/emboj.2009.63.


Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation.

Chigaev A, Waller A, Amit O, Halip L, Bologa CG, Sklar LA.

J Biol Chem. 2009 May 22;284(21):14337-46. doi: 10.1074/jbc.M901178200.


Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.

Zhu J, Luo BH, Xiao T, Zhang C, Nishida N, Springer TA.

Mol Cell. 2008 Dec 26;32(6):849-61. doi: 10.1016/j.molcel.2008.11.018.


Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach.

Rocco M, Rosano C, Weisel JW, Horita DA, Hantgan RR.

Structure. 2008 Jun;16(6):954-64. doi: 10.1016/j.str.2008.02.019.


Key interactions in integrin ectodomain responsible for global conformational change detected by elastic network normal-mode analysis.

Matsumoto A, Kamata T, Takagi J, Iwasaki K, Yura K.

Biophys J. 2008 Sep 15;95(6):2895-908. doi: 10.1529/biophysj.108.131045.


Integrin alpha IIb beta 3 in a membrane environment remains the same height after Mn2+ activation when observed by cryoelectron tomography.

Ye F, Liu J, Winkler H, Taylor KA.

J Mol Biol. 2008 May 16;378(5):976-86. doi: 10.1016/j.jmb.2008.03.014.


Conformational changes in human integrin alphaIIbbeta3 after platelet activation, monitored by FRET.

Coutinho A, García C, González-Rodríguez J, Lillo MP.

Biophys Chem. 2007 Oct;130(1-2):76-87.


Tests of the extension and deadbolt models of integrin activation.

Zhu J, Boylan B, Luo BH, Newman PJ, Springer TA.

J Biol Chem. 2007 Apr 20;282(16):11914-20.


Structural basis of integrin activation by talin.

Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH, Campbell ID.

Cell. 2007 Jan 12;128(1):171-82.


The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18.

Gupta V, Gylling A, Alonso JL, Sugimori T, Ianakiev P, Xiong JP, Arnaout MA.

Blood. 2007 Apr 15;109(8):3513-20.


How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation.

Puklin-Faucher E, Gao M, Schulten K, Vogel V.

J Cell Biol. 2006 Oct 23;175(2):349-60.


The specificity and function of the metal-binding sites in the integrin beta3 A-domain.

Pesho MM, Bledzka K, Michalec L, Cierniewski CS, Plow EF.

J Biol Chem. 2006 Aug 11;281(32):23034-41.


The fluorescent toolbox for assessing protein location and function.

Giepmans BN, Adams SR, Ellisman MH, Tsien RY.

Science. 2006 Apr 14;312(5771):217-24. Review.


Integrin structure, allostery, and bidirectional signaling.

Arnaout MA, Mahalingam B, Xiong JP.

Annu Rev Cell Dev Biol. 2005;21:381-410. Review.


Membrane-proximal {alpha}/{beta} stalk interactions differentially regulate integrin activation.

Kamata T, Handa M, Sato Y, Ikeda Y, Aiso S.

J Biol Chem. 2005 Jul 1;280(26):24775-83.


Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin.

Adair BD, Xiong JP, Maddock C, Goodman SL, Arnaout MA, Yeager M.

J Cell Biol. 2005 Mar 28;168(7):1109-18.


Evolution of distinct EGF domains with specific functions.

Wouters MA, Rigoutsos I, Chu CK, Feng LL, Sparrow DB, Dunwoodie SL.

Protein Sci. 2005 Apr;14(4):1091-103.


Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics.

Xiao T, Takagi J, Coller BS, Wang JH, Springer TA.

Nature. 2004 Nov 4;432(7013):59-67.


Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs.

Senes A, Engel DE, DeGrado WF.

Curr Opin Struct Biol. 2004 Aug;14(4):465-79. Review.

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