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Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.

Northcott PA, Nakahara Y, Wu X, Feuk L, Ellison DW, Croul S, Mack S, Kongkham PN, Peacock J, Dubuc A, Ra YS, Zilberberg K, McLeod J, Scherer SW, Sunil Rao J, Eberhart CG, Grajkowska W, Gillespie Y, Lach B, Grundy R, Pollack IF, Hamilton RL, Van Meter T, Carlotti CG, Boop F, Bigner D, Gilbertson RJ, Rutka JT, Taylor MD.

Nat Genet. 2009 Apr;41(4):465-72. doi: 10.1038/ng.336. Epub 2009 Mar 8.


Hedgehog: functions and mechanisms.

Varjosalo M, Taipale J.

Genes Dev. 2008 Sep 15;22(18):2454-72. doi: 10.1101/gad.1693608. Review.


Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.

Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, Bourboulas M, Schüller U, Machold R, Fishell G, Rowitch DH, Wainwright BJ, Wechsler-Reya RJ.

Cancer Cell. 2008 Aug 12;14(2):135-45. doi: 10.1016/j.ccr.2008.07.003.


Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.

Schüller U, Heine VM, Mao J, Kho AT, Dillon AK, Han YG, Huillard E, Sun T, Ligon AH, Qian Y, Ma Q, Alvarez-Buylla A, McMahon AP, Rowitch DH, Ligon KL.

Cancer Cell. 2008 Aug 12;14(2):123-34. doi: 10.1016/j.ccr.2008.07.005.


Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool.

Spassky N, Han YG, Aguilar A, Strehl L, Besse L, Laclef C, Ros MR, Garcia-Verdugo JM, Alvarez-Buylla A.

Dev Biol. 2008 May 1;317(1):246-59. doi: 10.1016/j.ydbio.2008.02.026. Epub 2008 Mar 4.


Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells.

Han YG, Spassky N, Romaguera-Ros M, Garcia-Verdugo JM, Aguilar A, Schneider-Maunoury S, Alvarez-Buylla A.

Nat Neurosci. 2008 Mar;11(3):277-84. doi: 10.1038/nn2059. Epub 2008 Feb 24.


Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms.

Corbit KC, Shyer AE, Dowdle WE, Gaulden J, Singla V, Chen MH, Chuang PT, Reiter JF.

Nat Cell Biol. 2008 Jan;10(1):70-6. Epub 2007 Dec 16. Erratum in: Nat Cell Biol. 2008 Apr;10(4):497.


The origins of medulloblastoma subtypes.

Gilbertson RJ, Ellison DW.

Annu Rev Pathol. 2008;3:341-65. Review.


Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response.

Gerdes JM, Liu Y, Zaghloul NA, Leitch CC, Lawson SS, Kato M, Beachy PA, Beales PL, DeMartino GN, Fisher S, Badano JL, Katsanis N.

Nat Genet. 2007 Nov;39(11):1350-60. Epub 2007 Sep 30.


Cilia proteins control cerebellar morphogenesis by promoting expansion of the granule progenitor pool.

Chizhikov VV, Davenport J, Zhang Q, Shih EK, Cabello OA, Fuchs JL, Yoder BK, Millen KJ.

J Neurosci. 2007 Sep 5;27(36):9780-9.


Patched1 regulates hedgehog signaling at the primary cilium.

Rohatgi R, Milenkovic L, Scott MP.

Science. 2007 Jul 20;317(5836):372-6.


Gas1 extends the range of Hedgehog action by facilitating its signaling.

Martinelli DC, Fan CM.

Genes Dev. 2007 May 15;21(10):1231-43.


Intraflagellar transport is essential for endochondral bone formation.

Haycraft CJ, Zhang Q, Song B, Jackson WS, Detloff PJ, Serra R, Yoder BK.

Development. 2007 Jan;134(2):307-16. Epub 2006 Dec 13.


Hedgehog/Ras interactions regulate early stages of pancreatic cancer.

Pasca di Magliano M, Sekine S, Ermilov A, Ferris J, Dlugosz AA, Hebrok M.

Genes Dev. 2006 Nov 15;20(22):3161-73.


A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway.

Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, McMahon AP.

Cancer Res. 2006 Oct 15;66(20):10171-8.


Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations.

Thompson MC, Fuller C, Hogg TL, Dalton J, Finkelstein D, Lau CC, Chintagumpala M, Adesina A, Ashley DM, Kellie SJ, Taylor MD, Curran T, Gajjar A, Gilbertson RJ.

J Clin Oncol. 2006 Apr 20;24(12):1924-31. Epub 2006 Mar 27.


Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.

Haycraft CJ, Banizs B, Aydin-Son Y, Zhang Q, Michaud EJ, Yoder BK.

PLoS Genet. 2005 Oct;1(4):e53. Epub 2005 Oct 28.


Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.

May SR, Ashique AM, Karlen M, Wang B, Shen Y, Zarbalis K, Reiter J, Ericson J, Peterson AS.

Dev Biol. 2005 Nov 15;287(2):378-89. Epub 2005 Oct 17.


Vertebrate Smoothened functions at the primary cilium.

Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, Reiter JF.

Nature. 2005 Oct 13;437(7061):1018-21. Epub 2005 Aug 31.


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