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Items: 1 to 20 of 50

1.

BAX activation is initiated at a novel interaction site.

Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD.

Nature. 2008 Oct 23;455(7216):1076-81. doi: 10.1038/nature07396.

2.

Do enthalpy and entropy distinguish first in class from best in class?

Freire E.

Drug Discov Today. 2008 Oct;13(19-20):869-74. doi: 10.1016/j.drudis.2008.07.005. Epub 2008 Aug 26. Review.

3.

Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1.

Day CL, Smits C, Fan FC, Lee EF, Fairlie WD, Hinds MG.

J Mol Biol. 2008 Jul 25;380(5):958-71. doi: 10.1016/j.jmb.2008.05.071. Epub 2008 Jun 4.

PMID:
18589438
4.

Bcl-2-family proteins and hematologic malignancies: history and future prospects.

Reed JC.

Blood. 2008 Apr 1;111(7):3322-30. doi: 10.1182/blood-2007-09-078162. Review. Erratum in: Blood. 2008 Jul 15;112(2):452.

5.

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

Chipuk JE, Green DR.

Trends Cell Biol. 2008 Apr;18(4):157-64. doi: 10.1016/j.tcb.2008.01.007. Epub 2008 Mar 7. Review.

6.

The BCL-2 protein family: opposing activities that mediate cell death.

Youle RJ, Strasser A.

Nat Rev Mol Cell Biol. 2008 Jan;9(1):47-59. Review.

PMID:
18097445
7.

Bcl-2-regulated apoptosis: mechanism and therapeutic potential.

Adams JM, Cory S.

Curr Opin Immunol. 2007 Oct;19(5):488-96. Epub 2007 Jul 12. Review.

8.
9.

A stapled BID BH3 helix directly binds and activates BAX.

Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, Fisher J, Smith E, Verdine GL, Korsmeyer SJ.

Mol Cell. 2006 Oct 20;24(2):199-210.

10.

NMR determination that an extended BH3 motif of pro-apoptotic BID is specifically bound to BCL-XL.

Ji H, Shekhtman A, Ghose R, McDonnell JM, Cowburn D.

Magn Reson Chem. 2006 Jul;44 Spec No:S101-7.

11.
12.

Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets.

Hinds MG, Smits C, Fredericks-Short R, Risk JM, Bailey M, Huang DC, Day CL.

Cell Death Differ. 2007 Jan;14(1):128-36. Epub 2006 Apr 28.

13.

Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles.

Denisov AY, Chen G, Sprules T, Moldoveanu T, Beauparlant P, Gehring K.

Biochemistry. 2006 Feb 21;45(7):2250-6.

PMID:
16475813
14.
15.

BCL-XL dimerization by three-dimensional domain swapping.

O'Neill JW, Manion MK, Maguire B, Hockenbery DM.

J Mol Biol. 2006 Feb 17;356(2):367-81. Epub 2005 Dec 1.

PMID:
16368107
16.

The binding of W7, an inhibitor of striated muscle contraction, to cardiac troponin C.

Hoffman RM, Li MX, Sykes BD.

Biochemistry. 2005 Dec 6;44(48):15750-9.

PMID:
16313178
17.

Comparative genomics: the evolutionary history of the Bcl-2 family.

Lanave C, Santamaria M, Saccone C.

Gene. 2004 May 26;333:71-9.

PMID:
15177682
18.

Conformation of membrane-associated proapoptotic tBid.

Gong XM, Choi J, Franzin CM, Zhai D, Reed JC, Marassi FM.

J Biol Chem. 2004 Jul 9;279(28):28954-60. Epub 2004 Apr 28.

19.

Structural biology of the Bcl-2 family of proteins.

Petros AM, Olejniczak ET, Fesik SW.

Biochim Biophys Acta. 2004 Mar 1;1644(2-3):83-94. Review.

20.

Structural studies of apoptosis and ion transport regulatory proteins in membranes.

Franzin CM, Choi J, Zhai D, Reed JC, Marassi FM.

Magn Reson Chem. 2004 Feb;42(2):172-9.

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