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The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.

Endoh-Yamagami S, Evangelista M, Wilson D, Wen X, Theunissen JW, Phamluong K, Davis M, Scales SJ, Solloway MJ, de Sauvage FJ, Peterson AS.

Curr Biol. 2009 Aug 11;19(15):1320-6. doi: 10.1016/j.cub.2009.06.046. Epub 2009 Jul 9.


The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling.

Cheung HO, Zhang X, Ribeiro A, Mo R, Makino S, Puviindran V, Law KK, Briscoe J, Hui CC.

Sci Signal. 2009 Jun 23;2(76):ra29. doi: 10.1126/scisignal.2000405.


Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling.

Lunt SC, Haynes T, Perkins BD.

Dev Dyn. 2009 Jul;238(7):1744-59. doi: 10.1002/dvdy.21999.


The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling.

Aanstad P, Santos N, Corbit KC, Scherz PJ, Trinh le A, Salvenmoser W, Huisken J, Reiter JF, Stainier DY.

Curr Biol. 2009 Jun 23;19(12):1034-9. doi: 10.1016/j.cub.2009.04.053. Epub 2009 May 21.


Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.

Wilson CW, Nguyen CT, Chen MH, Yang JH, Gacayan R, Huang J, Chen JN, Chuang PT.

Nature. 2009 May 7;459(7243):98-102. doi: 10.1038/nature07883. Epub 2009 Mar 22.


The primary cilium at the crossroads of mammalian hedgehog signaling.

Wong SY, Reiter JF.

Curr Top Dev Biol. 2008;85:225-60. doi: 10.1016/S0070-2153(08)00809-0. Review.


Hedgehog signaling in development and cancer.

Jiang J, Hui CC.

Dev Cell. 2008 Dec;15(6):801-12. doi: 10.1016/j.devcel.2008.11.010. Review.


Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.

Cortellino S, Wang C, Wang B, Bassi MR, Caretti E, Champeval D, Calmont A, Jarnik M, Burch J, Zaret KS, Larue L, Bellacosa A.

Dev Biol. 2009 Jan 1;325(1):225-37. doi: 10.1016/j.ydbio.2008.10.020. Epub 2008 Oct 29.


Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway.

Farzan SF, Ascano M Jr, Ogden SK, Sanial M, Brigui A, Plessis A, Robbins DJ.

Curr Biol. 2008 Aug 26;18(16):1215-20. doi: 10.1016/j.cub.2008.07.026. Epub 2008 Aug 7.


THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.

Tran PV, Haycraft CJ, Besschetnova TY, Turbe-Doan A, Stottmann RW, Herron BJ, Chesebro AL, Qiu H, Scherz PJ, Shah JV, Yoder BK, Beier DR.

Nat Genet. 2008 Apr;40(4):403-410. doi: 10.1038/ng.105. Epub 2008 Mar 9.


Patched1 regulates hedgehog signaling at the primary cilium.

Rohatgi R, Milenkovic L, Scott MP.

Science. 2007 Jul 20;317(5836):372-6.


Cilia and developmental signaling.

Eggenschwiler JT, Anderson KV.

Annu Rev Cell Dev Biol. 2007;23:345-73. Review.


The graded response to Sonic Hedgehog depends on cilia architecture.

Caspary T, Larkins CE, Anderson KV.

Dev Cell. 2007 May;12(5):767-78.


Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube.

Briscoe J, Novitch BG.

Philos Trans R Soc Lond B Biol Sci. 2008 Jan 12;363(1489):57-70. Review.


Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse.

Moran JL, Bolton AD, Tran PV, Brown A, Dwyer ND, Manning DK, Bjork BC, Li C, Montgomery K, Siepka SM, Vitaterna MH, Takahashi JS, Wiltshire T, Kwiatkowski DJ, Kucherlapati R, Beier DR.

Genome Res. 2006 Mar;16(3):436-40. Epub 2006 Feb 3.


Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.

Svärd J, Heby-Henricson K, Persson-Lek M, Rozell B, Lauth M, Bergström A, Ericson J, Toftgård R, Teglund S.

Dev Cell. 2006 Feb;10(2):187-97. Erratum in: Dev Cell. 2006 Mar;10(3):409. Henricson, Karin Heby [corrected to Heby-Henricson, Karin].


Divergence of hedgehog signal transduction mechanism between Drosophila and mammals.

Varjosalo M, Li SP, Taipale J.

Dev Cell. 2006 Feb;10(2):177-86.


Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.

Haycraft CJ, Banizs B, Aydin-Son Y, Zhang Q, Michaud EJ, Yoder BK.

PLoS Genet. 2005 Oct;1(4):e53. Epub 2005 Oct 28.


Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.

May SR, Ashique AM, Karlen M, Wang B, Shen Y, Zarbalis K, Reiter J, Ericson J, Peterson AS.

Dev Biol. 2005 Nov 15;287(2):378-89. Epub 2005 Oct 17.

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