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Items: 1 to 20 of 45

1.

BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.

Nakayama J, Yamamoto M, Hayashi K, Satoh H, Bundo K, Kubo M, Goitsuka R, Farrar MA, Kitamura D.

Blood. 2009 Feb 12;113(7):1483-92. doi: 10.1182/blood-2008-07-166355. Epub 2008 Dec 1.

2.

Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray.

Kawamata N, Ogawa S, Zimmermann M, Niebuhr B, Stocking C, Sanada M, Hemminki K, Yamatomo G, Nannya Y, Koehler R, Flohr T, Miller CW, Harbott J, Ludwig WD, Stanulla M, Schrappe M, Bartram CR, Koeffler HP.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11921-6. doi: 10.1073/pnas.0711039105. Epub 2008 Aug 12.

3.

Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance.

Iacobucci I, Lonetti A, Messa F, Cilloni D, Arruga F, Ottaviani E, Paolini S, Papayannidis C, Piccaluga PP, Giannoulia P, Soverini S, Amabile M, Poerio A, Saglio G, Pane F, Berton G, Baruzzi A, Vitale A, Chiaretti S, Perini G, Foà R, Baccarani M, Martinelli G.

Blood. 2008 Nov 1;112(9):3847-55. doi: 10.1182/blood-2007-09-112631. Epub 2008 Jul 23. Erratum in: Blood. 2010 Sep 23;116(12):2196.

4.

Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros.

Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H.

Nat Immunol. 2008 Aug;9(8):927-36. doi: 10.1038/ni.1626. Epub 2008 Jun 22.

5.

BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros.

Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, Ma J, White D, Hughes TP, Le Beau MM, Pui CH, Relling MV, Shurtleff SA, Downing JR.

Nature. 2008 May 1;453(7191):110-4. doi: 10.1038/nature06866. Epub 2008 Apr 13.

PMID:
18408710
8.

Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits.

Thompson EC, Cobb BS, Sabbattini P, Meixlsperger S, Parelho V, Liberg D, Taylor B, Dillon N, Georgopoulos K, Jumaa H, Smale ST, Fisher AG, Merkenschlager M.

Immunity. 2007 Mar;26(3):335-44. Erratum in: Immunity. 2007 Apr;26(4):533.

9.

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.

Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD, Girtman K, Mathew S, Ma J, Pounds SB, Su X, Pui CH, Relling MV, Evans WE, Shurtleff SA, Downing JR.

Nature. 2007 Apr 12;446(7137):758-64.

PMID:
17344859
10.

Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor.

Meixlsperger S, Köhler F, Wossning T, Reppel M, Müschen M, Jumaa H.

Immunity. 2007 Mar;26(3):323-33. Epub 2007 Mar 1.

11.
12.

The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells.

Sprangers M, Feldhahn N, Herzog S, Hansmann ML, Reppel M, Hescheler J, Jumaa H, Siebert R, Müschen M.

Oncogene. 2006 Aug 17;25(36):5056-62. Epub 2006 Mar 27.

PMID:
16568084
13.

Ikaros has a crucial role in regulation of B cell receptor signaling.

Nera KP, Alinikula J, Terho P, Narvi E, Törnquist K, Kurosaki T, Buerstedde JM, Lassila O.

Eur J Immunol. 2006 Mar;36(3):516-25.

14.

Involvement of SLP-65 and Btk in tumor suppression and malignant transformation of pre-B cells.

Hendriks RW, Kersseboom R.

Semin Immunol. 2006 Feb;18(1):67-76. Epub 2005 Nov 21. Review.

PMID:
16300960
15.

Ig gene rearrangement steps are initiated in early human precursor B cell subsets and correlate with specific transcription factor expression.

van Zelm MC, van der Burg M, de Ridder D, Barendregt BH, de Haas EF, Reinders MJ, Lankester AC, Révész T, Staal FJ, van Dongen JJ.

J Immunol. 2005 Nov 1;175(9):5912-22. Erratum in: J Immunol. 2006 Jun 15;176(12):7787.

16.

BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells.

Klein F, Feldhahn N, Herzog S, Sprangers M, Mooster JL, Jumaa H, Müschen M.

Oncogene. 2006 Feb 16;25(7):1118-24.

PMID:
16205638
17.

Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells.

Feldhahn N, Klein F, Mooster JL, Hadweh P, Sprangers M, Wartenberg M, Bekhite MM, Hofmann WK, Herzog S, Jumaa H, Rowley JD, Müschen M.

J Exp Med. 2005 Jun 6;201(11):1837-52.

18.

Ikaros induces quiescence and T-cell differentiation in a leukemia cell line.

Kathrein KL, Lorenz R, Innes AM, Griffiths E, Winandy S.

Mol Cell Biol. 2005 Mar;25(5):1645-54.

19.

A comprehensive genetic classification of adult acute lymphoblastic leukemia (ALL): analysis of the GIMEMA 0496 protocol.

Mancini M, Scappaticci D, Cimino G, Nanni M, Derme V, Elia L, Tafuri A, Vignetti M, Vitale A, Cuneo A, Castoldi G, Saglio G, Pane F, Mecucci C, Camera A, Specchia G, Tedeschi A, Di Raimondo F, Fioritoni G, Fabbiano F, Marmont F, Ferrara F, Cascavilla N, Todeschini G, Nobile F, Kropp MG, Leoni P, Tabilio A, Luppi M, Annino L, Mandelli F, Foà R.

Blood. 2005 May 1;105(9):3434-41. Epub 2005 Jan 13.

20.

Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells.

Ptasznik A, Nakata Y, Kalota A, Emerson SG, Gewirtz AM.

Nat Med. 2004 Nov;10(11):1187-9. Epub 2004 Oct 24.

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