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Forecasting the global burden of Alzheimer's disease.

Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM.

Alzheimers Dement. 2007 Jul;3(3):186-91. doi: 10.1016/j.jalz.2007.04.381.


C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity.

Fradinger EA, Monien BH, Urbanc B, Lomakin A, Tan M, Li H, Spring SM, Condron MM, Cruz L, Xie CW, Benedek GB, Bitan G.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14175-80. doi: 10.1073/pnas.0807163105. Epub 2008 Sep 8.


A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta.

Head E, Pop V, Vasilevko V, Hill M, Saing T, Sarsoza F, Nistor M, Christie LA, Milton S, Glabe C, Barrett E, Cribbs D.

J Neurosci. 2008 Apr 2;28(14):3555-66. doi: 10.1523/JNEUROSCI.0208-08.2008.


Familial Alzheimer's disease mutations alter the stability of the amyloid beta-protein monomer folding nucleus.

Grant MA, Lazo ND, Lomakin A, Condron MM, Arai H, Yamin G, Rigby AC, Teplow DB.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16522-7. Epub 2007 Oct 10.


Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, Mucke L.

J Biol Chem. 2007 Aug 17;282(33):23818-28. Epub 2007 Jun 4.


Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway.

Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL.

J Neurosci. 2007 Mar 14;27(11):2866-75.


A beta oligomers - a decade of discovery.

Walsh DM, Selkoe DJ.

J Neurochem. 2007 Jun;101(5):1172-84. Epub 2007 Feb 5. Review.


Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.

Haass C, Selkoe DJ.

Nat Rev Mol Cell Biol. 2007 Feb;8(2):101-12. Review.


beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons.

Kelly BL, Ferreira A.

J Biol Chem. 2006 Sep 22;281(38):28079-89. Epub 2006 Jul 24.


Evidence for polyproline II helical structure in short polyglutamine tracts.

Chellgren BW, Miller AF, Creamer TP.

J Mol Biol. 2006 Aug 11;361(2):362-71. Epub 2006 Jul 5.


Molecular structure of amyloid fibrils: insights from solid-state NMR.

Tycko R.

Q Rev Biophys. 2006 Feb;39(1):1-55. Epub 2006 Jun 13. Review.


Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

McLaurin J, Kierstead ME, Brown ME, Hawkes CA, Lambermon MH, Phinney AL, Darabie AA, Cousins JE, French JE, Lan MF, Chen F, Wong SS, Mount HT, Fraser PE, Westaway D, St George-Hyslop P.

Nat Med. 2006 Jul;12(7):801-8. Epub 2006 Jun 11.


Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

Deshpande A, Mina E, Glabe C, Busciglio J.

J Neurosci. 2006 May 31;26(22):6011-8.


ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures.

Chong YH, Shin YJ, Lee EO, Kayed R, Glabe CG, Tenner AJ.

J Biol Chem. 2006 Jul 21;281(29):20315-25. Epub 2006 May 18.


Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.

Huang SM, Mouri A, Kokubo H, Nakajima R, Suemoto T, Higuchi M, Staufenbiel M, Noda Y, Yamaguchi H, Nabeshima T, Saido TC, Iwata N.

J Biol Chem. 2006 Jun 30;281(26):17941-51. Epub 2006 Apr 24.


A specific amyloid-beta protein assembly in the brain impairs memory.

Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH.

Nature. 2006 Mar 16;440(7082):352-7.


Amyloid beta-protein monomer structure: a computational and experimental study.

Baumketner A, Bernstein SL, Wyttenbach T, Bitan G, Teplow DB, Bowers MT, Shea JE.

Protein Sci. 2006 Mar;15(3):420-8.


Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ.

J Physiol. 2006 Apr 15;572(Pt 2):477-92. Epub 2006 Feb 9.

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