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Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor.

Varela-Rohena A, Molloy PE, Dunn SM, Li Y, Suhoski MM, Carroll RG, Milicic A, Mahon T, Sutton DH, Laugel B, Moysey R, Cameron BJ, Vuidepot A, Purbhoo MA, Cole DK, Phillips RE, June CH, Jakobsen BK, Sewell AK, Riley JL.

Nat Med. 2008 Dec;14(12):1390-5. doi: 10.1038/nm.1779. Epub 2008 Nov 9.


A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys.

Santra S, Korber BT, Muldoon M, Barouch DH, Nabel GJ, Gao F, Hahn BH, Haynes BF, Letvin NL.

Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10489-94. doi: 10.1073/pnas.0803352105. Epub 2008 Jul 23.


Impact of MHC class I diversity on immune control of immunodeficiency virus replication.

Goulder PJ, Watkins DI.

Nat Rev Immunol. 2008 Aug;8(8):619-30. doi: 10.1038/nri2357. Review.


CD8+ T cell efficacy in vaccination and disease.

Appay V, Douek DC, Price DA.

Nat Med. 2008 Jun;14(6):623-8. doi: 10.1038/nm.f.1774. Review.


Toward an AIDS vaccine.

Walker BD, Burton DR.

Science. 2008 May 9;320(5877):760-4. doi: 10.1126/science.1152622. Review.


Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients.

Goepfert PA, Lumm W, Farmer P, Matthews P, Prendergast A, Carlson JM, Derdeyn CA, Tang J, Kaslow RA, Bansal A, Yusim K, Heckerman D, Mulenga J, Allen S, Goulder PJ, Hunter E.

J Exp Med. 2008 May 12;205(5):1009-17. doi: 10.1084/jem.20072457. Epub 2008 Apr 21.


Cross-clade detection of HIV-1-specific cytotoxic T lymphocytes does not reflect cross-clade antiviral activity.

Bennett MS, Ng HL, Ali A, Yang OO.

J Infect Dis. 2008 Feb 1;197(3):390-7. doi: 10.1086/525281.


Identification of CRF34_01B, a second circulating recombinant form unrelated to and more complex than CRF15_01B, among injecting drug users in northern Thailand.

Tovanabutra S, Kijak GH, Beyrer C, Gammon-Richardson C, Sakkhachornphop S, Vongchak T, Jittiwutikarn J, Razak MH, Sanders-Buell E, Robb ML, Suriyanon V, Birx DL, Michael NL, Celentano DD, McCutchan FE.

AIDS Res Hum Retroviruses. 2007 Jun;23(6):829-33.


The T cell repertoire in infection and vaccination: implications for control of persistent viruses.

Davenport MP, Price DA, McMichael AJ.

Curr Opin Immunol. 2007 Jun;19(3):294-300. Epub 2007 Apr 12. Review.


Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression.

Frater AJ, Brown H, Oxenius A, G√ľnthard HF, Hirschel B, Robinson N, Leslie AJ, Payne R, Crawford H, Prendergast A, Brander C, Kiepiela P, Walker BD, Goulder PJ, McLean A, Phillips RE.

J Virol. 2007 Jun;81(12):6742-51. Epub 2007 Apr 4.


In a mixed subtype epidemic, the HIV-1 Gag-specific T-cell response is biased towards the infecting subtype.

Geldmacher C, Currier JR, Gerhardt M, Haule A, Maboko L, Birx D, Gray C, Meyerhans A, Cox J, Hoelscher M.

AIDS. 2007 Jan 11;21(2):135-43.


Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants.

Fischer W, Perkins S, Theiler J, Bhattacharya T, Yusim K, Funkhouser R, Kuiken C, Haynes B, Letvin NL, Walker BD, Hahn BH, Korber BT.

Nat Med. 2007 Jan;13(1):100-6. Epub 2006 Dec 24.


CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients.

Geldmacher C, Currier JR, Herrmann E, Haule A, Kuta E, McCutchan F, Njovu L, Geis S, Hoffmann O, Maboko L, Williamson C, Birx D, Meyerhans A, Cox J, Hoelscher M.

J Virol. 2007 Mar;81(5):2440-8. Epub 2006 Dec 20.


CD8+ T-cell responses to different HIV proteins have discordant associations with viral load.

Kiepiela P, Ngumbela K, Thobakgale C, Ramduth D, Honeyborne I, Moodley E, Reddy S, de Pierres C, Mncube Z, Mkhwanazi N, Bishop K, van der Stok M, Nair K, Khan N, Crawford H, Payne R, Leslie A, Prado J, Prendergast A, Frater J, McCarthy N, Brander C, Learn GH, Nickle D, Rousseau C, Coovadia H, Mullins JI, Heckerman D, Walker BD, Goulder P.

Nat Med. 2007 Jan;13(1):46-53. Epub 2006 Dec 17.


Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.

Yu XG, Lichterfeld M, Chetty S, Williams KL, Mui SK, Miura T, Frahm N, Feeney ME, Tang Y, Pereyra F, Labute MX, Pfafferott K, Leslie A, Crawford H, Allgaier R, Hildebrand W, Kaslow R, Brander C, Allen TM, Rosenberg ES, Kiepiela P, Vajpayee M, Goepfert PA, Altfeld M, Goulder PJ, Walker BD.

J Virol. 2007 Feb;81(4):1619-31. Epub 2006 Nov 22.


Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.

Leslie A, Price DA, Mkhize P, Bishop K, Rathod A, Day C, Crawford H, Honeyborne I, Asher TE, Luzzi G, Edwards A, Rousseau CM, Mullins JI, Tudor-Williams G, Novelli V, Brander C, Douek DC, Kiepiela P, Walker BD, Goulder PJ.

J Immunol. 2006 Oct 1;177(7):4699-708. Erratum in: J Immunol. 2006 Dec 15;177(12):8878. Rosseau, Christine M [corrected to Rousseau, Christine M].


Amine reactive dyes: an effective tool to discriminate live and dead cells in polychromatic flow cytometry.

Perfetto SP, Chattopadhyay PK, Lamoreaux L, Nguyen R, Ambrozak D, Koup RA, Roederer M.

J Immunol Methods. 2006 Jun 30;313(1-2):199-208. Epub 2006 May 19.


Degeneracy and repertoire of the human HIV-1 Gag p17(77-85) CTL response.

Kan-Mitchell J, Bajcz M, Schaubert KL, Price DA, Brenchley JM, Asher TE, Douek DC, Ng HL, Yang OO, Rinaldo CR Jr, Benito JM, Bisikirska B, Hegde R, Marincola FM, Boggiano C, Wilson D, Abrams J, Blondelle SE, Wilson DB.

J Immunol. 2006 Jun 1;176(11):6690-701.


Global epidemiology of HIV.

McCutchan FE.

J Med Virol. 2006;78 Suppl 1:S7-S12.


Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses.

Price DA, Brenchley JM, Ruff LE, Betts MR, Hill BJ, Roederer M, Koup RA, Migueles SA, Gostick E, Wooldridge L, Sewell AK, Connors M, Douek DC.

J Exp Med. 2005 Nov 21;202(10):1349-61. Epub 2005 Nov 14.

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