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Items: 1 to 20 of 51

1.

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death.

Gandhi S, Wood-Kaczmar A, Yao Z, Plun-Favreau H, Deas E, Klupsch K, Downward J, Latchman DS, Tabrizi SJ, Wood NW, Duchen MR, Abramov AY.

Mol Cell. 2009 Mar 13;33(5):627-38. doi: 10.1016/j.molcel.2009.02.013.

2.

Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission.

Dagda RK, Cherra SJ 3rd, Kulich SM, Tandon A, Park D, Chu CT.

J Biol Chem. 2009 May 15;284(20):13843-55. doi: 10.1074/jbc.M808515200. Epub 2009 Mar 10.

3.

Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells.

Gegg ME, Cooper JM, Schapira AH, Taanman JW.

PLoS One. 2009;4(3):e4756. doi: 10.1371/journal.pone.0004756. Epub 2009 Mar 9.

4.

PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease.

Liu W, Vives-Bauza C, Acín-Peréz- R, Yamamoto A, Tan Y, Li Y, Magrané J, Stavarache MA, Shaffer S, Chang S, Kaplitt MG, Huang XY, Beal MF, Manfredi G, Li C.

PLoS One. 2009;4(2):e4597. doi: 10.1371/journal.pone.0004597. Epub 2009 Feb 26.

5.

Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux.

Marongiu R, Spencer B, Crews L, Adame A, Patrick C, Trejo M, Dallapiccola B, Valente EM, Masliah E.

J Neurochem. 2009 Mar;108(6):1561-74. doi: 10.1111/j.1471-4159.2009.05932.x. Epub 2009 Jan 24.

6.

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts.

Mortiboys H, Thomas KJ, Koopman WJ, Klaffke S, Abou-Sleiman P, Olpin S, Wood NW, Willems PH, Smeitink JA, Cookson MR, Bandmann O.

Ann Neurol. 2008 Nov;64(5):555-65. doi: 10.1002/ana.21492.

7.

The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process.

Park J, Lee G, Chung J.

Biochem Biophys Res Commun. 2009 Jan 16;378(3):518-23. doi: 10.1016/j.bbrc.2008.11.086. Epub 2008 Dec 3.

PMID:
19056353
8.

Mitofusin 2 tethers endoplasmic reticulum to mitochondria.

de Brito OM, Scorrano L.

Nature. 2008 Dec 4;456(7222):605-10. doi: 10.1038/nature07534. Erratum in: Nature. 2014 Sep 11;513(7517):266.

PMID:
19052620
9.

Parkin mitochondria in the autophagosome.

McBride HM.

J Cell Biol. 2008 Dec 1;183(5):757-9. doi: 10.1083/jcb.200810184. Epub 2008 Nov 24.

10.

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.

Narendra D, Tanaka A, Suen DF, Youle RJ.

J Cell Biol. 2008 Dec 1;183(5):795-803. doi: 10.1083/jcb.200809125. Epub 2008 Nov 24.

11.

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.

Cereghetti GM, Stangherlin A, Martins de Brito O, Chang CR, Blackstone C, Bernardi P, Scorrano L.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15803-8. doi: 10.1073/pnas.0808249105. Epub 2008 Oct 6.

12.

Functions and dysfunctions of mitochondrial dynamics.

Detmer SA, Chan DC.

Nat Rev Mol Cell Biol. 2007 Nov;8(11):870-9. Review.

PMID:
17928812
13.

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

Plun-Favreau H, Klupsch K, Moisoi N, Gandhi S, Kjaer S, Frith D, Harvey K, Deas E, Harvey RJ, McDonald N, Wood NW, Martins LM, Downward J.

Nat Cell Biol. 2007 Nov;9(11):1243-52. Epub 2007 Sep 30.

PMID:
17906618
15.

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1.

Pridgeon JW, Olzmann JA, Chin LS, Li L.

PLoS Biol. 2007 Jul;5(7):e172. Epub 2007 Jun 19.

16.

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice.

Kitada T, Pisani A, Porter DR, Yamaguchi H, Tscherter A, Martella G, Bonsi P, Zhang C, Pothos EN, Shen J.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11441-6. Epub 2007 Jun 11.

17.
18.

Mdm38 protein depletion causes loss of mitochondrial K+/H+ exchange activity, osmotic swelling and mitophagy.

Nowikovsky K, Reipert S, Devenish RJ, Schweyen RJ.

Cell Death Differ. 2007 Sep;14(9):1647-56. Epub 2007 Jun 1.

19.

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

Greggio E, Lewis PA, van der Brug MP, Ahmad R, Kaganovich A, Ding J, Beilina A, Baker AK, Cookson MR.

J Neurochem. 2007 Jul;102(1):93-102. Epub 2007 Mar 29.

20.

The SUMO protease SENP5 is required to maintain mitochondrial morphology and function.

Zunino R, Schauss A, Rippstein P, Andrade-Navarro M, McBride HM.

J Cell Sci. 2007 Apr 1;120(Pt 7):1178-88. Epub 2007 Mar 6.

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