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Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

Reinhardt HC, Yaffe MB.

Curr Opin Cell Biol. 2009 Apr;21(2):245-55. doi: 10.1016/ Epub 2009 Feb 21. Review.


Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.

Gong Z, Cho YW, Kim JE, Ge K, Chen J.

J Biol Chem. 2009 Mar 13;284(11):7284-93. doi: 10.1074/jbc.M809158200. Epub 2009 Jan 5.


Chk2 oligomerization studied by phosphopeptide ligation: implications for regulation and phosphodependent interactions.

Li J, Taylor IA, Lloyd J, Clapperton JA, Howell S, MacMillan D, Smerdon SJ.

J Biol Chem. 2008 Dec 19;283(51):36019-30. doi: 10.1074/jbc.M804075200. Epub 2008 Oct 23.


14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers.

Rajagopalan S, Jaulent AM, Wells M, Veprintsev DB, Fersht AR.

Nucleic Acids Res. 2008 Oct;36(18):5983-91. doi: 10.1093/nar/gkn598. Epub 2008 Sep 23.


Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair.

Wood JL, Liang Y, Li K, Chen J.

J Biol Chem. 2008 Oct 24;283(43):29586-92. doi: 10.1074/jbc.M804080200. Epub 2008 Aug 21.


MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks.

Wu L, Luo K, Lou Z, Chen J.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11200-5. doi: 10.1073/pnas.0802885105. Epub 2008 Aug 4.


MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.

Yang SZ, Lin FT, Lin WC.

EMBO Rep. 2008 Sep;9(9):907-15. doi: 10.1038/embor.2008.128. Epub 2008 Jul 25.


Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage.

Chapman JR, Jackson SP.

EMBO Rep. 2008 Aug;9(8):795-801. doi: 10.1038/embor.2008.103. Epub 2008 Jun 27.


Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites.

Xu C, Wu L, Cui G, Botuyan MV, Chen J, Mer G.

J Mol Biol. 2008 Aug 29;381(2):361-72. doi: 10.1016/j.jmb.2008.05.087. Epub 2008 Jun 14.


Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.

Spycher C, Miller ES, Townsend K, Pavic L, Morrice NA, Janscak P, Stewart GS, Stucki M.

J Cell Biol. 2008 Apr 21;181(2):227-40. doi: 10.1083/jcb.200709008. Epub 2008 Apr 14.


Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin.

Melander F, Bekker-Jensen S, Falck J, Bartek J, Mailand N, Lukas J.

J Cell Biol. 2008 Apr 21;181(2):213-26. doi: 10.1083/jcb.200708210. Epub 2008 Apr 14.


Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.

Wang B, Elledge SJ.

Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20759-63. Epub 2007 Dec 5.


Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.

Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D.

Science. 2007 Dec 7;318(5856):1637-40. Epub 2007 Nov 15.


RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J.

Cell. 2007 Nov 30;131(5):901-14. Epub 2007 Nov 20.


RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J.

Cell. 2007 Nov 30;131(5):887-900. Epub 2007 Nov 20.


MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.

Wood JL, Singh N, Mer G, Chen J.

J Biol Chem. 2007 Nov 30;282(48):35416-23. Epub 2007 Oct 9.


DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.

Sun Y, Xu Y, Roy K, Price BD.

Mol Cell Biol. 2007 Dec;27(24):8502-9. Epub 2007 Oct 8.


Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage.

Munoz IM, Jowsey PA, Toth R, Rouse J.

Nucleic Acids Res. 2007;35(16):5312-22. Epub 2007 Aug 8.


CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response.

Kim H, Huang J, Chen J.

Nat Struct Mol Biol. 2007 Aug;14(8):710-5. Epub 2007 Jul 22.


Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization.

Jeffers LJ, Coull BJ, Stack SJ, Morrison CG.

Oncogene. 2008 Jan 3;27(1):139-44. Epub 2007 Jun 25.


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