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Items: 17

1.

Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis.

Barker RH Jr, Liu H, Hirth B, Celatka CA, Fitzpatrick R, Xiang Y, Willert EK, Phillips MA, Kaiser M, Bacchi CJ, Rodriguez A, Yarlett N, Klinger JD, Sybertz E.

Antimicrob Agents Chemother. 2009 May;53(5):2052-8. doi: 10.1128/AAC.01674-08. Epub 2009 Mar 16.

PMID:
19289530
2.

New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.

McCloskey DE, Bale S, Secrist JA 3rd, Tiwari A, Moss TH 3rd, Valiyaveettil J, Brooks WH, Guida WC, Pegg AE, Ealick SE.

J Med Chem. 2009 Mar 12;52(5):1388-407. doi: 10.1021/jm801126a.

PMID:
19209891
3.

Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes.

Willert EK, Phillips MA.

PLoS Pathog. 2008 Oct;4(10):e1000183. doi: 10.1371/journal.ppat.1000183. Epub 2008 Oct 24.

PMID:
18949025
4.

The trypanothione system.

Krauth-Siegel LR, Comini MA, Schlecker T.

Subcell Biochem. 2007;44:231-51. Review.

PMID:
18084897
5.

Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo.

Priotto G, Kasparian S, Ngouama D, Ghorashian S, Arnold U, Ghabri S, Karunakara U.

Clin Infect Dis. 2007 Dec 1;45(11):1435-42. Epub 2007 Oct 22.

PMID:
17990225
6.

Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog.

Willert EK, Fitzpatrick R, Phillips MA.

Proc Natl Acad Sci U S A. 2007 May 15;104(20):8275-80. Epub 2007 May 7.

PMID:
17485680
7.

Drugs and drug resistance in African trypanosomiasis.

Delespaux V, de Koning HP.

Drug Resist Updat. 2007 Feb-Apr;10(1-2):30-50. Epub 2007 Apr 3. Review.

PMID:
17409013
8.

Antitrypanosomal activity of purine nucleosides can be enhanced by their conversion to O-acetylated derivatives.

Sufrin JR, Rattendi D, Spiess AJ, Lane S, Marasco CJ Jr, Bacchi CJ.

Antimicrob Agents Chemother. 1996 Nov;40(11):2567-72.

PMID:
8913466
9.

In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors.

Bacchi CJ, Brun R, Croft SL, Alicea K, B├╝hler Y.

Antimicrob Agents Chemother. 1996 Jun;40(6):1448-53.

PMID:
8726018
10.

Polyamine metabolism: a potential therapeutic target in trypanosomes.

Bacchi CJ, Nathan HC, Hutner SH, McCann PP, Sjoerdsma A.

Science. 1980 Oct 17;210(4467):332-4.

PMID:
6775372
11.

New drug combination for experimental late-stage African trypanosomiasis: DL-alpha-difluoromethylornithine (DFMO) with suramin.

Clarkson AB Jr, Bienen EJ, Bacchi CJ, McCann PP, Nathan HC, Hutner SH, Sjoerdsma A.

Am J Trop Med Hyg. 1984 Nov;33(6):1073-7.

PMID:
6439061
12.

In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei.

Fairlamb AH, Henderson GB, Bacchi CJ, Cerami A.

Mol Biochem Parasitol. 1987 Jun;24(2):185-91.

PMID:
3114634
13.

Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense.

Bacchi CJ, Nathan HC, Livingston T, Valladares G, Saric M, Sayer PD, Njogu AR, Clarkson AB Jr.

Antimicrob Agents Chemother. 1990 Jun;34(6):1183-8.

PMID:
2118325
14.

Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase.

Bitonti AJ, Byers TL, Bush TL, Casara PJ, Bacchi CJ, Clarkson AB Jr, McCann PP, Sjoerdsma A.

Antimicrob Agents Chemother. 1990 Aug;34(8):1485-90.

PMID:
1977366
15.

Antitrypanosomal effects of polyamine biosynthesis inhibitors correlate with increases in Trypanosoma brucei brucei S-adenosyl-L-methionine.

Byers TL, Bush TL, McCann PP, Bitonti AJ.

Biochem J. 1991 Mar 1;274 ( Pt 2):527-33.

PMID:
1672500
16.

Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor.

Bacchi CJ, Nathan HC, Yarlett N, Goldberg B, McCann PP, Bitonti AJ, Sjoerdsma A.

Antimicrob Agents Chemother. 1992 Dec;36(12):2736-40.

PMID:
1482141
17.

The relationship between duration of infection with Trypanosoma brucei in mice and the efficacy of chemotherapy.

Jennings FW, Whitelaw DD, Urquhart GM.

Parasitology. 1977 Oct;75(2):143-53. No abstract available.

PMID:
583635

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