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Role of fatty acids in the development of insulin resistance and type 2 diabetes mellitus.

Wolf G.

Nutr Rev. 2008 Oct;66(10):597-600. doi: 10.1111/j.1753-4887.2008.00110.x. Review.


Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome.

Adiels M, Olofsson SO, Taskinen MR, Borén J.

Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1225-36. doi: 10.1161/ATVBAHA.107.160192. Review.


Fatty liver, insulin resistance, and dyslipidemia.

Adiels M, Taskinen MR, Borén J.

Curr Diab Rep. 2008 Feb;8(1):60-4. Review.


Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.

Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Alemán JO, Suzuki R, Scapa EF, Agarwal C, Carey MC, Stephanopoulos G, Cohen DE, King GL, Ginsberg HN, Kahn CR.

Cell Metab. 2008 Feb;7(2):125-34. doi: 10.1016/j.cmet.2007.11.013.


Cell signaling and nuclear receptors: new opportunities for molecular pharmaceuticals in liver disease.

Staudinger JL, Lichti K.

Mol Pharm. 2008 Jan-Feb;5(1):17-34. Epub 2007 Dec 27. Review.


Pathology of nonalcoholic fatty liver disease.

Yeh MM, Brunt EM.

Am J Clin Pathol. 2007 Nov;128(5):837-47. Review.


Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance.

Zhang D, Liu ZX, Choi CS, Tian L, Kibbey R, Dong J, Cline GW, Wood PA, Shulman GI.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17075-80. Epub 2007 Oct 16.


Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk.

Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM.

J Clin Invest. 2007 Nov;117(11):3463-74.


Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss.

Croce MA, Eagon JC, LaRiviere LL, Korenblat KM, Klein S, Finck BN.

Diabetes. 2007 Sep;56(9):2395-9. Epub 2007 Jun 11.


Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.

Li X, Monks B, Ge Q, Birnbaum MJ.

Nature. 2007 Jun 21;447(7147):1012-6. Epub 2007 Jun 6.


Disordered lipid metabolism and the pathogenesis of insulin resistance.

Savage DB, Petersen KF, Shulman GI.

Physiol Rev. 2007 Apr;87(2):507-20. Review.


Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.

Handschin C, Spiegelman BM.

Endocr Rev. 2006 Dec;27(7):728-35. Epub 2006 Oct 3. Review.


Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice.

Burgess SC, Leone TC, Wende AR, Croce MA, Chen Z, Sherry AD, Malloy CR, Finck BN.

J Biol Chem. 2006 Jul 14;281(28):19000-8. Epub 2006 May 2.


Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism.

Rhee J, Ge H, Yang W, Fan M, Handschin C, Cooper M, Lin J, Li C, Spiegelman BM.

J Biol Chem. 2006 May 26;281(21):14683-90. Epub 2006 Mar 29.


Etiology of insulin resistance.

Petersen KF, Shulman GI.

Am J Med. 2006 May;119(5 Suppl 1):S10-6. Review.


PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.

Finck BN, Kelly DP.

J Clin Invest. 2006 Mar;116(3):615-22. Review.


Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha.

Handschin C, Lin J, Rhee J, Peyer AK, Chin S, Wu PH, Meyer UA, Spiegelman BM.

Cell. 2005 Aug 26;122(4):505-15.


Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice.

Neschen S, Morino K, Hammond LE, Zhang D, Liu ZX, Romanelli AJ, Cline GW, Pongratz RL, Zhang XM, Choi CS, Coleman RA, Shulman GI.

Cell Metab. 2005 Jul;2(1):55-65.


Metabolic control through the PGC-1 family of transcription coactivators.

Lin J, Handschin C, Spiegelman BM.

Cell Metab. 2005 Jun;1(6):361-70. Review.

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