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Items: 1 to 20 of 45

1.

Identifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators.

Reynolds KA, Katritch V, Abagyan R.

J Comput Aided Mol Des. 2009 May;23(5):273-88. doi: 10.1007/s10822-008-9257-9. Epub 2009 Jan 16.

2.

Selective structure-based virtual screening for full and partial agonists of the beta2 adrenergic receptor.

de Graaf C, Rognan D.

J Med Chem. 2008 Aug 28;51(16):4978-85. doi: 10.1021/jm800710x. Epub 2008 Aug 5. Erratum in: J Med Chem. 2008 Oct 23;51(20). doi: 10.1021/jm8010838.

PMID:
18680279
3.

Structure of a beta1-adrenergic G-protein-coupled receptor.

Warne T, Serrano-Vega MJ, Baker JG, Moukhametzianov R, Edwards PC, Henderson R, Leslie AG, Tate CG, Schertler GF.

Nature. 2008 Jul 24;454(7203):486-91. doi: 10.1038/nature07101. Epub 2008 Jun 25.

4.

A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.

Hanson MA, Cherezov V, Griffith MT, Roth CB, Jaakola VP, Chien EY, Velasquez J, Kuhn P, Stevens RC.

Structure. 2008 Jun;16(6):897-905. doi: 10.1016/j.str.2008.05.001.

5.

Structural diversity of G protein-coupled receptors and significance for drug discovery.

Lagerström MC, Schiöth HB.

Nat Rev Drug Discov. 2008 Apr;7(4):339-57. doi: 10.1038/nrd2518. Review. Erratum in: Nat Rev Drug Discov. 2008 Jun;7(6):542.

PMID:
18382464
6.

New G-protein-coupled receptor crystal structures: insights and limitations.

Kobilka B, Schertler GF.

Trends Pharmacol Sci. 2008 Feb;29(2):79-83. doi: 10.1016/j.tips.2007.11.009. Epub 2008 Jan 14. Review.

PMID:
18194818
7.

Conformational changes in G-protein-coupled receptors-the quest for functionally selective conformations is open.

Hoffmann C, Zürn A, Bünemann M, Lohse MJ.

Br J Pharmacol. 2008 Mar;153 Suppl 1:S358-66. Epub 2007 Dec 3. Review.

8.

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC.

Science. 2007 Nov 23;318(5854):1258-65. Epub 2007 Oct 25.

9.

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.

Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK.

Science. 2007 Nov 23;318(5854):1266-73. Epub 2007 Oct 25.

10.

Conformational complexity of G-protein-coupled receptors.

Kobilka BK, Deupi X.

Trends Pharmacol Sci. 2007 Aug;28(8):397-406. Epub 2007 Jul 13. Review.

PMID:
17629961
11.

3-Dimensional structures of G protein-coupled receptors and binding sites of agonists and antagonists.

Goddard WA 3rd, Abrol R.

J Nutr. 2007 Jun;137(6 Suppl 1):1528S-1538S; discussion 1548S. Review.

12.

Role of group-conserved residues in the helical core of beta2-adrenergic receptor.

Chelikani P, Hornak V, Eilers M, Reeves PJ, Smith SO, RajBhandary UL, Khorana HG.

Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7027-32. Epub 2007 Apr 16.

13.

G protein coupled receptor structure and activation.

Kobilka BK.

Biochim Biophys Acta. 2007 Apr;1768(4):794-807. Epub 2006 Nov 15. Review.

14.

GPCR agonists and antagonists in the clinic.

Tyndall JD, Sandilya R.

Med Chem. 2005 Jul;1(4):405-21. Review.

PMID:
16789897
15.

Molecular evolution of adrenoceptors and dopamine receptors: implications for the binding of catecholamines.

Xhaard H, Rantanen VV, Nyrönen T, Johnson MS.

J Med Chem. 2006 Mar 9;49(5):1706-19.

PMID:
16509586
16.

Molecular mechanism of 7TM receptor activation--a global toggle switch model.

Schwartz TW, Frimurer TM, Holst B, Rosenkilde MM, Elling CE.

Annu Rev Pharmacol Toxicol. 2006;46:481-519. Review.

PMID:
16402913
17.

Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists.

Swaminath G, Deupi X, Lee TW, Zhu W, Thian FS, Kobilka TS, Kobilka B.

J Biol Chem. 2005 Jun 10;280(23):22165-71. Epub 2005 Apr 7.

19.

"Induced-fit" mechanism for catecholamine binding to the beta2-adrenergic receptor.

Del Carmine R, Molinari P, Sbraccia M, Ambrosio C, Costa T.

Mol Pharmacol. 2004 Aug;66(2):356-63.

20.

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