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Items: 1 to 20 of 64

1.

Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.

Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim SH, Zheng H, Sisodia SS, Li YM.

J Biol Chem. 2009 Jan 30;284(5):2967-77. doi: 10.1074/jbc.M807269200. Epub 2008 Nov 25.

2.

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses.

Bertram L, Tanzi RE.

Nat Rev Neurosci. 2008 Oct;9(10):768-78. doi: 10.1038/nrn2494. Review.

PMID:
18802446
3.

The influence of physiological and surgical menopause on coronary heart disease risk markers.

Verhoeven MO, van der Mooren MJ, Teerlink T, Verheijen RH, Scheffer PG, Kenemans P.

Menopause. 2009 Jan-Feb;16(1):37-49. doi: 10.1097/gme.0b013e31817c42d6.

PMID:
18791484
4.

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity.

Jan A, Gokce O, Luthi-Carter R, Lashuel HA.

J Biol Chem. 2008 Oct 17;283(42):28176-89. doi: 10.1074/jbc.M803159200. Epub 2008 Aug 11.

5.

Dementia of the Alzheimer type.

Jalbert JJ, Daiello LA, Lapane KL.

Epidemiol Rev. 2008;30:15-34. doi: 10.1093/epirev/mxn008. Epub 2008 Jul 16. Review.

PMID:
18635578
6.

Direct and potent regulation of gamma-secretase by its lipid microenvironment.

Osenkowski P, Ye W, Wang R, Wolfe MS, Selkoe DJ.

J Biol Chem. 2008 Aug 15;283(33):22529-40. doi: 10.1074/jbc.M801925200. Epub 2008 Jun 6.

7.

Influence of aging and menopause on lipids and lipoproteins in women.

Kolovou GD, Bilianou HG.

Angiology. 2008 Apr-May;59(2 Suppl):54S-7S. doi: 10.1177/0003319708319645. Epub 2008 May 29. Review.

PMID:
18515273
8.

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.

Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, Saido TC, Klein WL, Duff KE, Aisen PS, Matsuoka Y.

Brain Res. 2008 Jun 24;1216:92-103. doi: 10.1016/j.brainres.2008.03.079. Epub 2008 Apr 10.

PMID:
18486110
9.

A closer look at alpha-secretase.

Postina R.

Curr Alzheimer Res. 2008 Apr;5(2):179-86. Review.

PMID:
18393803
10.

Presenilins are required for maintenance of neural stem cells in the developing brain.

Kim WY, Shen J.

Mol Neurodegener. 2008 Jan 8;3:2. doi: 10.1186/1750-1326-3-2.

11.

Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus.

Breunig JJ, Silbereis J, Vaccarino FM, Sestan N, Rakic P.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20558-63. Epub 2007 Dec 11.

12.

{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE.

Yin YI, Bassit B, Zhu L, Yang X, Wang C, Li YM.

J Biol Chem. 2007 Aug 10;282(32):23639-44. Epub 2007 Jun 7.

13.

Estrogen, beta-amyloid metabolism/trafficking, and Alzheimer's disease.

Xu H, Wang R, Zhang YW, Zhang X.

Ann N Y Acad Sci. 2006 Nov;1089:324-42.

PMID:
17261779
14.

Abeta40 inhibits amyloid deposition in vivo.

Kim J, Onstead L, Randle S, Price R, Smithson L, Zwizinski C, Dickson DW, Golde T, McGowan E.

J Neurosci. 2007 Jan 17;27(3):627-33.

15.

Gender dependent APP processing in a transgenic mouse model of Alzheimer's disease.

Schäfer S, Wirths O, Multhaup G, Bayer TA.

J Neural Transm (Vienna). 2007 Mar;114(3):387-94. Epub 2006 Oct 31.

PMID:
17075721
16.

Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.

Deng Y, Tarassishin L, Kallhoff V, Peethumnongsin E, Wu L, Li YM, Zheng H.

J Neurosci. 2006 Apr 5;26(14):3845-54.

17.

Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model.

Yue X, Lu M, Lancaster T, Cao P, Honda S, Staufenbiel M, Harada N, Zhong Z, Shen Y, Li R.

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19198-203. Epub 2005 Dec 19.

18.

Down-regulation of endogenous amyloid precursor protein processing due to cellular aging.

Kern A, Roempp B, Prager K, Walter J, Behl C.

J Biol Chem. 2006 Feb 3;281(5):2405-13. Epub 2005 Nov 22. Erratum in: J Biol Chem. 2006 May 5;281(18):13000.

19.
20.

Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism.

Lukiw WJ, Pappolla M, Pelaez RP, Bazan NG.

Cell Mol Neurobiol. 2005 Jun;25(3-4):475-83. Review.

PMID:
16075376

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