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Items: 1 to 20 of 52


Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine.

Fre S, Pallavi SK, Huyghe M, Laé M, Janssen KP, Robine S, Artavanis-Tsakonas S, Louvard D.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6309-14. doi: 10.1073/pnas.0900427106. Epub 2009 Feb 27.


Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.

Robert-Moreno A, Guiu J, Ruiz-Herguido C, López ME, Inglés-Esteve J, Riera L, Tipping A, Enver T, Dzierzak E, Gridley T, Espinosa L, Bigas A.

EMBO J. 2008 Jul 9;27(13):1886-95. doi: 10.1038/emboj.2008.113. Epub 2008 Jun 5.


Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras.

Laurent E, McCoy JW 3rd, Macina RA, Liu W, Cheng G, Robine S, Papkoff J, Lambeth JD.

Int J Cancer. 2008 Jul 1;123(1):100-7. doi: 10.1002/ijc.23423.


Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.

Riccio O, van Gijn ME, Bezdek AC, Pellegrinet L, van Es JH, Zimber-Strobl U, Strobl LJ, Honjo T, Clevers H, Radtke F.

EMBO Rep. 2008 Apr;9(4):377-83. doi: 10.1038/embor.2008.7. Epub 2008 Feb 15.


Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis.

Nandan MO, McConnell BB, Ghaleb AM, Bialkowska AB, Sheng H, Shao J, Babbin BA, Robine S, Yang VW.

Gastroenterology. 2008 Jan;134(1):120-30. Epub 2007 Oct 17.


Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.

Leong KG, Niessen K, Kulic I, Raouf A, Eaves C, Pollet I, Karsan A.

J Exp Med. 2007 Nov 26;204(12):2935-48. Epub 2007 Nov 5.


Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium.

Bastide P, Darido C, Pannequin J, Kist R, Robine S, Marty-Double C, Bibeau F, Scherer G, Joubert D, Hollande F, Blache P, Jay P.

J Cell Biol. 2007 Aug 13;178(4):635-48.


SOX9 is required for the differentiation of paneth cells in the intestinal epithelium.

Mori-Akiyama Y, van den Born M, van Es JH, Hamilton SR, Adams HP, Zhang J, Clevers H, de Crombrugghe B.

Gastroenterology. 2007 Aug;133(2):539-46. Epub 2007 May 21.


Phenotypic characterization of human colorectal cancer stem cells.

Dalerba P, Dylla SJ, Park IK, Liu R, Wang X, Cho RW, Hoey T, Gurney A, Huang EH, Simeone DM, Shelton AA, Parmiani G, Castelli C, Clarke MF.

Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10158-63. Epub 2007 Jun 4.


Myc deletion rescues Apc deficiency in the small intestine.

Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos D, Clevers H, Clarke AR.

Nature. 2007 Apr 5;446(7136):676-9. Epub 2007 Mar 21.


Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer.

Fernández-Majada V, Aguilera C, Villanueva A, Vilardell F, Robert-Moreno A, Aytés A, Real FX, Capella G, Mayo MW, Espinosa L, Bigas A.

Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):276-81. Epub 2006 Dec 26. Erratum in: Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5650.


NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.

Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, Califano A, Ferrando AA.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18261-6. Epub 2006 Nov 17. Erratum in: Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4240.


Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis.

Estrach S, Ambler CA, Lo Celso C, Hozumi K, Watt FM.

Development. 2006 Nov;133(22):4427-38. Epub 2006 Oct 11.


A garden of Notch-ly delights.

Weinmaster G, Kopan R.

Development. 2006 Sep;133(17):3277-82. Erratum in: Development. 2006 Dec;133(23):4793.


Notch synergizes with axin to regulate the activity of armadillo in Drosophila.

Hayward P, Balayo T, Martinez Arias A.

Dev Dyn. 2006 Oct;235(10):2656-66.


Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors.

Pardal R, Molofsky AV, He S, Morrison SJ.

Cold Spring Harb Symp Quant Biol. 2005;70:177-85. Review.


c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.

Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, Pear WS, Aster JC.

Genes Dev. 2006 Aug 1;20(15):2096-109. Epub 2006 Jul 17. Erratum in: Genes Dev. 2007 Mar 1;21(5):625.


Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression.

Balint K, Xiao M, Pinnix CC, Soma A, Veres I, Juhasz I, Brown EJ, Capobianco AJ, Herlyn M, Liu ZJ.

J Clin Invest. 2005 Nov;115(11):3166-76. Epub 2005 Oct 20.


Expression of NOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease.

Szanto I, Rubbia-Brandt L, Kiss P, Steger K, Banfi B, Kovari E, Herrmann F, Hadengue A, Krause KH.

J Pathol. 2005 Oct;207(2):164-76.


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