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Items: 1 to 20 of 42


Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality.

Ke Y, Zhang EE, Hagihara K, Wu D, Pang Y, Klein R, Curran T, Ranscht B, Feng GS.

Mol Cell Biol. 2007 Oct;27(19):6706-17. Epub 2007 Jul 23.


Role of Gab2 in mammary tumorigenesis and metastasis.

Ke Y, Wu D, Princen F, Nguyen T, Pang Y, Lesperance J, Muller WJ, Oshima RG, Feng GS.

Oncogene. 2007 Jul 26;26(34):4951-60. Epub 2007 Feb 19.


Self-renewal of embryonic stem cells by a small molecule.

Chen S, Do JT, Zhang Q, Yao S, Yan F, Peters EC, Schöler HR, Schultz PG, Ding S.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17266-71. Epub 2006 Nov 6.


PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.

Chan RJ, Feng GS.

Blood. 2007 Feb 1;109(3):862-7. Epub 2006 Oct 19.


Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation.

Ke Y, Lesperance J, Zhang EE, Bard-Chapeau EA, Oshima RG, Muller WJ, Feng GS.

J Biol Chem. 2006 Nov 10;281(45):34374-80. Epub 2006 Sep 7.


Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection.

Bard-Chapeau EA, Yuan J, Droin N, Long S, Zhang EE, Nguyen TV, Feng GS.

Mol Cell Biol. 2006 Jun;26(12):4664-74.


Control of developmental regulators by Polycomb in human embryonic stem cells.

Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, Yuan B, Bell GW, Herbolsheimer E, Hannett NM, Sun K, Odom DT, Otte AP, Volkert TL, Bartel DP, Melton DA, Gifford DK, Jaenisch R, Young RA.

Cell. 2006 Apr 21;125(2):301-13.


The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells.

Loh YH, Wu Q, Chew JL, Vega VB, Zhang W, Chen X, Bourque G, George J, Leong B, Liu J, Wong KY, Sung KW, Lee CW, Zhao XD, Chiu KP, Lipovich L, Kuznetsov VA, Robson P, Stanton LW, Wei CL, Ruan Y, Lim B, Ng HH.

Nat Genet. 2006 Apr;38(4):431-40. Epub 2006 Mar 5.


An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival.

Yang W, Klaman LD, Chen B, Araki T, Harada H, Thomas SM, George EL, Neel BG.

Dev Cell. 2006 Mar;10(3):317-27.


Core transcriptional regulatory circuitry in human embryonic stem cells.

Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA.

Cell. 2005 Sep 23;122(6):947-56.


The disparate role of BMP in stem cell biology.

Varga AC, Wrana JL.

Oncogene. 2005 Aug 29;24(37):5713-21. Review.


Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells.

Dravid G, Ye Z, Hammond H, Chen G, Pyle A, Donovan P, Yu X, Cheng L.

Stem Cells. 2005 Nov-Dec;23(10):1489-501. Epub 2005 Jul 7.


Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells.

Dvorak P, Dvorakova D, Koskova S, Vodinska M, Najvirtova M, Krekac D, Hampl A.

Stem Cells. 2005 Sep;23(8):1200-11. Epub 2005 Jun 13.


A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis.

He F, Ge W, Martinowich K, Becker-Catania S, Coskun V, Zhu W, Wu H, Castro D, Guillemot F, Fan G, de Vellis J, Sun YE.

Nat Neurosci. 2005 May;8(5):616-25. Epub 2005 Apr 24.


Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells.

Xu RH, Peck RM, Li DS, Feng X, Ludwig T, Thomson JA.

Nat Methods. 2005 Mar;2(3):185-90. Epub 2005 Feb 17.


Transcriptome profiling of human and murine ESCs identifies divergent paths required to maintain the stem cell state.

Wei CL, Miura T, Robson P, Lim SK, Xu XQ, Lee MY, Gupta S, Stanton L, Luo Y, Schmitt J, Thies S, Wang W, Khrebtukova I, Zhou D, Liu ET, Ruan YJ, Rao M, Lim B.

Stem Cells. 2005 Feb;23(2):166-85.


Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds.

Tautz L, Bruckner S, Sareth S, Alonso A, Bogetz J, Bottini N, Pellecchia M, Mustelin T.

J Biol Chem. 2005 Mar 11;280(10):9400-8. Epub 2004 Dec 22.


Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism.

Zhang EE, Chapeau E, Hagihara K, Feng GS.

Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):16064-9. Epub 2004 Nov 1.


STAT3 is dispensable for maintenance of self-renewal in nonhuman primate embryonic stem cells.

Sumi T, Fujimoto Y, Nakatsuji N, Suemori H.

Stem Cells. 2004;22(5):861-72.

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