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Items: 1 to 20 of 43

1.

Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs.

Rogers CS, Stoltz DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Hanfland RA, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray PB Jr, Zabner J, Prather RS, Welsh MJ.

Science. 2008 Sep 26;321(5897):1837-41. doi: 10.1126/science.1163600.

2.

Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice.

MacDonald KD, McKenzie KR, Henderson MJ, Hawkins CE, Vij N, Zeitlin PL.

Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L933-40. doi: 10.1152/ajplung.90221.2008. Epub 2008 Sep 19.

3.

A synthetic prostone activates apical chloride channels in A6 epithelial cells.

Bao HF, Liu L, Self J, Duke BJ, Ueno R, Eaton DC.

Am J Physiol Gastrointest Liver Physiol. 2008 Aug;295(2):G234-51. doi: 10.1152/ajpgi.00366.2007. Epub 2008 May 29.

4.

The porcine lung as a potential model for cystic fibrosis.

Rogers CS, Abraham WM, Brogden KA, Engelhardt JF, Fisher JT, McCray PB Jr, McLennan G, Meyerholz DK, Namati E, Ostedgaard LS, Prather RS, Sabater JR, Stoltz DA, Zabner J, Welsh MJ.

Am J Physiol Lung Cell Mol Physiol. 2008 Aug;295(2):L240-63. doi: 10.1152/ajplung.90203.2008. Epub 2008 May 16. Review.

5.

Effects of lubiprostone on human uterine smooth muscle cells.

Cuppoletti J, Malinowska DH, Chakrabarti J, Ueno R.

Prostaglandins Other Lipid Mediat. 2008 Jun;86(1-4):56-60. doi: 10.1016/j.prostaglandins.2008.03.001. Epub 2008 Mar 22.

PMID:
18440264
6.

Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon.

Bassil AK, Borman RA, Jarvie EM, McArthur-Wilson RJ, Thangiah R, Sung EZ, Lee K, Sanger GJ.

Br J Pharmacol. 2008 May;154(1):126-35. doi: 10.1038/bjp.2008.84. Epub 2008 Mar 10.

7.

Sodium channels and cystic fibrosis.

Donaldson SH, Boucher RC.

Chest. 2007 Nov;132(5):1631-6. Review.

PMID:
17998363
8.

Lubiprostone: a chloride channel activator for treatment of chronic constipation.

Ambizas EM, Ginzburg R.

Ann Pharmacother. 2007 Jun;41(6):957-64. Epub 2007 May 22. Review.

PMID:
17519292
9.
10.

Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone.

Moeser AJ, Nighot PK, Engelke KJ, Ueno R, Blikslager AT.

Am J Physiol Gastrointest Liver Physiol. 2007 Feb;292(2):G647-56. Epub 2006 Oct 19.

11.

Acinar origin of CFTR-dependent airway submucosal gland fluid secretion.

Wu JV, Krouse ME, Wine JJ.

Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L304-11. Epub 2006 Sep 22.

12.

Expression of the chloride channel CLC-K in human airway epithelial cells.

Mummery JL, Killey J, Linsdell P.

Can J Physiol Pharmacol. 2005 Dec;83(12):1123-8.

PMID:
16462912
13.

Hyposecretion, not hyperabsorption, is the basic defect of cystic fibrosis airway glands.

Joo NS, Irokawa T, Robbins RC, Wine JJ.

J Biol Chem. 2006 Mar 17;281(11):7392-8. Epub 2006 Jan 12.

14.

Submucosal glands and airway defense.

Wine JJ, Joo NS.

Proc Am Thorac Soc. 2004;1(1):47-53. Review.

PMID:
16113412
15.

Characterization of wild-type and deltaF508 cystic fibrosis transmembrane regulator in human respiratory epithelia.

Kreda SM, Mall M, Mengos A, Rochelle L, Yankaskas J, Riordan JR, Boucher RC.

Mol Biol Cell. 2005 May;16(5):2154-67. Epub 2005 Feb 16.

16.

Submucosal gland dysfunction as a primary defect in cystic fibrosis.

Salinas D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson DW, Verkman AS.

FASEB J. 2005 Mar;19(3):431-3. Epub 2004 Dec 13.

PMID:
15596485
17.

ClC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum.

Moeser AJ, Haskell MM, Shifflett DE, Little D, Schultz BD, Blikslager AT.

Gastroenterology. 2004 Sep;127(3):802-15.

PMID:
15362036
18.

Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy.

Muanprasat C, Sonawane ND, Salinas D, Taddei A, Galietta LJ, Verkman AS.

J Gen Physiol. 2004 Aug;124(2):125-37.

19.

SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents.

Cuppoletti J, Malinowska DH, Tewari KP, Li QJ, Sherry AM, Patchen ML, Ueno R.

Am J Physiol Cell Physiol. 2004 Nov;287(5):C1173-83. Epub 2004 Jun 22.

20.

Basolateral ClC-2 chloride channels in surface colon epithelium: regulation by a direct effect of intracellular chloride.

Catalán M, Niemeyer MI, Cid LP, Sepúlveda FV.

Gastroenterology. 2004 Apr;126(4):1104-14.

PMID:
15057749

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