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53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility.

Dimitrova N, Chen YC, Spector DL, de Lange T.

Nature. 2008 Nov 27;456(7221):524-8. doi: 10.1038/nature07433. Epub 2008 Oct 19.


ATR: an essential regulator of genome integrity.

Cimprich KA, Cortez D.

Nat Rev Mol Cell Biol. 2008 Aug;9(8):616-27. doi: 10.1038/nrm2450. Epub 2008 Jul 2. Review.


Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage.

Chapman JR, Jackson SP.

EMBO Rep. 2008 Aug;9(8):795-801. doi: 10.1038/embor.2008.103. Epub 2008 Jun 27.


Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia.

Perfettini JL, Nardacci R, Bourouba M, Subra F, Gros L, Séror C, Manic G, Rosselli F, Amendola A, Masdehors P, Chessa L, Novelli G, Ojcius DM, Siwicki JK, Chechlinska M, Auclair C, Regueiro JR, de Thé H, Gougeon ML, Piacentini M, Kroemer G.

PLoS One. 2008 Jun 18;3(6):e2458. doi: 10.1371/journal.pone.0002458.


Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase.

Jin J, Ang XL, Ye X, Livingstone M, Harper JW.

J Biol Chem. 2008 Jul 11;283(28):19322-8. doi: 10.1074/jbc.M802474200. Epub 2008 May 13.


Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies.

Zeng Y, Sankala H, Zhang X, Graves PR.

Biochem J. 2008 Aug 1;413(3):429-36. doi: 10.1042/BJ20080599.


Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.

Spycher C, Miller ES, Townsend K, Pavic L, Morrice NA, Janscak P, Stewart GS, Stucki M.

J Cell Biol. 2008 Apr 21;181(2):227-40. doi: 10.1083/jcb.200709008. Epub 2008 Apr 14.


The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2.

Maitra S, Chou CF, Luber CA, Lee KY, Mann M, Chen CY.

RNA. 2008 May;14(5):950-9. doi: 10.1261/rna.983708. Epub 2008 Mar 6.


Activation of Srk1 by the mitogen-activated protein kinase Sty1/Spc1 precedes its dissociation from the kinase and signals its degradation.

López-Avilés S, Lambea E, Moldón A, Grande M, Fajardo A, Rodríguez-Gabriel MA, Hidalgo E, Aligue R.

Mol Biol Cell. 2008 Apr;19(4):1670-9. doi: 10.1091/mbc.E07-07-0639. Epub 2008 Feb 13.


GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.

Kang T, Wei Y, Honaker Y, Yamaguchi H, Appella E, Hung MC, Piwnica-Worms H.

Cancer Cell. 2008 Jan;13(1):36-47. doi: 10.1016/j.ccr.2007.12.002.


Human immunodeficiency virus type 1 Vpr induces cell cycle G2 arrest through Srk1/MK2-mediated phosphorylation of Cdc25.

Huard S, Elder RT, Liang D, Li G, Zhao RY.

J Virol. 2008 Mar;82(6):2904-17. Epub 2007 Dec 26.


Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.

Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R.

Mol Cell. 2007 Dec 28;28(6):1045-57.


The DNA damage response: ten years after.

Harper JW, Elledge SJ.

Mol Cell. 2007 Dec 14;28(5):739-45. Review.


Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.

Wang B, Elledge SJ.

Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20759-63. Epub 2007 Dec 5.


Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.

Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D.

Science. 2007 Dec 7;318(5856):1637-40. Epub 2007 Nov 15.


RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J.

Cell. 2007 Nov 30;131(5):901-14. Epub 2007 Nov 20.


RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J.

Cell. 2007 Nov 30;131(5):887-900. Epub 2007 Nov 20.


Human CtIP promotes DNA end resection.

Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP.

Nature. 2007 Nov 22;450(7169):509-14. Epub 2007 Oct 28.


DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.

Sun Y, Xu Y, Roy K, Price BD.

Mol Cell Biol. 2007 Dec;27(24):8502-9. Epub 2007 Oct 8.


Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response.

Gorrini C, Squatrito M, Luise C, Syed N, Perna D, Wark L, Martinato F, Sardella D, Verrecchia A, Bennett S, Confalonieri S, Cesaroni M, Marchesi F, Gasco M, Scanziani E, Capra M, Mai S, Nuciforo P, Crook T, Lough J, Amati B.

Nature. 2007 Aug 30;448(7157):1063-7.


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