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Items: 1 to 20 of 43

1.

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity.

Odegard JM, Marks BR, DiPlacido LD, Poholek AC, Kono DH, Dong C, Flavell RA, Craft J.

J Exp Med. 2008 Nov 24;205(12):2873-86. doi: 10.1084/jem.20080840. Epub 2008 Nov 3.

2.

A fundamental role for interleukin-21 in the generation of T follicular helper cells.

Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, King C.

Immunity. 2008 Jul 18;29(1):127-37. doi: 10.1016/j.immuni.2008.06.001. Epub 2008 Jul 3.

3.

IL-21 and autoimmune disease--hypothesis and reality?

Holmdahl R.

Eur J Immunol. 2008 Jul;38(7):1800-2. doi: 10.1002/eji.200838529.

4.

IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo.

Sonderegger I, Kisielow J, Meier R, King C, Kopf M.

Eur J Immunol. 2008 Jul;38(7):1833-8. doi: 10.1002/eji.200838511.

5.

Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis.

Coquet JM, Chakravarti S, Smyth MJ, Godfrey DI.

J Immunol. 2008 Jun 1;180(11):7097-101.

6.

Development and characterization of IL-21-producing CD4+ T cells.

Suto A, Kashiwakuma D, Kagami S, Hirose K, Watanabe N, Yokote K, Saito Y, Nakayama T, Grusby MJ, Iwamoto I, Nakajima H.

J Exp Med. 2008 Jun 9;205(6):1369-79. doi: 10.1084/jem.20072057. Epub 2008 May 12.

7.

T follicular helper (TFH) cells in normal and dysregulated immune responses.

King C, Tangye SG, Mackay CR.

Annu Rev Immunol. 2008;26:741-66. doi: 10.1146/annurev.immunol.26.021607.090344. Review.

PMID:
18173374
8.

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA.

Yu D, Tan AH, Hu X, Athanasopoulos V, Simpson N, Silva DG, Hutloff A, Giles KM, Leedman PJ, Lam KP, Goodnow CC, Vinuesa CG.

Nature. 2007 Nov 8;450(7167):299-303. doi: 10.1038/nature06253. Erratum in: Nature. 2008 Feb 21;451(7181):1022.

PMID:
18172933
9.

Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.

Hsu HC, Yang P, Wang J, Wu Q, Myers R, Chen J, Yi J, Guentert T, Tousson A, Stanus AL, Le TV, Lorenz RG, Xu H, Kolls JK, Carter RH, Chaplin DD, Williams RW, Mountz JD.

Nat Immunol. 2008 Feb;9(2):166-75. Epub 2007 Dec 23.

PMID:
18157131
10.

Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells.

Bryant VL, Ma CS, Avery DT, Li Y, Good KL, Corcoran LM, de Waal Malefyt R, Tangye SG.

J Immunol. 2007 Dec 15;179(12):8180-90.

11.

Interleukin-21: basic biology and implications for cancer and autoimmunity.

Spolski R, Leonard WJ.

Annu Rev Immunol. 2008;26:57-79. Review.

PMID:
17953510
12.

Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus.

Bubier JA, Bennett SM, Sproule TJ, Lyons BL, Olland S, Young DA, Roopenian DC.

Ann N Y Acad Sci. 2007 Sep;1110:590-601.

PMID:
17911475
13.

Monocytosis in BXSB mice is due to epistasis between Yaa and the telomeric region of chromosome 1 but does not drive the disease process.

Rogers NJ, Gabriel L, Nunes CT, Rose SJ, Thiruudaian V, Boyle J, Morley BJ.

Genes Immun. 2007 Dec;8(8):619-27. Epub 2007 Aug 30.

PMID:
17728791
14.

Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus.

Sawalha AH, Kaufman KM, Kelly JA, Adler AJ, Aberle T, Kilpatrick J, Wakeland EK, Li QZ, Wandstrat AE, Karp DR, James JA, Merrill JT, Lipsky P, Harley JB.

Ann Rheum Dis. 2008 Apr;67(4):458-61. Epub 2007 Aug 24.

PMID:
17720724
15.

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells.

Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C.

Nature. 2007 Jul 26;448(7152):480-3. Epub 2007 Jun 20.

PMID:
17581589
16.

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.

Korn T, Bettelli E, Gao W, Awasthi A, J├Ąger A, Strom TB, Oukka M, Kuchroo VK.

Nature. 2007 Jul 26;448(7152):484-487. doi: 10.1038/nature05970. Epub 2007 Jun 20.

17.

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.

Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR.

Nat Immunol. 2007 Sep;8(9):967-74. Epub 2007 Jun 20.

PMID:
17581537
18.

Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis.

Young DA, Hegen M, Ma HL, Whitters MJ, Albert LM, Lowe L, Senices M, Wu PW, Sibley B, Leathurby Y, Brown TP, Nickerson-Nutter C, Keith JC Jr, Collins M.

Arthritis Rheum. 2007 Apr;56(4):1152-63.

19.

IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.

Herber D, Brown TP, Liang S, Young DA, Collins M, Dunussi-Joannopoulos K.

J Immunol. 2007 Mar 15;178(6):3822-30.

20.

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