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Items: 12


A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity.

Vallerie SN, Furuhashi M, Fucho R, Hotamisligil GS.

PLoS One. 2008 Sep 5;3(9):e3151. doi: 10.1371/journal.pone.0003151. Erratum in: PLoS ONE. 2009;4(1). doi: 10.1371/annotation/1074cd39-708b-45ef-943a-e9d1c5bbdedd.


Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice.

Furuhashi M, Fucho R, Görgün CZ, Tuncman G, Cao H, Hotamisligil GS.

J Clin Invest. 2008 Jul;118(7):2640-50. doi: 10.1172/JCI34750.


Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease.

Gregor MF, Hotamisligil GS.

J Lipid Res. 2007 Sep;48(9):1905-14. Epub 2007 May 9. Review.


Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS.

Nature. 2007 Jun 21;447(7147):959-65. Epub 2007 Jun 6.


Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis.

Wellen KE, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GS.

Cell. 2007 May 4;129(3):537-48.


Inflammation and metabolic disorders.

Hotamisligil GS.

Nature. 2006 Dec 14;444(7121):860-7. Review.


Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.

Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ, Hotamisligil GS.

Science. 2006 Aug 25;313(5790):1137-40.


Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.

Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS.

Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10741-6. Epub 2006 Jul 3.


Inflammation, stress, and diabetes.

Wellen KE, Hotamisligil GS.

J Clin Invest. 2005 May;115(5):1111-9. Review.


Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Görgün C, Glimcher LH, Hotamisligil GS.

Science. 2004 Oct 15;306(5695):457-61.


A central role for JNK in obesity and insulin resistance.

Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS.

Nature. 2002 Nov 21;420(6913):333-6.


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