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Metformin, arterial function, intima-media thickness and nitroxidation in metabolic syndrome: the mefisto study.

Meaney E, Vela A, Samaniego V, Meaney A, Asbún J, Zempoalteca JC, Elisa ZN, Emma MN, Guzman M, Hicks J, Ceballos G.

Clin Exp Pharmacol Physiol. 2008 Aug;35(8):895-903. doi: 10.1111/j.1440-1681.2008.04920.x.


Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.

Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, Hailpern SM, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell C, Roger V, Sorlie P, Steinberger J, Thom T, Wilson M, Hong Y; American Heart Association Statistics Committee and Stroke Statistics Subcommittee..

Circulation. 2008 Jan 29;117(4):e25-146. No abstract available. Erratum in: Circulation. 2010 Jul 6;122(1):e10. Kissela, Bret [corrected to Kissela, Brett].


Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling.

Calvert JW, Gundewar S, Jha S, Greer JJ, Bestermann WH, Tian R, Lefer DJ.

Diabetes. 2008 Mar;57(3):696-705.


Metformin in heart failure.

Inzucchi SE, Masoudi FA, McGuire DK.

Diabetes Care. 2007 Dec;30(12):e129. No abstract available.


Inhibition of N-ethylmaleimide-sensitive factor protects against myocardial ischemia/reperfusion injury.

Calvert JW, Gundewar S, Yamakuchi M, Park PC, Baldwin WM 3rd, Lefer DJ, Lowenstein CJ.

Circ Res. 2007 Dec 7;101(12):1247-54.


Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function.

Elrod JW, Calvert JW, Morrison J, Doeller JE, Kraus DW, Tao L, Jiao X, Scalia R, Kiss L, Szabo C, Kimura H, Chow CW, Lefer DJ.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15560-5.


Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review.

Eurich DT, McAlister FA, Blackburn DF, Majumdar SR, Tsuyuki RT, Varney J, Johnson JA.

BMJ. 2007 Sep 8;335(7618):497. Review.


Cytoprotective effects of N,N,N-trimethylsphingosine during ischemia- reperfusion injury are lost in the setting of obesity and diabetes.

Gundewar S, Calvert JW, Elrod JW, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2462-71.


AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.

Jäger S, Handschin C, St-Pierre J, Spiegelman BM.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12017-22.


The safety of metformin in heart failure.

Roberts F, Ryan GJ.

Ann Pharmacother. 2007 Apr;41(4):642-6. Review.


Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration.

Zhang L, He H, Balschi JA.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H457-66.


PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.

Finck BN, Kelly DP.

J Clin Invest. 2006 Mar;116(3):615-22. Review.


AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B.

Bertrand L, Ginion A, Beauloye C, Hebert AD, Guigas B, Hue L, Vanoverschelde JL.

Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H239-50.


Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.

Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, Spiegelman BM.

Cell Metab. 2005 Apr;1(4):259-71.


Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals.

Nisoli E, Falcone S, Tonello C, Cozzi V, Palomba L, Fiorani M, Pisconti A, Brunelli S, Cardile A, Francolini M, Cantoni O, Carruba MO, Moncada S, Clementi E.

Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16507-12. Erratum in: Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5635.


The AMP-activated protein kinase pathway--new players upstream and downstream.

Hardie DG.

J Cell Sci. 2004 Nov 1;117(Pt 23):5479-87. Review.


AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury.

Russell RR 3rd, Li J, Coven DL, Pypaert M, Zechner C, Palmeri M, Giordano FJ, Mu J, Birnbaum MJ, Young LH.

J Clin Invest. 2004 Aug;114(4):495-503.

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