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The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels.

Barrett CF, Tsien RW.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2157-62. doi: 10.1073/pnas.0710501105. Epub 2008 Feb 4.


The separation of antagonist from agonist effects of trisubstituted purines on CaV2.2 (N-type) channels.

Buraei Z, Elmslie KS.

J Neurochem. 2008 May;105(4):1450-61. doi: 10.1111/j.1471-4159.2008.05248.x. Epub 2008 Jan 23.


A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates.

Mahajan A, Shiferaw Y, Sato D, Baher A, Olcese R, Xie LH, Yang MJ, Chen PS, Restrepo JG, Karma A, Garfinkel A, Qu Z, Weiss JN.

Biophys J. 2008 Jan 15;94(2):392-410.


L-type Ca2+ channel mutations and T-wave alternans: a model study.

Zhu ZI, Clancy CE.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3480-9. Epub 2007 Oct 12.


Cellular basis for the electrocardiographic and arrhythmic manifestations of Timothy syndrome: effects of ranolazine.

Sicouri S, Timothy KW, Zygmunt AC, Glass A, Goodrow RJ, Belardinelli L, Antzelevitch C.

Heart Rhythm. 2007 May;4(5):638-47. Epub 2007 Jan 7.


Calcium and arrhythmogenesis.

Ter Keurs HE, Boyden PA.

Physiol Rev. 2007 Apr;87(2):457-506. Review.


A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days.

Benson C, White J, De Bono J, O'Donnell A, Raynaud F, Cruickshank C, McGrath H, Walton M, Workman P, Kaye S, Cassidy J, Gianella-Borradori A, Judson I, Twelves C.

Br J Cancer. 2007 Jan 15;96(1):29-37. Epub 2006 Dec 19.


Kinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation.

Faber GM, Silva J, Livshitz L, Rudy Y.

Biophys J. 2007 Mar 1;92(5):1522-43. Epub 2006 Dec 8.


Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block.

Antoons G, Volders PG, Stankovicova T, Bito V, Stengl M, Vos MA, Sipido KR.

J Physiol. 2007 Feb 15;579(Pt 1):147-60. Epub 2006 Nov 30.


Roscovitine differentially affects CaV2 and Kv channels by binding to the open state.

Buraei Z, Schofield G, Elmslie KS.

Neuropharmacology. 2007 Mar;52(3):883-94. Epub 2006 Nov 27.


Effects of L-type Ca2+ channel antagonism on ventricular arrhythmogenesis in murine hearts containing a modification in the Scn5a gene modelling human long QT syndrome 3.

Thomas G, Gurung IS, Killeen MJ, Hakim P, Goddard CA, Mahaut-Smith MP, Colledge WH, Grace AA, Huang CL.

J Physiol. 2007 Jan 1;578(Pt 1):85-97. Epub 2006 Nov 16.


The role of the GX9GX3G motif in the gating of high voltage-activated Ca2+ channels.

Raybaud A, Dodier Y, Bissonnette P, Simoes M, Bichet DG, Sauvé R, Parent L.

J Biol Chem. 2006 Dec 22;281(51):39424-36. Epub 2006 Oct 11.


Verapamil decreases ventricular tachyarrhythmias in a patient with Timothy syndrome (LQT8).

Jacobs A, Knight BP, McDonald KT, Burke MC.

Heart Rhythm. 2006 Aug;3(8):967-70. Epub 2006 Apr 29. No abstract available.


Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices.

Erxleben C, Liao Y, Gentile S, Chin D, Gomez-Alegria C, Mori Y, Birnbaumer L, Armstrong DL.

Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3932-7. Epub 2006 Feb 28.


Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine.

Buraei Z, Anghelescu M, Elmslie KS.

Biophys J. 2005 Sep;89(3):1681-91. Epub 2005 Jun 10.


Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations.

Splawski I, Timothy KW, Decher N, Kumar P, Sachse FB, Beggs AH, Sanguinetti MC, Keating MT.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8089-96; discussion 8086-8. Epub 2005 Apr 29.


The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations.

Tanskanen AJ, Greenstein JL, O'Rourke B, Winslow RL.

Biophys J. 2005 Jan;88(1):85-95. Epub 2004 Oct 22.


Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism.

Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph RM, Condouris K, Tager-Flusberg H, Priori SG, Sanguinetti MC, Keating MT.

Cell. 2004 Oct 1;119(1):19-31.

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