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Items: 1 to 20 of 34

1.

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

Cooper JD, Smyth DJ, Smiles AM, Plagnol V, Walker NM, Allen JE, Downes K, Barrett JC, Healy BC, Mychaleckyj JC, Warram JH, Todd JA.

Nat Genet. 2008 Dec;40(12):1399-401. doi: 10.1038/ng.249. Epub 2008 Nov 2.

2.

CD226 Gly307Ser association with multiple autoimmune diseases.

Hafler JP, Maier LM, Cooper JD, Plagnol V, Hinks A, Simmonds MJ, Stevens HE, Walker NM, Healy B, Howson JM, Maisuria M, Duley S, Coleman G, Gough SC; International Multiple Sclerosis Genetics Consortium (IMSGC), Worthington J, Kuchroo VK, Wicker LS, Todd JA.

Genes Immun. 2009 Jan;10(1):5-10. doi: 10.1038/gene.2008.82. Epub 2008 Oct 30.

3.

The "perfect storm" for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity.

Vaarala O, Atkinson MA, Neu J.

Diabetes. 2008 Oct;57(10):2555-62. doi: 10.2337/db08-0331. Review.

4.

Innate immunity and intestinal microbiota in the development of Type 1 diabetes.

Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC, Hu C, Wong FS, Szot GL, Bluestone JA, Gordon JI, Chervonsky AV.

Nature. 2008 Oct 23;455(7216):1109-13. doi: 10.1038/nature07336. Epub 2008 Sep 21.

5.

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ; NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E; Belgian-French IBD Consortium; Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ.

Nat Genet. 2008 Aug;40(8):955-62. doi: 10.1038/ng.175. Epub 2008 Jun 29.

6.

CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individuals.

Ahuja SK, Kulkarni H, Catano G, Agan BK, Camargo JF, He W, O'Connell RJ, Marconi VC, Delmar J, Eron J, Clark RA, Frost S, Martin J, Ahuja SS, Deeks SG, Little S, Richman D, Hecht FM, Dolan MJ.

Nat Med. 2008 Apr;14(4):413-20. doi: 10.1038/nm1741. Epub 2008 Mar 30.

7.

IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations.

Weber F, Fontaine B, Cournu-Rebeix I, Kroner A, Knop M, Lutz S, Müller-Sarnowski F, Uhr M, Bettecken T, Kohli M, Ripke S, Ising M, Rieckmann P, Brassat D, Semana G, Babron MC, Mrejen S, Gout C, Lyon-Caen O, Yaouanq J, Edan G, Clanet M, Holsboer F, Clerget-Darpoux F, Müller-Myhsok B.

Genes Immun. 2008 Apr;9(3):259-63. doi: 10.1038/gene.2008.14. Epub 2008 Mar 20.

PMID:
18354419
8.

Newly identified genetic risk variants for celiac disease related to the immune response.

Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA.

Nat Genet. 2008 Apr;40(4):395-402. doi: 10.1038/ng.102. Epub 2008 Mar 2.

9.

A unifying hypothesis on the development of type 1 diabetes and celiac disease: gluten consumption may be a shared causative factor.

Frisk G, Hansson T, Dahlbom I, Tuvemo T.

Med Hypotheses. 2008;70(6):1207-9. doi: 10.1016/j.mehy.2007.05.058. Epub 2008 Feb 4.

PMID:
18249499
10.

The functional R620W variant of the PTPN22 gene is associated with celiac disease.

Santin I, Castellanos-Rubio A, Aransay AM, Castaño L, Vitoria JC, Bilbao JR.

Tissue Antigens. 2008 Mar;71(3):247-9. doi: 10.1111/j.1399-0039.2007.01002.x. Epub 2008 Jan 10.

PMID:
18194365
11.

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.

Nejentsev S, Howson JM, Walker NM, Szeszko J, Field SF, Stevens HE, Reynolds P, Hardy M, King E, Masters J, Hulme J, Maier LM, Smyth D, Bailey R, Cooper JD, Ribas G, Campbell RD, Clayton DG, Todd JA; Wellcome Trust Case Control Consortium.

Nature. 2007 Dec 6;450(7171):887-92. Epub 2007 Nov 14.

12.

Increasing prevalence of coeliac disease over time.

Lohi S, Mustalahti K, Kaukinen K, Laurila K, Collin P, Rissanen H, Lohi O, Bravi E, Gasparin M, Reunanen A, Mäki M.

Aliment Pharmacol Ther. 2007 Nov 1;26(9):1217-25.

13.

Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis.

McKinney C, Merriman ME, Chapman PT, Gow PJ, Harrison AA, Highton J, Jones PB, McLean L, O'Donnell JL, Pokorny V, Spellerberg M, Stamp LK, Willis J, Steer S, Merriman TR.

Ann Rheum Dis. 2008 Mar;67(3):409-13. Epub 2007 Jun 29.

PMID:
17604289
14.

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR, Deloukas P, Wijmenga C.

Nat Genet. 2007 Jul;39(7):827-9. Epub 2007 Jun 10.

15.

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Wellcome Trust Case Control Consortium.

Nature. 2007 Jun 7;447(7145):661-78.

16.

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.

Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, Fisher SA, Roberts RG, Nimmo ER, Cummings FR, Soars D, Drummond H, Lees CW, Khawaja SA, Bagnall R, Burke DA, Todhunter CE, Ahmad T, Onnie CM, McArdle W, Strachan D, Bethel G, Bryan C, Lewis CM, Deloukas P, Forbes A, Sanderson J, Jewell DP, Satsangi J, Mansfield JC; Wellcome Trust Case Control Consortium, Cardon L, Mathew CG.

Nat Genet. 2007 Jul;39(7):830-2. Epub 2007 Jun 6.

17.

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam AA, Ovington NR, Allen J, Adlem E, Leung HT, Wallace C, Howson JM, Guja C, Ionescu-Tîrgovişte C; Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SC; Wellcome Trust Case Control Consortium, Dunger DB, Wicker LS, Clayton DG.

Nat Genet. 2007 Jul;39(7):857-64. Epub 2007 Jun 6.

18.

CCL4 protects from type 1 diabetes by altering islet beta-cell-targeted inflammatory responses.

Meagher C, Arreaza G, Peters A, Strathdee CA, Gilbert PA, Mi QS, Santamaria P, Dekaban GA, Delovitch TL.

Diabetes. 2007 Mar;56(3):809-17.

19.

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P.

Nat Genet. 2007 Mar;39(3):329-37. Epub 2007 Feb 4.

20.

Recent advances in coeliac disease.

van Heel DA, West J.

Gut. 2006 Jul;55(7):1037-46. Review. No abstract available.

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