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Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.

Riccio O, van Gijn ME, Bezdek AC, Pellegrinet L, van Es JH, Zimber-Strobl U, Strobl LJ, Honjo T, Clevers H, Radtke F.

EMBO Rep. 2008 Apr;9(4):377-83. doi: 10.1038/embor.2008.7. Epub 2008 Feb 15.


Differential Notch and TGFbeta signaling in primary colorectal tumors and their corresponding metastases.

Veenendaal LM, Kranenburg O, Smakman N, Klomp A, Borel Rinkes IH, van Diest PJ.

Cell Oncol. 2008;30(1):1-11.


Wnt/Notch signalling and information processing during development.

Hayward P, Kalmar T, Arias AM.

Development. 2008 Feb;135(3):411-24. doi: 10.1242/dev.000505. Review.


Gamma-secretase inhibitors enhance taxane-induced mitotic arrest and apoptosis in colon cancer cells.

Akiyoshi T, Nakamura M, Yanai K, Nagai S, Wada J, Koga K, Nakashima H, Sato N, Tanaka M, Katano M.

Gastroenterology. 2008 Jan;134(1):131-44. doi: 10.1053/j.gastro.2007.10.008. Epub 2007 Oct 9.


Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry.

Poynter JN, Figueiredo JC, Conti DV, Kennedy K, Gallinger S, Siegmund KD, Casey G, Thibodeau SN, Jenkins MA, Hopper JL, Byrnes GB, Baron JA, Goode EL, Tiirikainen M, Lindor N, Grove J, Newcomb P, Jass J, Young J, Potter JD, Haile RW, Duggan DJ, Le Marchand L; Colon CFR.

Cancer Res. 2007 Dec 1;67(23):11128-32.


Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancer.

Newcomb PA, Baron J, Cotterchio M, Gallinger S, Grove J, Haile R, Hall D, Hopper JL, Jass J, Le Marchand L, Limburg P, Lindor N, Potter JD, Templeton AS, Thibodeau S, Seminara D; Colon Cancer Family Registry.

Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2331-43. Epub 2007 Nov 2.


Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors.

Kosinski C, Li VS, Chan AS, Zhang J, Ho C, Tsui WY, Chan TL, Mifflin RC, Powell DW, Yuen ST, Leung SY, Chen X.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15418-23. Epub 2007 Sep 19.


Notch signaling in vascular development and physiology.

Gridley T.

Development. 2007 Aug;134(15):2709-18. Epub 2007 Jul 4. Review.


High-level JAG1 mRNA and protein predict poor outcome in breast cancer.

Dickson BC, Mulligan AM, Zhang H, Lockwood G, O'Malley FP, Egan SE, Reedijk M.

Mod Pathol. 2007 Jun;20(6):685-93.


Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE.

Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, Kopan R.

Development. 2007 Feb;134(3):535-44.


Notch signaling in stem cell systems.

Chiba S.

Stem Cells. 2006 Nov;24(11):2437-47. Epub 2006 Aug 3. Review.


The long and short of it: somite formation in mice.

Gridley T.

Dev Dyn. 2006 Sep;235(9):2330-6. Review.


A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma.

Leow CC, Polakis P, Gao WQ.

Ann N Y Acad Sci. 2005 Nov;1059:174-83. Review.


Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease.

van Es JH, Clevers H.

Trends Mol Med. 2005 Nov;11(11):496-502. Epub 2005 Oct 7. Review.


High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival.

Reedijk M, Odorcic S, Chang L, Zhang H, Miller N, McCready DR, Lockwood G, Egan SE.

Cancer Res. 2005 Sep 15;65(18):8530-7.


Direct regulation of intestinal fate by Notch.

Stanger BZ, Datar R, Murtaugh LC, Melton DA.

Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12443-8. Epub 2005 Aug 17.


Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells.

Zecchini V, Domaschenz R, Winton D, Jones P.

Genes Dev. 2005 Jul 15;19(14):1686-91.


EphB receptor activity suppresses colorectal cancer progression.

Batlle E, Bacani J, Begthel H, Jonkheer S, Gregorieff A, van de Born M, Malats N, Sancho E, Boon E, Pawson T, Gallinger S, Pals S, Clevers H.

Nature. 2005 Jun 23;435(7045):1126-30. Erratum in: Nature. 2005 Aug 11;436(7052):881. Jonkeer, Suzanne [corrected to Jonkheer, Suzanne].


Notch signals control the fate of immature progenitor cells in the intestine.

Fre S, Huyghe M, Mourikis P, Robine S, Louvard D, Artavanis-Tsakonas S.

Nature. 2005 Jun 16;435(7044):964-8.


Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.

van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H.

Nature. 2005 Jun 16;435(7044):959-63.


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