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Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation.

Kelly RM, Highfill SL, Panoskaltsis-Mortari A, Taylor PA, Boyd RL, Holländer GA, Blazar BR.

Blood. 2008 Jun 15;111(12):5734-44. doi: 10.1182/blood-2008-01-136531.


Mechanisms of immunization against cancer using chimeric antigens.

Engelhorn ME, Guevara-Patiño JA, Merghoub T, Liu C, Ferrone CR, Rizzuto GA, Cymerman DH, Posnett DN, Houghton AN, Wolchok JD.

Mol Ther. 2008 Apr;16(4):773-81. doi: 10.1038/mt.2008.8.


Enhanced immune system regeneration in humans following allogeneic or autologous hemopoietic stem cell transplantation by temporary sex steroid blockade.

Sutherland JS, Spyroglou L, Muirhead JL, Heng TS, Prieto-Hinojosa A, Prince HM, Chidgey AP, Schwarer AP, Boyd RL.

Clin Cancer Res. 2008 Feb 15;14(4):1138-49. doi: 10.1158/1078-0432.CCR-07-1784.


Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor.

Guimond M, Leonard WJ, Spolski R, Rossi SW, Veenstra RG, Hollander GA, Mackall CL, Blazar BR.

Blood. 2008 Jan 15;111(2):969-70. doi: 10.1182/blood-2007-09-113316. No abstract available.


Keratinocyte growth factor induces expansion of murine peripheral CD4+Foxp3+ regulatory T cells and increases their thymic output.

Bruinsma M, van Soest PL, Leenen PJ, Lambrecht BN, Cupedo T, Löwenberg B, Cornelissen JJ, Braakman E.

J Immunol. 2007 Dec 1;179(11):7424-30.


T cell immune reconstitution following lymphodepletion.

Williams KM, Hakim FT, Gress RE.

Semin Immunol. 2007 Oct;19(5):318-30. Review.


Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation.

Sarkar S, Teichgräber V, Kalia V, Polley A, Masopust D, Harrington LE, Ahmed R, Wherry EJ.

J Immunol. 2007 Nov 15;179(10):6704-14.


Clinical strategies to enhance T cell reconstitution.

Goldberg GL, Zakrzewski JL, Perales MA, van den Brink MR.

Semin Immunol. 2007 Oct;19(5):289-96. Review.


Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover.

Almeida JR, Price DA, Papagno L, Arkoub ZA, Sauce D, Bornstein E, Asher TE, Samri A, Schnuriger A, Theodorou I, Costagliola D, Rouzioux C, Agut H, Marcelin AG, Douek D, Autran B, Appay V.

J Exp Med. 2007 Oct 1;204(10):2473-85.


Absolute lymphocyte count predicts therapeutic efficacy and survival at the time of radioimmunotherapy in patients with relapsed follicular lymphomas.

Porrata LF, Ristow K, Witzig TE, Tuinistra N, Habermann TM, Inwards DJ, Ansell SM, Micallef IN, Johnston PB, Markovic SN.

Leukemia. 2007 Dec;21(12):2554-6. No abstract available.


Immunological validation of the EpitOptimizer program for streamlined design of heteroclitic epitopes.

Houghton CS, Engelhorn ME, Liu C, Song D, Gregor P, Livingston PO, Orlandi F, Wolchok JD, McCracken J, Houghton AN, Guevara-Patiño JA.

Vaccine. 2007 Jul 20;25(29):5330-42.


Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.

Seggewiss R, Loré K, Guenaga FJ, Pittaluga S, Mattapallil J, Chow CK, Koup RA, Camphausen K, Nason MC, Meier-Schellersheim M, Donahue RE, Blazar BR, Dunbar CE, Douek DC.

Blood. 2007 Jul 1;110(1):441-9.


Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.

Rossi SW, Jeker LT, Ueno T, Kuse S, Keller MP, Zuklys S, Gudkov AV, Takahama Y, Krenger W, Blazar BR, Holländer GA.

Blood. 2007 May 1;109(9):3803-11.


Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging.

Min D, Panoskaltsis-Mortari A, Kuro-O M, Holländer GA, Blazar BR, Weinberg KI.

Blood. 2007 Mar 15;109(6):2529-37.


DNA immunization against tissue-restricted antigens enhances tumor immunity after allogeneic hemopoietic stem cell transplantation.

Perales MA, Diab A, Cohen AD, Huggins DW, Guevara-Patiño JA, Hubbard VM, Engelhorn ME, Kochman AA, Eng JM, Mortazavi F, Alpdogan O, Terwey TH, Heller G, Wolchok JD, Houghton AN, van den Brink MR.

J Immunol. 2006 Sep 15;177(6):4159-67.


Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy.

Hick RW, Gruver AL, Ventevogel MS, Haynes BF, Sempowski GD.

J Immunol. 2006 Jul 1;177(1):169-76.

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