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Items: 1 to 20 of 23

1.

Trex1 prevents cell-intrinsic initiation of autoimmunity.

Stetson DB, Ko JS, Heidmann T, Medzhitov R.

Cell. 2008 Aug 22;134(4):587-98. doi: 10.1016/j.cell.2008.06.032.

2.

New roles for the major human 3'-5' exonuclease TREX1 in human disease.

Kavanagh D, Spitzer D, Kothari PH, Shaikh A, Liszewski MK, Richards A, Atkinson JP.

Cell Cycle. 2008 Jun 15;7(12):1718-25. Epub 2008 Jun 16. Review.

3.

Cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease.

Perrino FW, de Silva U, Harvey S, Pryor EE Jr, Cole DW, Hollis T.

J Biol Chem. 2008 Aug 1;283(31):21441-52. doi: 10.1074/jbc.M803629200. Epub 2008 Jun 5.

4.

Cutaneous histopathological findings of Aicardi-Goutières syndrome, overlap with chilblain lupus.

Kolivras A, Aeby A, Crow YJ, Rice GI, Sass U, André J.

J Cutan Pathol. 2008 Aug;35(8):774-8. doi: 10.1111/j.1600-0560.2007.00900.x. Epub 2008 Apr 17.

PMID:
18422690
5.

Death by a thousand cuts: granzyme pathways of programmed cell death.

Chowdhury D, Lieberman J.

Annu Rev Immunol. 2008;26:389-420. doi: 10.1146/annurev.immunol.26.021607.090404. Review.

6.
7.

Clinical and molecular phenotype of Aicardi-Goutieres syndrome.

Rice G, Patrick T, Parmar R, Taylor CF, Aeby A, Aicardi J, Artuch R, Montalto SA, Bacino CA, Barroso B, Baxter P, Benko WS, Bergmann C, Bertini E, Biancheri R, Blair EM, Blau N, Bonthron DT, Briggs T, Brueton LA, Brunner HG, Burke CJ, Carr IM, Carvalho DR, Chandler KE, Christen HJ, Corry PC, Cowan FM, Cox H, D'Arrigo S, Dean J, De Laet C, De Praeter C, Dery C, Ferrie CD, Flintoff K, Frints SG, Garcia-Cazorla A, Gener B, Goizet C, Goutieres F, Green AJ, Guet A, Hamel BC, Hayward BE, Heiberg A, Hennekam RC, Husson M, Jackson AP, Jayatunga R, Jiang YH, Kant SG, Kao A, King MD, Kingston HM, Klepper J, van der Knaap MS, Kornberg AJ, Kotzot D, Kratzer W, Lacombe D, Lagae L, Landrieu PG, Lanzi G, Leitch A, Lim MJ, Livingston JH, Lourenco CM, Lyall EG, Lynch SA, Lyons MJ, Marom D, McClure JP, McWilliam R, Melancon SB, Mewasingh LD, Moutard ML, Nischal KK, Ostergaard JR, Prendiville J, Rasmussen M, Rogers RC, Roland D, Rosser EM, Rostasy K, Roubertie A, Sanchis A, Schiffmann R, Scholl-Burgi S, Seal S, Shalev SA, Corcoles CS, Sinha GP, Soler D, Spiegel R, Stephenson JB, Tacke U, Tan TY, Till M, Tolmie JL, Tomlin P, Vagnarelli F, Valente EM, Van Coster RN, Van der Aa N, Vanderver A, Vles JS, Voit T, Wassmer E, Weschke B, Whiteford ML, Willemsen MA, Zankl A, Zuberi SM, Orcesi S, Fazzi E, Lebon P, Crow YJ.

Am J Hum Genet. 2007 Oct;81(4):713-25. Epub 2007 Sep 4.

8.

C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy.

Richards A, van den Maagdenberg AM, Jen JC, Kavanagh D, Bertram P, Spitzer D, Liszewski MK, Barilla-Labarca ML, Terwindt GM, Kasai Y, McLellan M, Grand MG, Vanmolkot KR, de Vries B, Wan J, Kane MJ, Mamsa H, Schäfer R, Stam AH, Haan J, de Jong PT, Storimans CW, van Schooneveld MJ, Oosterhuis JA, Gschwendter A, Dichgans M, Kotschet KE, Hodgkinson S, Hardy TA, Delatycki MB, Hajj-Ali RA, Kothari PH, Nelson SF, Frants RR, Baloh RW, Ferrari MD, Atkinson JP.

Nat Genet. 2007 Sep;39(9):1068-70. Epub 2007 Jul 29.

PMID:
17660820
9.

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

Lee-Kirsch MA, Gong M, Chowdhury D, Senenko L, Engel K, Lee YA, de Silva U, Bailey SL, Witte T, Vyse TJ, Kere J, Pfeiffer C, Harvey S, Wong A, Koskenmies S, Hummel O, Rohde K, Schmidt RE, Dominiczak AF, Gahr M, Hollis T, Perrino FW, Lieberman J, Hübner N.

Nat Genet. 2007 Sep;39(9):1065-7. Epub 2007 Jul 29.

PMID:
17660818
10.

A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus.

Lee-Kirsch MA, Chowdhury D, Harvey S, Gong M, Senenko L, Engel K, Pfeiffer C, Hollis T, Gahr M, Perrino FW, Lieberman J, Hubner N.

J Mol Med (Berl). 2007 May;85(5):531-7. Epub 2007 Apr 18.

PMID:
17440703
11.

Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.

Rice G, Newman WG, Dean J, Patrick T, Parmar R, Flintoff K, Robins P, Harvey S, Hollis T, O'Hara A, Herrick AL, Bowden AP, Perrino FW, Lindahl T, Barnes DE, Crow YJ.

Am J Hum Genet. 2007 Apr;80(4):811-5. Epub 2007 Feb 19.

12.

Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains.

Brucet M, Querol-Audí J, Serra M, Ramirez-Espain X, Bertlik K, Ruiz L, Lloberas J, Macias MJ, Fita I, Celada A.

J Biol Chem. 2007 May 11;282(19):14547-57. Epub 2007 Mar 13.

13.

The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.

de Silva U, Choudhury S, Bailey SL, Harvey S, Perrino FW, Hollis T.

J Biol Chem. 2007 Apr 6;282(14):10537-43. Epub 2007 Feb 9.

14.

Familial chilblain lupus, a monogenic form of cutaneous lupus erythematosus, maps to chromosome 3p.

Lee-Kirsch MA, Gong M, Schulz H, Rüschendorf F, Stein A, Pfeiffer C, Ballarini A, Gahr M, Hubner N, Linné M.

Am J Hum Genet. 2006 Oct;79(4):731-7. Epub 2006 Aug 17.

15.

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus.

Crow YJ, Hayward BE, Parmar R, Robins P, Leitch A, Ali M, Black DN, van Bokhoven H, Brunner HG, Hamel BC, Corry PC, Cowan FM, Frints SG, Klepper J, Livingston JH, Lynch SA, Massey RF, Meritet JF, Michaud JL, Ponsot G, Voit T, Lebon P, Bonthron DT, Jackson AP, Barnes DE, Lindahl T.

Nat Genet. 2006 Aug;38(8):917-20. Epub 2006 Jul 16.

PMID:
16845398
16.

The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.

Chowdhury D, Beresford PJ, Zhu P, Zhang D, Sung JS, Demple B, Perrino FW, Lieberman J.

Mol Cell. 2006 Jul 7;23(1):133-42.

17.

The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis.

Perrino FW, Harvey S, McMillin S, Hollis T.

J Biol Chem. 2005 Apr 15;280(15):15212-8. Epub 2005 Jan 19.

18.

Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.

Morita M, Stamp G, Robins P, Dulic A, Rosewell I, Hrivnak G, Daly G, Lindahl T, Barnes DE.

Mol Cell Biol. 2004 Aug;24(15):6719-27.

19.

Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins.

Mazur DJ, Perrino FW.

J Biol Chem. 2001 May 18;276(20):17022-9. Epub 2001 Mar 6.

20.

Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes.

Mazur DJ, Perrino FW.

J Biol Chem. 2001 May 4;276(18):14718-27. Epub 2001 Jan 29.

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