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Items: 1 to 20 of 52


Active gamma-secretase complexes contain only one of each component.

Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS.

J Biol Chem. 2007 Nov 23;282(47):33985-93. Epub 2007 Oct 2.


Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.

Haass C, Selkoe DJ.

Nat Rev Mol Cell Biol. 2007 Feb;8(2):101-12. Review.


Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

Sato C, Morohashi Y, Tomita T, Iwatsubo T.

J Neurosci. 2006 Nov 15;26(46):12081-8.


Notch signalling: a simple pathway becomes complex.

Bray SJ.

Nat Rev Mol Cell Biol. 2006 Sep;7(9):678-89. Review.


Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes.

Clarke EE, Churcher I, Ellis S, Wrigley JD, Lewis HD, Harrison T, Shearman MS, Beher D.

J Biol Chem. 2006 Oct 20;281(42):31279-89. Epub 2006 Aug 9.


Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.

Tolia A, Chávez-Gutiérrez L, De Strooper B.

J Biol Chem. 2006 Sep 15;281(37):27633-42. Epub 2006 Jul 14.


Dimeric organization of the yeast oligosaccharyl transferase complex.

Chavan M, Chen Z, Li G, Schindelin H, Lennarz WJ, Li H.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):8947-52. Epub 2006 Jun 5.


Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores.

Lazarov VK, Fraering PC, Ye W, Wolfe MS, Selkoe DJ, Li H.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):6889-94. Epub 2006 Apr 24.


Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy.

Herl L, Lleo A, Thomas AV, Nyborg AC, Jansen K, Golde TE, Hyman BT, Berezovska O.

Biochem Biophys Res Commun. 2006 Feb 10;340(2):668-74. Epub 2005 Dec 20.


Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1.

Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T.

J Biol Chem. 2005 Dec 23;280(51):41967-75. Epub 2005 Oct 18.


Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2.

Kim SH, Sisodia SS.

J Biol Chem. 2005 Dec 23;280(51):41953-66. Epub 2005 Oct 18.


gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain.

Zhao G, Cui MZ, Mao G, Dong Y, Tan J, Sun L, Xu X.

J Biol Chem. 2005 Nov 11;280(45):37689-97. Epub 2005 Sep 12.


Uncovering gamma-secretase.

Steiner H.

Curr Alzheimer Res. 2004 Aug;1(3):175-81. Review.


Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, Dolios G, Hirotani N, Horikoshi Y, Kametani F, Maeda M, Saido TC, Wang R, Ihara Y.

J Neurosci. 2005 Jan 12;25(2):436-45.


Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

Niimura M, Isoo N, Takasugi N, Tsuruoka M, Ui-Tei K, Saigo K, Morohashi Y, Tomita T, Iwatsubo T.

J Biol Chem. 2005 Apr 1;280(13):12967-75. Epub 2005 Jan 11.


Gamma-secretase complex assembly within the early secretory pathway.

Capell A, Beher D, Prokop S, Steiner H, Kaether C, Shearman MS, Haass C.

J Biol Chem. 2005 Feb 25;280(8):6471-8. Epub 2004 Dec 10.


The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.

Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, Haass C.

EMBO J. 2004 Dec 8;23(24):4738-48. Epub 2004 Nov 18.


Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity.

Hébert SS, Serneels L, Dejaegere T, Horré K, Dabrowski M, Baert V, Annaert W, Hartmann D, De Strooper B.

Neurobiol Dis. 2004 Nov;17(2):260-72.


Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway.

Kim SH, Yin YI, Li YM, Sisodia SS.

J Biol Chem. 2004 Nov 19;279(47):48615-9. Epub 2004 Sep 29.

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