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Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1.

Petronczki M, Lénárt P, Peters JM.

Dev Cell. 2008 May;14(5):646-59. doi: 10.1016/j.devcel.2008.04.014. Review.


The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Lénárt P, Petronczki M, Steegmaier M, Di Fiore B, Lipp JJ, Hoffmann M, Rettig WJ, Kraut N, Peters JM.

Curr Biol. 2007 Feb 20;17(4):304-15. Epub 2007 Feb 8.


BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

Steegmaier M, Hoffmann M, Baum A, Lénárt P, Petronczki M, Krssák M, Gürtler U, Garin-Chesa P, Lieb S, Quant J, Grauert M, Adolf GR, Kraut N, Peters JM, Rettig WJ.

Curr Biol. 2007 Feb 20;17(4):316-22. Epub 2007 Feb 8.


In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1.

Lansing TJ, McConnell RT, Duckett DR, Spehar GM, Knick VB, Hassler DF, Noro N, Furuta M, Emmitte KA, Gilmer TM, Mook RA Jr, Cheung M.

Mol Cancer Ther. 2007 Feb;6(2):450-9. Epub 2007 Jan 31.


Polo-like kinase 3 is required for entry into S phase.

Zimmerman WC, Erikson RL.

Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1847-52. Epub 2007 Jan 30.


Mouse pre-replicative complex proteins colocalise and interact with the centrosome.

Stuermer A, Hoehn K, Faul T, Auth T, Brand N, Kneissl M, Pütter V, Grummt F.

Eur J Cell Biol. 2007 Jan;86(1):37-50. Epub 2006 Dec 6.


Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation.

Kang YH, Park JE, Yu LR, Soung NK, Yun SM, Bang JK, Seong YS, Yu H, Garfield S, Veenstra TD, Lee KS.

Mol Cell. 2006 Nov 3;24(3):409-22.


Polo-like kinases: a team in control of the division.

van de Weerdt BC, Medema RH.

Cell Cycle. 2006 Apr;5(8):853-64. Epub 2006 Apr 17. Review.


SAK/PLK4 is required for centriole duplication and flagella development.

Bettencourt-Dias M, Rodrigues-Martins A, Carpenter L, Riparbelli M, Lehmann L, Gatt MK, Carmo N, Balloux F, Callaini G, Glover DM.

Curr Biol. 2005 Dec 20;15(24):2199-207. Epub 2005 Dec 1.


Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting.

Hanisch A, Wehner A, Nigg EA, Silljé HH.

Mol Biol Cell. 2006 Jan;17(1):448-59. Epub 2005 Nov 2.


The Polo kinase Plk4 functions in centriole duplication.

Habedanck R, Stierhof YD, Wilkinson CJ, Nigg EA.

Nat Cell Biol. 2005 Nov;7(11):1140-6.


Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis.

Ko MA, Rosario CO, Hudson JW, Kulkarni S, Pollett A, Dennis JW, Swallow CJ.

Nat Genet. 2005 Aug;37(8):883-8. Epub 2005 Jul 17.


ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

Gumireddy K, Reddy MV, Cosenza SC, Boominathan R, Baker SJ, Papathi N, Jiang J, Holland J, Reddy EP.

Cancer Cell. 2005 Mar;7(3):275-86. Erratum in: Cancer Cell. 2005 May;7(5):497. Boomi Nathan, R [corrected to Boominathan, R].


Interaction of chromatin-associated Plk1 and Mcm7.

Tsvetkov L, Stern DF.

J Biol Chem. 2005 Mar 25;280(12):11943-7. Epub 2005 Jan 15.


Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells.

van Vugt MA, Brás A, Medema RH.

Mol Cell. 2004 Sep 10;15(5):799-811.


Polo-like kinase-2 is required for centriole duplication in mammalian cells.

Warnke S, Kemmler S, Hames RS, Tsai HL, Hoffmann-Rohrer U, Fry AM, Hoffmann I.

Curr Biol. 2004 Jul 13;14(13):1200-7.


Polo-like kinases and the orchestration of cell division.

Barr FA, Silljé HH, Nigg EA.

Nat Rev Mol Cell Biol. 2004 Jun;5(6):429-40. Review. No abstract available.


M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.

Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4419-24. Epub 2004 Mar 22.


The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.

Elia AE, Rellos P, Haire LF, Chao JW, Ivins FJ, Hoepker K, Mohammad D, Cantley LC, Smerdon SJ, Yaffe MB.

Cell. 2003 Oct 3;115(1):83-95.

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