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The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.

Cauchi S, Nead KT, Choquet H, Horber F, Potoczna N, Balkau B, Marre M, Charpentier G, Froguel P, Meyre D.

BMC Med Genet. 2008 May 22;9:45. doi: 10.1186/1471-2350-9-45.


Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease.

Menzaghi C, Trischitta V, Doria A.

Diabetes. 2007 May;56(5):1198-209. Review.


Comparison of anthropometric, area- and volume-based assessment of abdominal subcutaneous and visceral adipose tissue volumes using multi-detector computed tomography.

Maurovich-Horvat P, Massaro J, Fox CS, Moselewski F, O'Donnell CJ, Hoffmann U.

Int J Obes (Lond). 2007 Mar;31(3):500-6.


Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome.

Hara K, Horikoshi M, Yamauchi T, Yago H, Miyazaki O, Ebinuma H, Imai Y, Nagai R, Kadowaki T.

Diabetes Care. 2006 Jun;29(6):1357-62.


Adipose tissue: from lipid storage compartment to endocrine organ.

Scherer PE.

Diabetes. 2006 Jun;55(6):1537-45. Review.


ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity.

Bouatia-Naji N, Meyre D, Lobbens S, Séron K, Fumeron F, Balkau B, Heude B, Jouret B, Scherer PE, Dina C, Weill J, Froguel P.

Diabetes. 2006 Feb;55(2):545-50.


Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians.

Heid IM, Wagner SA, Gohlke H, Iglseder B, Mueller JC, Cip P, Ladurner G, Reiter R, Stadlmayr A, Mackevics V, Illig T, Kronenberg F, Paulweber B.

Diabetes. 2006 Feb;55(2):375-84.


Adiponectin polymorphisms, adiposity and insulin metabolism: HERITAGE family study and Oulu diabetic study.

Ukkola O, Santaniemi M, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bergman R, Kesäniemi YA, Bouchard C.

Ann Med. 2005;37(2):141-50.


Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity.

Vasseur F, Helbecque N, Lobbens S, Vasseur-Delannoy V, Dina C, Clément K, Boutin P, Kadowaki T, Scherer PE, Froguel P.

Diabetologia. 2005 May;48(5):892-9.


Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene.

Pollin TI, Tanner K, O'connell JR, Ott SH, Damcott CM, Shuldiner AR, McLenithan JC, Mitchell BD.

Diabetes. 2005 Jan;54(1):268-74.


The insulin gene variable number tandem repeat and risk of type 2 diabetes in a population-based sample of families and unrelated men and women.

Meigs JB, Dupuis J, Herbert AG, Liu C, Wilson PW, Cupples LA.

J Clin Endocrinol Metab. 2005 Feb;90(2):1137-43.


Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish caucasians.

Gu HF, Abulaiti A, Ostenson CG, Humphreys K, Wahlestedt C, Brookes AJ, Efendic S.

Diabetes. 2004 Feb;53 Suppl 1:S31-5.


Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.

Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, Hara K, Hada Y, Vasseur F, Froguel P, Kimura S, Nagai R, Kadowaki T.

J Biol Chem. 2003 Oct 10;278(41):40352-63.


Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians.

Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, Gaget S, Boutin P, Vaxillaire M, Leprêtre F, Dupont S, Hara K, Clément K, Bihain B, Kadowaki T, Froguel P.

Hum Mol Genet. 2002 Oct 1;11(21):2607-14.


Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p.

Mori Y, Otabe S, Dina C, Yasuda K, Populaire C, Lecoeur C, Vatin V, Durand E, Hara K, Okada T, Tobe K, Boutin P, Kadowaki T, Froguel P.

Diabetes. 2002 Apr;51(4):1247-55.


A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes.

Liu HX, Cartegni L, Zhang MQ, Krainer AR.

Nat Genet. 2001 Jan;27(1):55-8.


Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24.

Vionnet N, Hani EH, Dupont S, Gallina S, Francke S, Dotte S, De Matos F, Durand E, Leprêtre F, Lecoeur C, Gallina P, Zekiri L, Dina C, Froguel P.

Am J Hum Genet. 2000 Dec;67(6):1470-80.


Validation of the insulin sensitivity index (ISI(0,120)): comparison with other measures.

Gutt M, Davis CL, Spitzer SB, Llabre MM, Kumar M, Czarnecki EM, Schneiderman N, Skyler JS, Marks JB.

Diabetes Res Clin Pract. 2000 Mar;47(3):177-84.


Hyperinsulinemia, hyperglycemia, and impaired hemostasis: the Framingham Offspring Study.

Meigs JB, Mittleman MA, Nathan DM, Tofler GH, Singer DE, Murphy-Sheehy PM, Lipinska I, D'Agostino RB, Wilson PW.

JAMA. 2000 Jan 12;283(2):221-8.


Multipoint quantitative-trait linkage analysis in general pedigrees.

Almasy L, Blangero J.

Am J Hum Genet. 1998 May;62(5):1198-211.

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