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Items: 1 to 20 of 40

1.

Computational design of antibody-affinity improvement beyond in vivo maturation.

Lippow SM, Wittrup KD, Tidor B.

Nat Biotechnol. 2007 Oct;25(10):1171-6. Epub 2007 Sep 23.

2.

Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry.

Sami M, Rizkallah PJ, Dunn S, Molloy P, Moysey R, Vuidepot A, Baston E, Todorov P, Li Y, Gao F, Boulter JM, Jakobsen BK.

Protein Eng Des Sel. 2007 Aug;20(8):397-403. Epub 2007 Jul 20.

PMID:
17644531
3.

Integrating statistical pair potentials into protein complex prediction.

Mintseris J, Pierce B, Wiehe K, Anderson R, Chen R, Weng Z.

Proteins. 2007 Nov 15;69(3):511-20.

PMID:
17623839
4.

Structure-based protocol for identifying mutations that enhance protein-protein binding affinities.

Sammond DW, Eletr ZM, Purbeck C, Kimple RJ, Siderovski DP, Kuhlman B.

J Mol Biol. 2007 Aug 31;371(5):1392-404. Epub 2007 Jun 8.

5.

Trp/Met/Phe hot spots in protein-protein interactions: potential targets in drug design.

Ma B, Nussinov R.

Curr Top Med Chem. 2007;7(10):999-1005. Review.

PMID:
17508933
6.

Human TCR-binding affinity is governed by MHC class restriction.

Cole DK, Pumphrey NJ, Boulter JM, Sami M, Bell JI, Gostick E, Price DA, Gao GF, Sewell AK, Jakobsen BK.

J Immunol. 2007 May 1;178(9):5727-34.

7.

ZRANK: reranking protein docking predictions with an optimized energy function.

Pierce B, Weng Z.

Proteins. 2007 Jun 1;67(4):1078-86.

PMID:
17373710
8.

T cell receptor binding transition states and recognition of peptide/MHC.

Davis-Harrison RL, Insaidoo FK, Baker BM.

Biochemistry. 2007 Feb 20;46(7):1840-50. Epub 2007 Jan 24.

PMID:
17249694
9.

Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor.

Cole DK, Rizkallah PJ, Boulter JM, Sami M, Vuidepot AL, Glick M, Gao F, Bell JI, Jakobsen BK, Gao GF.

Proteins. 2007 Apr 1;67(1):65-74.

PMID:
17243170
10.

Harnessing phage and ribosome display for antibody optimisation.

Dufner P, Jermutus L, Minter RR.

Trends Biotechnol. 2006 Nov;24(11):523-9. Epub 2006 Sep 26. Review.

PMID:
17000017
11.

Computational design of a new hydrogen bond network and at least a 300-fold specificity switch at a protein-protein interface.

Joachimiak LA, Kortemme T, Stoddard BL, Baker D.

J Mol Biol. 2006 Aug 4;361(1):195-208. Epub 2006 May 24.

PMID:
16831445
12.

Long-range cooperative binding effects in a T cell receptor variable domain.

Moza B, Buonpane RA, Zhu P, Herfst CA, Rahman AK, McCormick JK, Kranz DM, Sundberg EJ.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9867-72. Epub 2006 Jun 20.

13.

Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.

Dunn SM, Rizkallah PJ, Baston E, Mahon T, Cameron B, Moysey R, Gao F, Sami M, Boulter J, Li Y, Jakobsen BK.

Protein Sci. 2006 Apr;15(4):710-21.

14.

Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design.

Clark LA, Boriack-Sjodin PA, Eldredge J, Fitch C, Friedman B, Hanf KJ, Jarpe M, Liparoto SF, Li Y, Lugovskoy A, Miller S, Rushe M, Sherman W, Simon K, Van Vlijmen H.

Protein Sci. 2006 May;15(5):949-60. Epub 2006 Apr 5.

15.

Rational design of intercellular adhesion molecule-1 (ICAM-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesion.

Song G, Lazar GA, Kortemme T, Shimaoka M, Desjarlais JR, Baker D, Springer TA.

J Biol Chem. 2006 Feb 24;281(8):5042-9. Epub 2005 Dec 14.

16.

Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.

Cho S, Swaminathan CP, Yang J, Kerzic MC, Guan R, Kieke MC, Kranz DM, Mariuzza RA, Sundberg EJ.

Structure. 2005 Dec;13(12):1775-87.

17.

Directed evolution of human T-cell receptors with picomolar affinities by phage display.

Li Y, Moysey R, Molloy PE, Vuidepot AL, Mahon T, Baston E, Dunn S, Liddy N, Jacob J, Jakobsen BK, Boulter JM.

Nat Biotechnol. 2005 Mar;23(3):349-54. Epub 2005 Feb 20.

PMID:
15723046
18.

High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3.

Chlewicki LK, Holler PD, Monti BC, Clutter MR, Kranz DM.

J Mol Biol. 2005 Feb 11;346(1):223-39. Epub 2004 Dec 22.

PMID:
15663940
19.

The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition.

Borg NA, Ely LK, Beddoe T, Macdonald WA, Reid HH, Clements CS, Purcell AW, Kjer-Nielsen L, Miles JJ, Burrows SR, McCluskey J, Rossjohn J.

Nat Immunol. 2005 Feb;6(2):171-80. Epub 2005 Jan 9.

PMID:
15640805
20.

Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition.

Laugel B, Boulter JM, Lissin N, Vuidepot A, Li Y, Gostick E, Crotty LE, Douek DC, Hemelaar J, Price DA, Jakobsen BK, Sewell AK.

J Biol Chem. 2005 Jan 21;280(3):1882-92. Epub 2004 Nov 4.

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