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Items: 19

1.

Microfluidics for drug discovery and development: from target selection to product lifecycle management.

Kang L, Chung BG, Langer R, Khademhosseini A.

Drug Discov Today. 2008 Jan;13(1-2):1-13. doi: 10.1016/j.drudis.2007.10.003. Epub 2007 Nov 26. Review.

2.

Tools for efficient high-throughput synthesis.

Chighine A, Sechi G, Bradley M.

Drug Discov Today. 2007 Jun;12(11-12):459-64. Epub 2007 Apr 26. Review.

PMID:
17532530
3.

Oligosaccharide synthesis in microreactors.

Carrel FR, Geyer K, Codée JD, Seeberger PH.

Org Lett. 2007 Jun 7;9(12):2285-8. Epub 2007 May 10.

PMID:
17489597
4.

Greener approaches to organic synthesis using microreactor technology.

Mason BP, Price KE, Steinbacher JL, Bogdan AR, McQuade DT.

Chem Rev. 2007 Jun;107(6):2300-18. Epub 2007 Mar 21. Review. No abstract available.

PMID:
17373852
5.

Recent advances in synthetic micro reaction technology.

Watts P, Wiles C.

Chem Commun (Camb). 2007 Feb 7;(5):443-67. Epub 2006 Oct 12.

PMID:
17252096
6.

Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles.

Baumann M, Baxendale IR, Ley SV, Smith CD, Tranmer GK.

Org Lett. 2006 Nov 9;8(23):5231-4.

PMID:
17078685
7.

Microreactors as tools for synthetic chemists-the chemists' round-bottomed flask of the 21st century?

Geyer K, Codée JD, Seeberger PH.

Chemistry. 2006 Nov 15;12(33):8434-42.

PMID:
16991184
8.

A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly.

Baxendale IR, Deeley J, Griffiths-Jones CM, Ley SV, Saaby S, Tranmer GK.

Chem Commun (Camb). 2006 Jun 28;(24):2566-8. Epub 2006 Mar 24.

PMID:
16779479
9.

Knowledge-based design of target-focused libraries using protein-ligand interaction constraints.

Deng Z, Chuaqui C, Singh J.

J Med Chem. 2006 Jan 26;49(2):490-500.

PMID:
16420036
10.

Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3.

Li Z, Chen W, Hale JJ, Lynch CL, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Chrebet G, Parent SA, Bergstrom J, Card D, Forrest M, Quackenbush EJ, Wickham LA, Vargas H, Evans RM, Rosen H, Mandala S.

J Med Chem. 2005 Oct 6;48(20):6169-73.

PMID:
16190743
11.

Discovery and structure-activity relationship of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers and potential anticancer agents.

Zhang HZ, Kasibhatla S, Kuemmerle J, Kemnitzer W, Ollis-Mason K, Qiu L, Crogan-Grundy C, Tseng B, Drewe J, Cai SX.

J Med Chem. 2005 Aug 11;48(16):5215-23.

PMID:
16078840
12.

Room-temperature Swern oxidations by using a microscale flow system.

Kawaguchi T, Miyata H, Ataka K, Mae K, Yoshida J.

Angew Chem Int Ed Engl. 2005 Apr 15;44(16):2413-6. No abstract available.

PMID:
15761899
13.

Rapid and efficient synthesis of 1,2,4-oxadiazoles utilizing polymer-supported reagents under microwave heating.

Wang Y, Miller RL, Sauer DR, Djuric SW.

Org Lett. 2005 Mar 3;7(5):925-8.

PMID:
15727476
14.

Navigating chemical space for biology and medicine.

Lipinski C, Hopkins A.

Nature. 2004 Dec 16;432(7019):855-61. Review.

PMID:
15602551
15.

Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.

Roppe J, Smith ND, Huang D, Tehrani L, Wang B, Anderson J, Brodkin J, Chung J, Jiang X, King C, Munoz B, Varney MA, Prasit P, Cosford ND.

J Med Chem. 2004 Sep 9;47(19):4645-8.

PMID:
15341479
16.

Synthesis and analysis of combinatorial libraries performed in an automated micro reactor system.

Garcia-Egido E, Spikmans V, Wong SY, Warrington BH.

Lab Chip. 2003 May;3(2):73-6. Epub 2003 Apr 24.

PMID:
15100785
17.

Design, synthesis, and evaluation of Phe-Gly mimetics: heterocyclic building blocks for pseudopeptides.

Borg S, Vollinga RC, Labarre M, Payza K, Terenius L, Luthman K.

J Med Chem. 1999 Oct 21;42(21):4331-42.

PMID:
10543877
18.

Oxadiazoles as ester bioisosteric replacements in compounds related to disoxaril. Antirhinovirus activity.

Diana GD, Volkots DL, Nitz TJ, Bailey TR, Long MA, Vescio N, Aldous S, Pevear DC, Dutko FJ.

J Med Chem. 1994 Jul 22;37(15):2421-36.

PMID:
8057290
19.

[Studies of pyrazine derivatives. XX. Synthesis and tuberculostatic activity of 3-pyrazinol-1,2,4-oxadiazole derivatives].

Pancechowska-Ksepko D, Foks H, Janowiec M, Zwolska-Kwiek Z.

Acta Pol Pharm. 1986;43(3):211-7. Polish. No abstract available.

PMID:
3098054

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