References for this PMC Article for PMID: 18596031

Year	Number of Results
1982	1
1988	1
1989	2
1990	1
1991	1
1992	1
1993	1
1994	2
1995	1
1996	4
1998	5
1999	3
2000	5
2001	5
2002	3
2003	4
2004	4
2005	1
2006	6
2007	7
2008	3
2024	0

1

NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform.

Toyoda E, Kagaya S, Cowell IG, Kurosawa A, Kamoshita K, Nishikawa K, Iiizumi S, Koyama H, Austin CA, Adachi N. Toyoda E, et al. J Biol Chem. 2008 Aug 29;283(35):23711-20. doi: 10.1074/jbc.M803936200. Epub 2008 Jul 2. J Biol Chem. 2008. PMID: 18596031 Free PMC article.

2

Structural basis for gate-DNA recognition and bending by type IIA topoisomerases.

Dong KC, Berger JM. Dong KC, et al. Nature. 2007 Dec 20;450(7173):1201-5. doi: 10.1038/nature06396. Nature. 2007. PMID: 18097402

3

The mechanism of human nonhomologous DNA end joining.

Lieber MR. Lieber MR. J Biol Chem. 2008 Jan 4;283(1):1-5. doi: 10.1074/jbc.R700039200. Epub 2007 Nov 12. J Biol Chem. 2008. PMID: 17999957 Free article. Review.

4

NK314, a novel topoisomerase II inhibitor, induces rapid DNA double-strand breaks and exhibits superior antitumor effects against tumors resistant to other topoisomerase II inhibitors.

Onda T, Toyoda E, Miyazaki O, Seno C, Kagaya S, Okamoto K, Nishikawa K. Onda T, et al. Cancer Lett. 2008 Jan 18;259(1):99-110. doi: 10.1016/j.canlet.2007.10.004. Epub 2007 Nov 12. Cancer Lett. 2008. PMID: 17998154

5

Absence of p53 enhances growth defects and etoposide sensitivity of human cells lacking the Bloom syndrome helicase BLM.

So S, Adachi N, Koyama H. So S, et al. DNA Cell Biol. 2007 Jul;26(7):517-25. doi: 10.1089/dna.2007.0578. DNA Cell Biol. 2007. PMID: 17630856

6

Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

Azarova AM, Lyu YL, Lin CP, Tsai YC, Lau JY, Wang JC, Liu LF. Azarova AM, et al. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11014-9. doi: 10.1073/pnas.0704002104. Epub 2007 Jun 19. Proc Natl Acad Sci U S A. 2007. PMID: 17578914 Free PMC article.

7

C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo.

Linka RM, Porter AC, Volkov A, Mielke C, Boege F, Christensen MO. Linka RM, et al. Nucleic Acids Res. 2007;35(11):3810-22. doi: 10.1093/nar/gkm102. Epub 2007 May 25. Nucleic Acids Res. 2007. PMID: 17526531 Free PMC article.

8

Inhibition of topoisomerase IIalpha and G2 cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials.

Guo L, Liu X, Nishikawa K, Plunkett W. Guo L, et al. Mol Cancer Ther. 2007 May;6(5):1501-8. doi: 10.1158/1535-7163.MCT-06-0780. Mol Cancer Ther. 2007. PMID: 17513599

9

Simple one-week method to construct gene-targeting vectors: application to production of human knockout cell lines.

Iiizumi S, Nomura Y, So S, Uegaki K, Aoki K, Shibahara K, Adachi N, Koyama H. Iiizumi S, et al. Biotechniques. 2006 Sep;41(3):311-6. doi: 10.2144/000112233. Biotechniques. 2006. PMID: 16989091 Free article.

10

Rad54: the Swiss Army knife of homologous recombination?

Heyer WD, Li X, Rolfsmeier M, Zhang XP. Heyer WD, et al. Nucleic Acids Res. 2006;34(15):4115-25. doi: 10.1093/nar/gkl481. Epub 2006 Aug 25. Nucleic Acids Res. 2006. PMID: 16935872 Free PMC article. Review.

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