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Items: 1 to 20 of 30

1.

Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization.

Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ.

J Neurosci. 2008 Apr 16;28(16):4231-7. doi: 10.1523/JNEUROSCI.5161-07.2008.

2.

Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice.

Martins IC, Kuperstein I, Wilkinson H, Maes E, Vanbrabant M, Jonckheere W, Van Gelder P, Hartmann D, D'Hooge R, De Strooper B, Schymkowitz J, Rousseau F.

EMBO J. 2008 Jan 9;27(1):224-33. Epub 2007 Dec 6.

3.

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway.

Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL.

J Neurosci. 2007 Mar 14;27(11):2866-75.

4.

Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning.

O'Sullivan NC, McGettigan PA, Sheridan GK, Pickering M, Conboy L, O'Connor JJ, Moynagh PN, Higgins DG, Regan CM, Murphy KJ.

J Neurochem. 2007 May;101(4):1085-98. Epub 2007 Feb 9.

5.

Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease.

Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL, Klein WL.

J Neurosci. 2007 Jan 24;27(4):796-807.

6.

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss.

Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R.

Neuron. 2006 Dec 7;52(5):831-43.

7.

A specific amyloid-beta protein assembly in the brain impairs memory.

Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH.

Nature. 2006 Mar 16;440(7082):352-7.

PMID:
16541076
8.

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2.

Tavazoie SF, Alvarez VA, Ridenour DA, Kwiatkowski DJ, Sabatini BL.

Nat Neurosci. 2005 Dec;8(12):1727-34. Epub 2005 Nov 6.

PMID:
16286931
9.

Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy.

Spires TL, Meyer-Luehmann M, Stern EA, McLean PJ, Skoch J, Nguyen PT, Bacskai BJ, Hyman BT.

J Neurosci. 2005 Aug 3;25(31):7278-87.

10.

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ.

J Neurosci. 2005 Mar 9;25(10):2455-62. Erratum in: J Neurosci. 2005 May 4;25(18):4658.

11.
12.

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function.

Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH.

Nat Neurosci. 2005 Jan;8(1):79-84. Epub 2004 Dec 19.

PMID:
15608634
13.

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.

Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ.

Nature. 2002 Apr 4;416(6880):535-9.

PMID:
11932745
14.

Long-term depression: a cascade of induction and expression mechanisms.

Kemp N, Bashir ZI.

Prog Neurobiol. 2001 Nov;65(4):339-65. Review.

PMID:
11527572
15.

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW.

Nature. 2000 Dec 21-28;408(6815):982-5. Erratum in: Nature 2001 Aug 9;412(6847):660.

PMID:
11140686
16.

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain.

Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ.

Biochemistry. 2000 Sep 5;39(35):10831-9.

PMID:
10978169
17.

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.

Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L.

J Neurosci. 2000 Jun 1;20(11):4050-8.

18.

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease.

McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ, Beyreuther K, Bush AI, Masters CL.

Ann Neurol. 1999 Dec;46(6):860-6.

PMID:
10589538
19.

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease.

Lue LF, Kuo YM, Roher AE, Brachova L, Shen Y, Sue L, Beach T, Kurth JH, Rydel RE, Rogers J.

Am J Pathol. 1999 Sep;155(3):853-62.

20.

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.

Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, Klein WL.

Proc Natl Acad Sci U S A. 1998 May 26;95(11):6448-53.

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