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Items: 1 to 20 of 44

1.

Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.

Thomas EK, Cancelas JA, Chae HD, Cox AD, Keller PJ, Perrotti D, Neviani P, Druker BJ, Setchell KD, Zheng Y, Harris CE, Williams DA.

Cancer Cell. 2007 Nov;12(5):467-78.

2.

MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment.

Stubbs MC, Kim YM, Krivtsov AV, Wright RD, Feng Z, Agarwal J, Kung AL, Armstrong SA.

Leukemia. 2008 Jan;22(1):66-77. Epub 2007 Sep 13.

3.

FLT3 as a therapeutic target in childhood acute leukemia.

Stubbs MC, Armstrong SA.

Curr Drug Targets. 2007 Jun;8(6):703-14. Review.

PMID:
17584026
4.

Modeling the initiation and progression of human acute leukemia in mice.

Barabé F, Kennedy JA, Hope KJ, Dick JE.

Science. 2007 Apr 27;316(5824):600-4.

5.

The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages.

Iwasaki H, Mizuno S, Arinobu Y, Ozawa H, Mori Y, Shigematsu H, Takatsu K, Tenen DG, Akashi K.

Genes Dev. 2006 Nov 1;20(21):3010-21.

6.
7.

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J, Levine JE, Wang J, Hahn WC, Gilliland DG, Golub TR, Armstrong SA.

Nature. 2006 Aug 17;442(7104):818-22. Epub 2006 Jul 16.

PMID:
16862118
8.
9.

Telomerase regulation and stem cell behaviour.

Flores I, Benetti R, Blasco MA.

Curr Opin Cell Biol. 2006 Jun;18(3):254-60. Epub 2006 Apr 17. Review.

PMID:
16617011
10.

A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy.

Chen W, Li Q, Hudson WA, Kumar A, Kirchhof N, Kersey JH.

Blood. 2006 Jul 15;108(2):669-77. Epub 2006 Mar 21.

11.

Low or absent SPARC expression in acute myeloid leukemia with MLL rearrangements is associated with sensitivity to growth inhibition by exogenous SPARC protein.

DiMartino JF, Lacayo NJ, Varadi M, Li L, Saraiya C, Ravindranath Y, Yu R, Sikic BI, Raimondi SC, Dahl GV.

Leukemia. 2006 Mar;20(3):426-32.

PMID:
16424866
12.

The MLL gene and translocations involving chromosomal band 11q23 in acute leukemia.

De Braekeleer M, Morel F, Le Bris MJ, Herry A, Douet-Guilbert N.

Anticancer Res. 2005 May-Jun;25(3B):1931-44. Review.

13.

Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells.

Warner JK, Wang JC, Takenaka K, Doulatov S, McKenzie JL, Harrington L, Dick JE.

Leukemia. 2005 Oct;19(10):1794-805.

PMID:
16094415
14.

Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization.

Cancelas JA, Lee AW, Prabhakar R, Stringer KF, Zheng Y, Williams DA.

Nat Med. 2005 Aug;11(8):886-91. Epub 2005 Jul 17.

PMID:
16025125
15.

Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia.

Stam RW, den Boer ML, Schneider P, Nollau P, Horstmann M, Beverloo HB, van der Voort E, Valsecchi MG, de Lorenzo P, Sallan SE, Armstrong SA, Pieters R.

Blood. 2005 Oct 1;106(7):2484-90. Epub 2005 Jun 14.

16.

Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes.

Lacayo NJ, Meshinchi S, Kinnunen P, Yu R, Wang Y, Stuber CM, Douglas L, Wahab R, Becton DL, Weinstein H, Chang MN, Willman CL, Radich JP, Tibshirani R, Ravindranath Y, Sikic BI, Dahl GV.

Blood. 2004 Nov 1;104(9):2646-54. Epub 2004 Jul 13.

17.

Gene expression profiling of pediatric acute myelogenous leukemia.

Ross ME, Mahfouz R, Onciu M, Liu HC, Zhou X, Song G, Shurtleff SA, Pounds S, Cheng C, Ma J, Ribeiro RC, Rubnitz JE, Girtman K, Williams WK, Raimondi SC, Liang DC, Shih LY, Pui CH, Downing JR.

Blood. 2004 Dec 1;104(12):3679-87. Epub 2004 Jun 29.

18.

Stepwise reprogramming of B cells into macrophages.

Xie H, Ye M, Feng R, Graf T.

Cell. 2004 May 28;117(5):663-76.

19.

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.

Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y.

Proc Natl Acad Sci U S A. 2004 May 18;101(20):7618-23. Epub 2004 May 5.

20.

Prognostically useful gene-expression profiles in acute myeloid leukemia.

Valk PJ, Verhaak RG, Beijen MA, Erpelinck CA, Barjesteh van Waalwijk van Doorn-Khosrovani S, Boer JM, Beverloo HB, Moorhouse MJ, van der Spek PJ, Löwenberg B, Delwel R.

N Engl J Med. 2004 Apr 15;350(16):1617-28.

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