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Items: 1 to 20 of 61

1.

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma.

Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C.

Immunity. 2008 Jan;28(1):29-39. doi: 10.1016/j.immuni.2007.11.016. Epub 2007 Dec 27.

2.

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells.

Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C.

Nature. 2007 Jul 26;448(7152):480-3. Epub 2007 Jun 20.

PMID:
17581589
3.

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.

Korn T, Bettelli E, Gao W, Awasthi A, Jäger A, Strom TB, Oukka M, Kuchroo VK.

Nature. 2007 Jul 26;448(7152):484-487. doi: 10.1038/nature05970. Epub 2007 Jun 20.

4.

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.

Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR.

Nat Immunol. 2007 Sep;8(9):967-74. Epub 2007 Jun 20.

PMID:
17581537
5.

Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.

Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H.

Science. 2007 Jul 13;317(5835):256-60. Epub 2007 Jun 14.

7.

Stat3 and Stat4 direct development of IL-17-secreting Th cells.

Mathur AN, Chang HC, Zisoulis DG, Stritesky GL, Yu Q, O'Malley JT, Kapur R, Levy DE, Kansas GS, Kaplan MH.

J Immunol. 2007 Apr 15;178(8):4901-7.

8.

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen TR, Bäckström BT, Sobel RA, Wucherpfennig KW, Strom TB, Oukka M, Kuchroo VK.

Nat Med. 2007 Apr;13(4):423-31. Epub 2007 Mar 25.

9.

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.

Laurence A, Tato CM, Davidson TS, Kanno Y, Chen Z, Yao Z, Blank RB, Meylan F, Siegel R, Hennighausen L, Shevach EM, O'shea JJ.

Immunity. 2007 Mar;26(3):371-81.

10.

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge.

Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, Shen F, Eaton SM, Gaffen SL, Swain SL, Locksley RM, Haynes L, Randall TD, Cooper AM.

Nat Immunol. 2007 Apr;8(4):369-77. Epub 2007 Mar 11.

PMID:
17351619
11.

A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage.

Steinman L.

Nat Med. 2007 Feb;13(2):139-45. Review. Erratum in: Nat Med. 2007 Mar;13(3):385.

PMID:
17290272
12.

STAT3 regulates cytokine-mediated generation of inflammatory helper T cells.

Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, Dong C.

J Biol Chem. 2007 Mar 30;282(13):9358-63. Epub 2007 Feb 3.

13.

IL-25 regulates Th17 function in autoimmune inflammation.

Kleinschek MA, Owyang AM, Joyce-Shaikh B, Langrish CL, Chen Y, Gorman DM, Blumenschein WM, McClanahan T, Brombacher F, Hurst SD, Kastelein RA, Cua DJ.

J Exp Med. 2007 Jan 22;204(1):161-70. Epub 2007 Jan 2.

14.

Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease.

Veldhoen M, Hocking RJ, Flavell RA, Stockinger B.

Nat Immunol. 2006 Nov;7(11):1151-6. Epub 2006 Sep 24.

PMID:
16998492
15.

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.

Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, Littman DR.

Cell. 2006 Sep 22;126(6):1121-33.

16.

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells.

Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N.

Nat Immunol. 2006 Sep;7(9):929-36. Epub 2006 Aug 13.

PMID:
16906167
17.

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.

Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, Johnson LM, Villarino AV, Huang Q, Yoshimura A, Sehy D, Saris CJ, O'Shea JJ, Hennighausen L, Ernst M, Hunter CA.

Nat Immunol. 2006 Sep;7(9):937-45. Epub 2006 Aug 13.

PMID:
16906166
18.

Interleukin 18-independent engagement of interleukin 18 receptor-alpha is required for autoimmune inflammation.

Gutcher I, Urich E, Wolter K, Prinz M, Becher B.

Nat Immunol. 2006 Sep;7(9):946-53. Epub 2006 Aug 13.

19.

T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17.

Rangachari M, Mauermann N, Marty RR, Dirnhofer S, Kurrer MO, Komnenovic V, Penninger JM, Eriksson U.

J Exp Med. 2006 Aug 7;203(8):2009-19. Epub 2006 Jul 31.

20.

T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.

Mathur AN, Chang HC, Zisoulis DG, Kapur R, Belladonna ML, Kansas GS, Kaplan MH.

Blood. 2006 Sep 1;108(5):1595-601. Epub 2006 May 2.

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