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AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.

Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ.

J Clin Invest. 2007 Aug;117(8):2325-36.


Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling.

Münzberg H, Jobst EE, Bates SH, Jones J, Villanueva E, Leshan R, Björnholm M, Elmquist J, Sleeman M, Cowley MA, Myers MG Jr.

J Neurosci. 2007 Jan 3;27(1):69-74.


Rapid inhibition of neurons in the dorsal motor nucleus of the vagus by leptin.

Williams KW, Zsombok A, Smith BN.

Endocrinology. 2007 Apr;148(4):1868-81. Epub 2006 Dec 28.


Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.

Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, Kahn CR.

Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12093-7. Epub 2006 Jul 31. Erratum in: Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3588.


Serotonin reciprocally regulates melanocortin neurons to modulate food intake.

Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA.

Neuron. 2006 Jul 20;51(2):239-49.


Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC.

J Clin Invest. 2006 Jul;116(7):1886-901. Epub 2006 Jun 22.


Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis.

Kim MS, Pak YK, Jang PG, Namkoong C, Choi YS, Won JC, Kim KS, Kim SW, Kim HS, Park JY, Kim YB, Lee KU.

Nat Neurosci. 2006 Jul;9(7):901-6. Epub 2006 Jun 18.


Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia.

Luo J, Sobkiw CL, Hirshman MF, Logsdon MN, Li TQ, Goodyear LJ, Cantley LC.

Cell Metab. 2006 May;3(5):355-66.


Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways.

Bookout AL, Mangelsdorf DJ.

Nucl Recept Signal. 2003;1:e012. Epub 2003 Dec 23.


Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake.

Kitamura T, Feng Y, Kitamura YI, Chua SC Jr, Xu AW, Barsh GS, Rossetti L, Accili D.

Nat Med. 2006 May;12(5):534-40. Epub 2006 Apr 9.


Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis.

Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S Jr, Elmquist JK, Lowell BB.

Neuron. 2006 Jan 19;49(2):191-203.


Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.

Morton GJ, Gelling RW, Niswender KD, Morrison CD, Rhodes CJ, Schwartz MW.

Cell Metab. 2005 Dec;2(6):411-20.


Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.

Luo J, McMullen JR, Sobkiw CL, Zhang L, Dorfman AL, Sherwood MC, Logsdon MN, Horner JW, DePinho RA, Izumo S, Cantley LC.

Mol Cell Biol. 2005 Nov;25(21):9491-502.


The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer.

Luo J, Cantley LC.

Cell Cycle. 2005 Oct;4(10):1309-12. Epub 2005 Oct 28.


MAO A knockout attenuates adrenocortical response to various kinds of stress.

Popova NK, Maslova LN, Morosova EA, Bulygina VV, Seif I.

Psychoneuroendocrinology. 2006 Feb;31(2):179-86. Epub 2005 Aug 19. Erratum in: Psychoneuroendocrinology. 2006 Sep;31(8):1027.


Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling.

Morrison CD, Morton GJ, Niswender KD, Gelling RW, Schwartz MW.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1051-7. Epub 2005 Jul 26.


The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex.

Luo J, Field SJ, Lee JY, Engelman JA, Cantley LC.

J Cell Biol. 2005 Aug 1;170(3):455-64. Epub 2005 Jul 25.

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