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BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes.

Yang X, Lee PJ, Long L, Trembath RC, Morrell NW.

Am J Respir Cell Mol Biol. 2007 Nov;37(5):598-605. Epub 2007 Jun 28.


Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation.

Hansmann G, Wagner RA, Schellong S, Perez VA, Urashima T, Wang L, Sheikh AY, Suen RS, Stewart DJ, Rabinovitch M.

Circulation. 2007 Mar 13;115(10):1275-84. Epub 2007 Mar 5.


Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma.

Burgermeister E, Chuderland D, Hanoch T, Meyer M, Liscovitch M, Seger R.

Mol Cell Biol. 2007 Feb;27(3):803-17. Epub 2006 Nov 13.


Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells.

Ogawa D, Nomiyama T, Nakamachi T, Heywood EB, Stone JF, Berger JP, Law RE, Bruemmer D.

Circ Res. 2006 Apr 14;98(7):e50-9. Epub 2006 Mar 23.


Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease.

Risner ME, Saunders AM, Altman JF, Ormandy GC, Craft S, Foley IM, Zvartau-Hind ME, Hosford DA, Roses AD; Rosiglitazone in Alzheimer's Disease Study Group.

Pharmacogenomics J. 2006 Jul-Aug;6(4):246-54. Epub 2006 Jan 31.


Reversal of experimental pulmonary hypertension by PDGF inhibition.

Schermuly RT, Dony E, Ghofrani HA, Pullamsetti S, Savai R, Roth M, Sydykov A, Lai YJ, Weissmann N, Seeger W, Grimminger F.

J Clin Invest. 2005 Oct;115(10):2811-21.


Imatinib for the treatment of pulmonary arterial hypertension.

Ghofrani HA, Seeger W, Grimminger F.

N Engl J Med. 2005 Sep 29;353(13):1412-3. No abstract available.


PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1.

Benkirane K, Amiri F, Diep QN, El Mabrouk M, Schiffrin EL.

Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H390-7. Epub 2005 Sep 9.


Pioglitazone lowers systemic asymmetric dimethylarginine by inducing dimethylarginine dimethylaminohydrolase in rats.

Wakino S, Hayashi K, Tatematsu S, Hasegawa K, Takamatsu I, Kanda T, Homma K, Yoshioka K, Sugano N, Saruta T.

Hypertens Res. 2005 Mar;28(3):255-62.


Platelet-derived growth factor receptor-beta (PDGFR-beta) activation promotes its association with the low density lipoprotein receptor-related protein (LRP). Evidence for co-receptor function.

Newton CS, Loukinova E, Mikhailenko I, Ranganathan S, Gao Y, Haudenschild C, Strickland DK.

J Biol Chem. 2005 Jul 29;280(30):27872-8. Epub 2005 Jun 8.


Asymmetrical dimethylarginine in idiopathic pulmonary arterial hypertension.

Kielstein JT, Bode-Böger SM, Hesse G, Martens-Lobenhoffer J, Takacs A, Fliser D, Hoeper MM.

Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1414-8. Epub 2005 Apr 28.


Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo.

Shurin GV, Ferris RL, Tourkova IL, Perez L, Lokshin A, Balkir L, Collins B, Chatta GS, Shurin MR.

J Immunol. 2005 May 1;174(9):5490-8. Erratum in: J Immunol. 2006 Mar 15;176(6):3840. Ferris, Robert [corrected to Ferris, Robert L].


Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells. Only phosphatidylinositol 3'-kinase is important.

Vantler M, Caglayan E, Zimmermann WH, Bäumer AT, Rosenkranz S.

J Biol Chem. 2005 Apr 8;280(14):14168-76. Epub 2005 Jan 7.


BMPR2 mutations in pulmonary arterial hypertension with congenital heart disease.

Roberts KE, McElroy JJ, Wong WP, Yen E, Widlitz A, Barst RJ, Knowles JA, Morse JH.

Eur Respir J. 2004 Sep;24(3):371-4.


Divergent effects of peroxisome proliferator-activated receptor gamma agonists and tumor necrosis factor alpha on adipocyte ApoE expression.

Yue L, Rasouli N, Ranganathan G, Kern PA, Mazzone T.

J Biol Chem. 2004 Nov 12;279(46):47626-32. Epub 2004 Aug 31.


Genetic basis of pulmonary arterial hypertension: current understanding and future directions.

Newman JH, Trembath RC, Morse JA, Grunig E, Loyd JE, Adnot S, Coccolo F, Ventura C, Phillips JA 3rd, Knowles JA, Janssen B, Eickelberg O, Eddahibi S, Herve P, Nichols WC, Elliott G.

J Am Coll Cardiol. 2004 Jun 16;43(12 Suppl S):33S-39S. Review.


Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells.

Marx N, Duez H, Fruchart JC, Staels B.

Circ Res. 2004 May 14;94(9):1168-78. Review.


Imatinib attenuates diabetes-associated atherosclerosis.

Lassila M, Allen TJ, Cao Z, Thallas V, Jandeleit-Dahm KA, Candido R, Cooper ME.

Arterioscler Thromb Vasc Biol. 2004 May;24(5):935-42. Epub 2004 Feb 26.


Muscle-specific Pparg deletion causes insulin resistance.

Hevener AL, He W, Barak Y, Le J, Bandyopadhyay G, Olson P, Wilkes J, Evans RM, Olefsky J.

Nat Med. 2003 Dec;9(12):1491-7. Epub 2003 Nov 16.


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