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Items: 1 to 20 of 44


A role for the IkappaB family member Bcl-3 in the control of central immunologic tolerance.

Zhang X, Wang H, Claudio E, Brown K, Siebenlist U.

Immunity. 2007 Sep;27(3):438-52.


Negative regulation of toll-like receptor signaling by NF-kappaB p50 ubiquitination blockade.

Carmody RJ, Ruan Q, Palmer S, Hilliard B, Chen YH.

Science. 2007 Aug 3;317(5838):675-8.


Unravelling the pathogenesis of inflammatory bowel disease.

Xavier RJ, Podolsky DK.

Nature. 2007 Jul 26;448(7152):427-34. Review.


Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice.

Elson CO, Cong Y, Weaver CT, Schoeb TR, McClanahan TK, Fick RB, Kastelein RA.

Gastroenterology. 2007 Jun;132(7):2359-70. Epub 2007 Apr 13.


Gnotobiotic IL-10-/-;NF-kappa B(EGFP) mice reveal the critical role of TLR/NF-kappa B signaling in commensal bacteria-induced colitis.

Karrasch T, Kim JS, Muhlbauer M, Magness ST, Jobin C.

J Immunol. 2007 May 15;178(10):6522-32.


Essential roles of c-Rel in TLR-induced IL-23 p19 gene expression in dendritic cells.

Carmody RJ, Ruan Q, Liou HC, Chen YH.

J Immunol. 2007 Jan 1;178(1):186-91.


General nature of the STAT3-activated anti-inflammatory response.

El Kasmi KC, Holst J, Coffre M, Mielke L, de Pauw A, Lhocine N, Smith AM, Rutschman R, Kaushal D, Shen Y, Suda T, Donnelly RP, Myers MG Jr, Alexander W, Vignali DA, Watowich SS, Ernst M, Hilton DJ, Murray PJ.

J Immunol. 2006 Dec 1;177(11):7880-8.


IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor of cytokine signaling-3.

Qin H, Wilson CA, Roberts KL, Baker BJ, Zhao X, Benveniste EN.

J Immunol. 2006 Dec 1;177(11):7761-71.


A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.

Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH.

Science. 2006 Dec 1;314(5804):1461-3. Epub 2006 Oct 26.


Interleukin-23 drives innate and T cell-mediated intestinal inflammation.

Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, Powrie F, Maloy KJ.

J Exp Med. 2006 Oct 30;203(11):2473-83. Epub 2006 Oct 9.


Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis.

Becker C, Dornhoff H, Neufert C, Fantini MC, Wirtz S, Huebner S, Nikolaev A, Lehr HA, Murphy AJ, Valenzuela DM, Yancopoulos GD, Galle PR, Karow M, Neurath MF.

J Immunol. 2006 Sep 1;177(5):2760-4.


Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

Uhlig HH, McKenzie BS, Hue S, Thompson C, Joyce-Shaikh B, Stepankova R, Robinson N, Buonocore S, Tlaskalova-Hogenova H, Cua DJ, Powrie F.

Immunity. 2006 Aug;25(2):309-18.


Role of toll-like receptors in spontaneous commensal-dependent colitis.

Rakoff-Nahoum S, Hao L, Medzhitov R.

Immunity. 2006 Aug;25(2):319-29. Epub 2006 Aug 3.


Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis.

Sartor RB.

Nat Clin Pract Gastroenterol Hepatol. 2006 Jul;3(7):390-407. Review.


IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.

Yen D, Cheung J, Scheerens H, Poulet F, McClanahan T, McKenzie B, Kleinschek MA, Owyang A, Mattson J, Blumenschein W, Murphy E, Sathe M, Cua DJ, Kastelein RA, Rennick D.

J Clin Invest. 2006 May;116(5):1310-6.


Signalling pathways and molecular interactions of NOD1 and NOD2.

Strober W, Murray PJ, Kitani A, Watanabe T.

Nat Rev Immunol. 2006 Jan;6(1):9-20. Review.


Divergent mechanisms utilized by SOCS3 to mediate interleukin-10 inhibition of tumor necrosis factor alpha and nitric oxide production by macrophages.

Qasimi P, Ming-Lum A, Ghanipour A, Ong CJ, Cox ME, Ihle J, Cacalano N, Yoshimura A, Mui AL.

J Biol Chem. 2006 Mar 10;281(10):6316-24. Epub 2005 Dec 12.


Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria.

Kamada N, Hisamatsu T, Okamoto S, Sato T, Matsuoka K, Arai K, Nakai T, Hasegawa A, Inoue N, Watanabe N, Akagawa KS, Hibi T.

J Immunol. 2005 Nov 15;175(10):6900-8.


The IkappaB protein Bcl-3 negatively regulates transcription of the IL-10 gene in macrophages.

Riemann M, Endres R, Liptay S, Pfeffer K, Schmid RM.

J Immunol. 2005 Sep 15;175(6):3560-8.


The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription.

Murray PJ.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8686-91. Epub 2005 Jun 3.

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