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Items: 1 to 20 of 29

1.

Thymidyl biosynthesis enzymes as antibiotic targets.

Chernyshev A, Fleischmann T, Kohen A.

Appl Microbiol Biotechnol. 2007 Feb;74(2):282-9. Epub 2007 Jan 11. Review.

PMID:
17216455
2.
3.

Catalytic mechanism and structure of viral flavin-dependent thymidylate synthase ThyX.

Graziani S, Bernauer J, Skouloubris S, Graille M, Zhou CZ, Marchand C, Decottignies P, van Tilbeurgh H, Myllykallio H, Liebl U.

J Biol Chem. 2006 Aug 18;281(33):24048-57. Epub 2006 May 17.

4.

Thymidylate synthase pharmacogenetics.

Marsh S.

Invest New Drugs. 2005 Dec;23(6):533-7. Review.

PMID:
16267625
5.

Thymidylate synthase structure, function and implication in drug discovery.

Costi MP, Ferrari S, Venturelli A, Calò S, Tondi D, Barlocco D.

Curr Med Chem. 2005;12(19):2241-58. Review.

PMID:
16178783
6.

Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution.

Sampathkumar P, Turley S, Ulmer JE, Rhie HG, Sibley CH, Hol WG.

J Mol Biol. 2005 Oct 7;352(5):1091-104.

PMID:
16139296
7.

DNA and RNA synthesis: antifolates.

Kompis IM, Islam K, Then RL.

Chem Rev. 2005 Feb;105(2):593-620. Review. No abstract available.

PMID:
15700958
8.

Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase.

Griffin J, Roshick C, Iliffe-Lee E, McClarty G.

J Biol Chem. 2005 Feb 18;280(7):5456-67. Epub 2004 Dec 8.

9.

Functional analysis of FAD-dependent thymidylate synthase ThyX from Paramecium bursaria Chlorella virus-1.

Graziani S, Xia Y, Gurnon JR, Van Etten JL, Leduc D, Skouloubris S, Myllykallio H, Liebl U.

J Biol Chem. 2004 Dec 24;279(52):54340-7. Epub 2004 Oct 6.

10.
11.

Interactions of 5-deazapteridine derivatives with Mycobacterium tuberculosis and with human dihydrofolate reductases.

da Cunha EF, de Castro Ramalho T, Bicca de Alencastro R, Maia ER.

J Biomol Struct Dyn. 2004 Oct;22(2):119-30.

PMID:
15317473
12.

Mechanistic studies of a flavin-dependent thymidylate synthase.

Agrawal N, Lesley SA, Kuhn P, Kohen A.

Biochemistry. 2004 Aug 17;43(32):10295-301.

PMID:
15301527
13.

Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers.

Leduc D, Graziani S, Lipowski G, Marchand C, Le Maréchal P, Liebl U, Myllykallio H.

Proc Natl Acad Sci U S A. 2004 May 11;101(19):7252-7. Epub 2004 Apr 27.

14.

Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein.

Mathews II, Deacon AM, Canaves JM, McMullan D, Lesley SA, Agarwalla S, Kuhn P.

Structure. 2003 Jun;11(6):677-90.

15.

Life without dihydrofolate reductase FolA.

Myllykallio H, Leduc D, Filee J, Liebl U.

Trends Microbiol. 2003 May;11(5):220-3.

PMID:
12781525
16.

Genes required for mycobacterial growth defined by high density mutagenesis.

Sassetti CM, Boyd DH, Rubin EJ.

Mol Microbiol. 2003 Apr;48(1):77-84.

17.

Genetic evidence for a novel thymidylate synthase in the halophilic archaeon Halobacterium salinarum and in Campylobacter jejuni.

Giladi M, Bitan-Banin G, Mevarech M, Ortenberg R.

FEMS Microbiol Lett. 2002 Oct 29;216(1):105-9.

18.

Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase.

Gerum AB, Ulmer JE, Jacobus DP, Jensen NP, Sherman DR, Sibley CH.

Antimicrob Agents Chemother. 2002 Nov;46(11):3362-9.

19.

Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution.

Kuhn P, Lesley SA, Mathews II, Canaves JM, Brinen LS, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Hodgson KO, Jaroszewski L, Karlak C, Klock HE, Koesema E, Kovarik JM, Kreusch AT, McMullan D, McPhillips TM, Miller MA, Miller M, Morse A, Moy K, Ouyang J, Robb A, Rodrigues K, Selby TL, Spraggon G, Stevens RC, Taylor SS, van den Bedem H, Velasquez J, Vincent J, Wang X, West B, Wolf G, Wooley J, Wilson IA.

Proteins. 2002 Oct 1;49(1):142-5. No abstract available.

PMID:
12211025
20.

An alternative flavin-dependent mechanism for thymidylate synthesis.

Myllykallio H, Lipowski G, Leduc D, Filee J, Forterre P, Liebl U.

Science. 2002 Jul 5;297(5578):105-7. Epub 2002 May 23.

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