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Altered B:9-23 insulin, when administered intranasally with cholera toxin adjuvant, suppresses the expression of insulin autoantibodies and prevents diabetes.

Kobayashi M, Abiru N, Arakawa T, Fukushima K, Zhou H, Kawasaki E, Yamasaki H, Liu E, Miao D, Wong FS, Eisenbarth GS, Eguchi K.

J Immunol. 2007 Aug 15;179(4):2082-8.


Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity.

Nakayama M, Beilke JN, Jasinski JM, Kobayashi M, Miao D, Li M, Coulombe MG, Liu E, Elliott JF, Gill RG, Eisenbarth GS.

J Clin Invest. 2007 Jul;117(7):1835-43.


Screening for insulitis in adult autoantibody-positive organ donors.

In't Veld P, Lievens D, De Grijse J, Ling Z, Van der Auwera B, Pipeleers-Marichal M, Gorus F, Pipeleers D.

Diabetes. 2007 Sep;56(9):2400-4. Epub 2007 Jun 11.


The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form.

Levisetti MG, Suri A, Petzold SJ, Unanue ER.

J Immunol. 2007 May 15;178(10):6051-7.


CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes.

Mallone R, Martinuzzi E, Blancou P, Novelli G, Afonso G, Dolz M, Bruno G, Chaillous L, Chatenoud L, Bach JM, van Endert P.

Diabetes. 2007 Mar;56(3):613-21.


Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

Krishnamurthy B, Dudek NL, McKenzie MD, Purcell AW, Brooks AG, Gellert S, Colman PG, Harrison LC, Lew AM, Thomas HE, Kay TW.

J Clin Invest. 2006 Dec;116(12):3258-65.


Type 1 diabetes risk assessment: improvement by follow-up measurements in young islet autoantibody-positive relatives.

Achenbach P, Warncke K, Reiter J, Williams AJ, Ziegler AG, Bingley PJ, Bonifacio E.

Diabetologia. 2006 Dec;49(12):2969-76. Epub 2006 Sep 26.


Autoantibody markers for the diagnosis and prediction of type 1 diabetes.

Wasserfall CH, Atkinson MA.

Autoimmun Rev. 2006 Jul;5(6):424-8. Epub 2005 Dec 29. Review.


IgG(4)-mediated allergic reaction to glargine insulin.

Madero MF, Sastre J, Carnés J, Quirce S, Herrera-Pombo JL.

Allergy. 2006 Aug;61(8):1022-3. No abstract available.


TGF-beta signaling is required for the function of insulin-reactive T regulatory cells.

Du W, Wong FS, Li MO, Peng J, Qi H, Flavell RA, Sherwin R, Wen L.

J Clin Invest. 2006 May;116(5):1360-70. Erratum in: J Clin Invest. 2006 Jun;116(6):1738.


An immunologic homunculus for type 1 diabetes.

Homann D, Eisenbarth GS.

J Clin Invest. 2006 May;116(5):1212-5.


Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs.

Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone JA, Herold KC, von Herrath M.

J Clin Invest. 2006 May;116(5):1371-81. Epub 2006 Apr 20.


Intranasal vaccination with proinsulin DNA induces regulatory CD4+ T cells that prevent experimental autoimmune diabetes.

Every AL, Kramer DR, Mannering SI, Lew AM, Harrison LC.

J Immunol. 2006 Apr 15;176(8):4608-15.


T cell epitope mapping study with insulin overlapping peptides using ELISPOT assay in Japanese children and adolescents with type 1 diabetes.

Higashide T, Kawamura T, Nagata M, Kotani R, Kimura K, Hirose M, Inada H, Niihira S, Yamano T.

Pediatr Res. 2006 Mar;59(3):445-50.


Specific human leukocyte antigen DQ influence on expression of antiislet autoantibodies and progression to type 1 diabetes.

Redondo MJ, Babu S, Zeidler A, Orban T, Yu L, Greenbaum C, Palmer JP, Cuthbertson D, Eisenbarth GS, Krischer JP, Schatz D; Diabetes Prevention Trial Type 1 Study Group.

J Clin Endocrinol Metab. 2006 May;91(5):1705-13. Epub 2006 Feb 7.


[Insulin allergy: background, diagnosis and treatment].

Wonders J, Eekhoff EM, Heine R, Bruynzeel DP, Rustemeyer T.

Ned Tijdschr Geneeskd. 2005 Dec 10;149(50):2783-8. Review. Dutch.


Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes.

Pinkse GG, Tysma OH, Bergen CA, Kester MG, Ossendorp F, van Veelen PA, Keymeulen B, Pipeleers D, Drijfhout JW, Roep BO.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18425-30. Epub 2005 Dec 9.


GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects.

Oling V, Marttila J, Ilonen J, Kwok WW, Nepom G, Knip M, Simell O, Reijonen H.

J Autoimmun. 2005 Nov;25(3):235-43. Epub 2005 Nov 2. Erratum in: J Autoimmun. 2006 Aug;27(1):69.


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