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Items: 1 to 20 of 52

1.

Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans.

An G, Wei B, Xia B, McDaniel JM, Ju T, Cummings RD, Braun J, Xia L.

J Exp Med. 2007 Jun 11;204(6):1417-29. Epub 2007 May 21.

2.

IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease.

Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R.

J Immunol. 2007 May 1;178(9):5973-81.

3.

The fundamental basis of inflammatory bowel disease.

Strober W, Fuss I, Mannon P.

J Clin Invest. 2007 Mar;117(3):514-21. Review.

4.

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis.

Zheng Y, Danilenko DM, Valdez P, Kasman I, Eastham-Anderson J, Wu J, Ouyang W.

Nature. 2007 Feb 8;445(7128):648-51. Epub 2006 Dec 24.

PMID:
17187052
5.

Interleukin-17 is a negative regulator of established allergic asthma.

Schnyder-Candrian S, Togbe D, Couillin I, Mercier I, Brombacher F, Quesniaux V, Fossiez F, Ryffel B, Schnyder B.

J Exp Med. 2006 Nov 27;203(12):2715-25. Epub 2006 Nov 13.

6.

Cysteine-rich domains of muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing.

Ho SB, Dvorak LA, Moor RE, Jacobson AC, Frey MR, Corredor J, Polk DB, Shekels LL.

Gastroenterology. 2006 Nov;131(5):1501-17. Epub 2006 Sep 9.

PMID:
17101324
7.

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.

Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH.

Science. 2006 Dec 1;314(5804):1461-3. Epub 2006 Oct 26.

8.

IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

Kullberg MC, Jankovic D, Feng CG, Hue S, Gorelick PL, McKenzie BS, Cua DJ, Powrie F, Cheever AW, Maloy KJ, Sher A.

J Exp Med. 2006 Oct 30;203(11):2485-94. Epub 2006 Oct 9.

9.

Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis.

McVay LD, Keilbaugh SA, Wong TM, Kierstein S, Shin ME, Lehrke M, Lefterova MI, Shifflett DE, Barnes SL, Cominelli F, Cohn SM, Hecht G, Lazar MA, Haczku A, Wu GD.

J Clin Invest. 2006 Nov;116(11):2914-23. Epub 2006 Oct 5.

10.

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides.

Liang SC, Tan XY, Luxenberg DP, Karim R, Dunussi-Joannopoulos K, Collins M, Fouser LA.

J Exp Med. 2006 Oct 2;203(10):2271-9. Epub 2006 Sep 18.

11.

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

Uhlig HH, McKenzie BS, Hue S, Thompson C, Joyce-Shaikh B, Stepankova R, Robinson N, Buonocore S, Tlaskalova-Hogenova H, Cua DJ, Powrie F.

Immunity. 2006 Aug;25(2):309-18.

12.

Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.

Van der Sluis M, De Koning BA, De Bruijn AC, Velcich A, Meijerink JP, Van Goudoever JB, Büller HA, Dekker J, Van Seuningen I, Renes IB, Einerhand AW.

Gastroenterology. 2006 Jul;131(1):117-29.

PMID:
16831596
13.

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.

Yen D, Cheung J, Scheerens H, Poulet F, McClanahan T, McKenzie B, Kleinschek MA, Owyang A, Mattson J, Blumenschein W, Murphy E, Sathe M, Cua DJ, Kastelein RA, Rennick D.

J Clin Invest. 2006 May;116(5):1310-6.

14.

IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.

Wolk K, Witte E, Wallace E, Döcke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R.

Eur J Immunol. 2006 May;36(5):1309-23.

15.

IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration.

Brand S, Beigel F, Olszak T, Zitzmann K, Eichhorst ST, Otte JM, Diepolder H, Marquardt A, Jagla W, Popp A, Leclair S, Herrmann K, Seiderer J, Ochsenkühn T, Göke B, Auernhammer CJ, Dambacher J.

Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G827-38.

16.

Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts.

Andoh A, Zhang Z, Inatomi O, Fujino S, Deguchi Y, Araki Y, Tsujikawa T, Kitoh K, Kim-Mitsuyama S, Takayanagi A, Shimizu N, Fujiyama Y.

Gastroenterology. 2005 Sep;129(3):969-84.

PMID:
16143135
17.

Defects in mucosal immunity leading to ulcerative colitis.

Targan SR, Karp LC.

Immunol Rev. 2005 Aug;206:296-305. Review.

PMID:
16048556
18.
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20.

The IL-10R2 binding hot spot on IL-22 is located on the N-terminal helix and is dependent on N-linked glycosylation.

Logsdon NJ, Jones BC, Allman JC, Izotova L, Schwartz B, Pestka S, Walter MR.

J Mol Biol. 2004 Sep 10;342(2):503-14.

PMID:
15327950

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