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Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.

Chen BP, Uematsu N, Kobayashi J, Lerenthal Y, Krempler A, Yajima H, Löbrich M, Shiloh Y, Chen DJ.

J Biol Chem. 2007 Mar 2;282(9):6582-7. Epub 2006 Dec 21.


ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling.

Stiff T, Walker SA, Cerosaletti K, Goodarzi AA, Petermann E, Concannon P, O'Driscoll M, Jeggo PA.

EMBO J. 2006 Dec 13;25(24):5775-82. Epub 2006 Nov 23.


"ATR activation in response to ionizing radiation: still ATM territory".

Cuadrado M, Martinez-Pastor B, Fernandez-Capetillo O.

Cell Div. 2006 May 17;1(1):7.


Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

Zhao Y, Thomas HD, Batey MA, Cowell IG, Richardson CJ, Griffin RJ, Calvert AH, Newell DR, Smith GC, Curtin NJ.

Cancer Res. 2006 May 15;66(10):5354-62.


p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc.

Gladdy RA, Nutter LM, Kunath T, Danska JS, Guidos CJ.

Mol Cancer Res. 2006 May;4(5):311-8.


Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage.

Sturgeon CM, Knight ZA, Shokat KM, Roberge M.

Mol Cancer Ther. 2006 Apr;5(4):885-92.


The DNA repair complex DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy.

Salles B, Calsou P, Frit P, Muller C.

Pathol Biol (Paris). 2006 May;54(4):185-93. Epub 2006 Mar 23. Review.


ATM requirement in gene expression responses to ionizing radiation in human lymphoblasts and fibroblasts.

Innes CL, Heinloth AN, Flores KG, Sieber SO, Deming PB, Bushel PR, Kaufmann WK, Paules RS.

Mol Cancer Res. 2006 Mar;4(3):197-207.


Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex.

Adams KE, Medhurst AL, Dart DA, Lakin ND.

Oncogene. 2006 Jun 29;25(28):3894-904. Epub 2006 Feb 13.


ATM regulates ATR chromatin loading in response to DNA double-strand breaks.

Cuadrado M, Martinez-Pastor B, Murga M, Toledo LI, Gutierrez-Martinez P, Lopez E, Fernandez-Capetillo O.

J Exp Med. 2006 Feb 20;203(2):297-303. Epub 2006 Feb 6.


Rapid activation of ATR by ionizing radiation requires ATM and Mre11.

Myers JS, Cortez D.

J Biol Chem. 2006 Apr 7;281(14):9346-50. Epub 2006 Jan 23.


ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks.

Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP.

Nat Cell Biol. 2006 Jan;8(1):37-45. Epub 2005 Dec 4.


DNA damage checkpoints in mammals.

Niida H, Nakanishi M.

Mutagenesis. 2006 Jan;21(1):3-9. Epub 2005 Nov 28. Review.


The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.

Someya M, Sakata K, Matsumoto Y, Yamamoto H, Monobe M, Ikeda H, Ando K, Hosoi Y, Suzuki N, Hareyama M.

Carcinogenesis. 2006 Jan;27(1):117-22. Epub 2005 Jul 6.


DNA-dependent protein kinase is a molecular target for the development of noncytotoxic radiation-sensitizing drugs.

Shinohara ET, Geng L, Tan J, Chen H, Shir Y, Edwards E, Halbrook J, Kesicki EA, Kashishian A, Hallahan DE.

Cancer Res. 2005 Jun 15;65(12):4987-92.


ATM signaling and genomic stability in response to DNA damage.

Lavin MF, Birrell G, Chen P, Kozlov S, Scott S, Gueven N.

Mutat Res. 2005 Jan 6;569(1-2):123-32. Review.


Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage.

Santos JH, Meyer JN, Skorvaga M, Annab LA, Van Houten B.

Aging Cell. 2004 Dec;3(6):399-411.


Cell-cycle checkpoints and cancer.

Kastan MB, Bartek J.

Nature. 2004 Nov 18;432(7015):316-23. Review.


The ATM gene is a target for epigenetic silencing in locally advanced breast cancer.

Vo QN, Kim WJ, Cvitanovic L, Boudreau DA, Ginzinger DG, Brown KD.

Oncogene. 2004 Dec 16;23(58):9432-7. Erratum in: Oncogene. 2005 Mar 10;24(11):1964.


Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.

Zhang X, Succi J, Feng Z, Prithivirajsingh S, Story MD, Legerski RJ.

Mol Cell Biol. 2004 Oct;24(20):9207-20.

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