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Items: 1 to 20 of 119

2.
3.

The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity.

Miknyoczki S, Chang H, Grobelny J, Pritchard S, Worrell C, McGann N, Ator M, Husten J, Deibold J, Hudkins R, Zulli A, Parchment R, Ruggeri B.

Mol Cancer Ther. 2007 Aug;6(8):2290-302.

4.

XRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediates.

Mani RS, Fanta M, Karimi-Busheri F, Silver E, Virgen CA, Caldecott KW, Cass CE, Weinfeld M.

J Biol Chem. 2007 Sep 21;282(38):28004-13. Epub 2007 Jul 23.

5.

Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner.

Moser J, Kool H, Giakzidis I, Caldecott K, Mullenders LH, Fousteri MI.

Mol Cell. 2007 Jul 20;27(2):311-23.

6.

XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells.

Fan J, Wilson PF, Wong HK, Urbin SS, Thompson LH, Wilson DM 3rd.

Environ Mol Mutagen. 2007 Jul;48(6):491-500.

PMID:
17603793
7.

TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks.

El-Khamisy SF, Hartsuiker E, Caldecott KW.

DNA Repair (Amst). 2007 Oct 1;6(10):1485-95. Epub 2007 Jun 28.

PMID:
17600775
8.

Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends.

Takahashi T, Tada M, Igarashi S, Koyama A, Date H, Yokoseki A, Shiga A, Yoshida Y, Tsuji S, Nishizawa M, Onodera O.

Nucleic Acids Res. 2007;35(11):3797-809. Epub 2007 May 22.

9.

Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.

Thomas HD, Calabrese CR, Batey MA, Canan S, Hostomsky Z, Kyle S, Maegley KA, Newell DR, Skalitzky D, Wang LZ, Webber SE, Curtin NJ.

Mol Cancer Ther. 2007 Mar;6(3):945-56.

10.

Genetic variation in the base excision repair pathway and bladder cancer risk.

Figueroa JD, Malats N, Real FX, Silverman D, Kogevinas M, Chanock S, Welch R, Dosemeci M, Tardón A, Serra C, Carrato A, García-Closas R, Castaño-Vinyals G, Rothman N, García-Closas M.

Hum Genet. 2007 Apr;121(2):233-42. Epub 2007 Jan 3.

PMID:
17203305
11.

Polymorphisms of the DNA polymerase beta gene in breast cancer.

Sliwinski T, Ziemba P, Morawiec Z, Kowalski M, Zadrozny M, Blasiak J.

Breast Cancer Res Treat. 2007 Jun;103(2):161-6. Epub 2006 Nov 28.

PMID:
17131038
12.

Role for DNA polymerase beta in response to ionizing radiation.

Vermeulen C, Verwijs-Janssen M, Cramers P, Begg AC, Vens C.

DNA Repair (Amst). 2007 Feb 4;6(2):202-12. Epub 2006 Nov 28.

PMID:
17126614
13.

Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency.

Horton JK, Wilson SH.

DNA Repair (Amst). 2007 Apr 1;6(4):530-43. Epub 2006 Nov 20. Review.

14.

Radiation dose-rate effects, endogenous DNA damage, and signaling resonance.

Vilenchik MM, Knudson AG.

Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17874-9. Epub 2006 Nov 8.

15.

The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates.

Ahel I, Rass U, El-Khamisy SF, Katyal S, Clements PM, McKinnon PJ, Caldecott KW, West SC.

Nature. 2006 Oct 12;443(7112):713-6. Epub 2006 Sep 10.

PMID:
16964241
16.

Inhibition of poly(ADP-ribose) polymerase in cancer.

Plummer ER.

Curr Opin Pharmacol. 2006 Aug;6(4):364-8. Epub 2006 Jun 5. Review.

PMID:
16753340
17.
18.

XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage.

Lévy N, Martz A, Bresson A, Spenlehauer C, de Murcia G, Ménissier-de Murcia J.

Nucleic Acids Res. 2006 Jan 5;34(1):32-41. Print 2006.

19.

Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway.

Audebert M, Salles B, Weinfeld M, Calsou P.

J Mol Biol. 2006 Feb 17;356(2):257-65. Epub 2005 Nov 28.

PMID:
16364363
20.

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