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Items: 1 to 20 of 26


DNA double-strand break repair: from mechanistic understanding to cancer treatment.

Helleday T, Lo J, van Gent DC, Engelward BP.

DNA Repair (Amst). 2007 Jul 1;6(7):923-35. Epub 2007 Mar 23. Review.


Chromatin modifications and their function.

Kouzarides T.

Cell. 2007 Feb 23;128(4):693-705. Review.


Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.

Botuyan MV, Lee J, Ward IM, Kim JE, Thompson JR, Chen J, Mer G.

Cell. 2006 Dec 29;127(7):1361-73.


The tandem BRCT domain of 53BP1 is not required for its repair function.

Ward I, Kim JE, Minn K, Chini CC, Mer G, Chen J.

J Biol Chem. 2006 Dec 15;281(50):38472-7. Epub 2006 Oct 16.


Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks.

Lundin C, North M, Erixon K, Walters K, Jenssen D, Goldman AS, Helleday T.

Nucleic Acids Res. 2005 Jul 11;33(12):3799-811. Print 2005. Erratum in: Nucleic Acids Res. 2012 Jul;40(12):5794.


Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase.

Couture JF, Collazo E, Brunzelle JS, Trievel RC.

Genes Dev. 2005 Jun 15;19(12):1455-65. Epub 2005 Jun 2.


Specificity and mechanism of the histone methyltransferase Pr-Set7.

Xiao B, Jing C, Kelly G, Walker PA, Muskett FW, Frenkiel TA, Martin SR, Sarma K, Reinberg D, Gamblin SJ, Wilson JR.

Genes Dev. 2005 Jun 15;19(12):1444-54. Epub 2005 Jun 2.


Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage.

Syljuåsen RG, Sørensen CS, Hansen LT, Fugger K, Lundin C, Johansson F, Helleday T, Sehested M, Lukas J, Bartek J.

Mol Cell Biol. 2005 May;25(9):3553-62.


The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair.

Sørensen CS, Hansen LT, Dziegielewski J, Syljuåsen RG, Lundin C, Bartek J, Helleday T.

Nat Cell Biol. 2005 Feb;7(2):195-201. Epub 2005 Jan 23.


Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.

Huyen Y, Zgheib O, Ditullio RA Jr, Gorgoulis VG, Zacharatos P, Petty TJ, Sheston EA, Mellert HS, Stavridi ES, Halazonetis TD.

Nature. 2004 Nov 18;432(7015):406-11. Epub 2004 Nov 3.


A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication.

Pacek M, Walter JC.

EMBO J. 2004 Sep 15;23(18):3667-76. Epub 2004 Aug 26.


Replication protein A-mediated recruitment and activation of Rad17 complexes.

Zou L, Liu D, Elledge SJ.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13827-32. Epub 2003 Nov 6.


Characteristics of gamma-H2AX foci at DNA double-strand breaks sites.

Pilch DR, Sedelnikova OA, Redon C, Celeste A, Nussenzweig A, Bonner WM.

Biochem Cell Biol. 2003 Jun;81(3):123-9. Review.


Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou BB, Bartek J, Lukas J.

Cancer Cell. 2003 Mar;3(3):247-58.


Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes.

Rice JC, Nishioka K, Sarma K, Steward R, Reinberg D, Allis CD.

Genes Dev. 2002 Sep 1;16(17):2225-30.


Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase.

Fang J, Feng Q, Ketel CS, Wang H, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Simon JA, Zhang Y.

Curr Biol. 2002 Jul 9;12(13):1086-99.


PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin.

Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D.

Mol Cell. 2002 Jun;9(6):1201-13.

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