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The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.

Yan J, Kim YS, Yang XP, Li LP, Liao G, Xia F, Jetten AM.

Cancer Res. 2007 Jul 15;67(14):6647-56. Epub 2007 Jul 9.


Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.

Kim H, Chen J, Yu X.

Science. 2007 May 25;316(5828):1202-5.


RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.

Sobhian B, Shao G, Lilli DR, Culhane AC, Moreau LA, Xia B, Livingston DM, Greenberg RA.

Science. 2007 May 25;316(5828):1198-202.


Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.

Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ.

Science. 2007 May 25;316(5828):1194-8.


ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ.

Science. 2007 May 25;316(5828):1160-6.


A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.

Zhao GY, Sonoda E, Barber LJ, Oka H, Murakawa Y, Yamada K, Ikura T, Wang X, Kobayashi M, Yamamoto K, Boulton SJ, Takeda S.

Mol Cell. 2007 Mar 9;25(5):663-75.


DNA damage checkpoints: from initiation to recovery or adaptation.

Bartek J, Lukas J.

Curr Opin Cell Biol. 2007 Apr;19(2):238-45. Epub 2007 Feb 15. Review.


Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.

Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J.

J Cell Biol. 2006 Apr 24;173(2):195-206. Epub 2006 Apr 17.


MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.

Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J.

Mol Cell. 2006 Jan 20;21(2):187-200.


MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.

Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP.

Cell. 2005 Dec 29;123(7):1213-26. Erratum in: Cell. 2008 May 2;133(3):549.


The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation.

Plans V, Scheper J, Soler M, Loukili N, Okano Y, Thomson TM.

J Cell Biochem. 2006 Feb 15;97(3):572-82.


Production of endoribonuclease-prepared short interfering RNAs for gene silencing in mammalian cells.

Kittler R, Heninger AK, Franke K, Habermann B, Buchholz F.

Nat Methods. 2005 Oct;2(10):779-84. No abstract available.


Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail.

Lee MS, Edwards RA, Thede GL, Glover JN.

J Biol Chem. 2005 Sep 16;280(37):32053-6. Epub 2005 Jul 27.


Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1.

Bekker-Jensen S, Lukas C, Melander F, Bartek J, Lukas J.

J Cell Biol. 2005 Jul 18;170(2):201-11. Epub 2005 Jul 11.


Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.

Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NM, Orr AI, Reaper PM, Jackson SP, Curtin NJ, Smith GC.

Cancer Res. 2004 Dec 15;64(24):9152-9.


ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.

Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Löbrich M, Jeggo PA.

Cancer Res. 2004 Apr 1;64(7):2390-6.


The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains.

Bothos J, Summers MK, Venere M, Scolnick DM, Halazonetis TD.

Oncogene. 2003 Oct 16;22(46):7101-7.


Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.

Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A, Bonner RF, Bonner WM, Nussenzweig A.

Nat Cell Biol. 2003 Jul;5(7):675-9.


MDC1 is a mediator of the mammalian DNA damage checkpoint.

Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ.

Nature. 2003 Feb 27;421(6926):961-6.


MDC1 is required for the intra-S-phase DNA damage checkpoint.

Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, Bartek J, Jackson SP.

Nature. 2003 Feb 27;421(6926):952-6.


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