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Items: 1 to 20 of 38

1.

PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis.

Chen L, Iijima M, Tang M, Landree MA, Huang YE, Xiong Y, Iglesias PA, Devreotes PN.

Dev Cell. 2007 Apr;12(4):603-14.

2.

Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function.

Zhao T, Nalbant P, Hoshino M, Dong X, Wu D, Bokoch GM.

J Leukoc Biol. 2007 Apr;81(4):1127-36. Epub 2007 Jan 16.

PMID:
17227822
3.

PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis.

Ferguson GJ, Milne L, Kulkarni S, Sasaki T, Walker S, Andrews S, Crabbe T, Finan P, Jones G, Jackson S, Camps M, Rommel C, Wymann M, Hirsch E, Hawkins P, Stephens L.

Nat Cell Biol. 2007 Jan;9(1):86-91. Epub 2006 Dec 17.

PMID:
17173040
4.

PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?

Rückle T, Schwarz MK, Rommel C.

Nat Rev Drug Discov. 2006 Nov;5(11):903-18. Epub 2006 Oct 13. Review.

PMID:
17080027
5.

Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils.

Suire S, Condliffe AM, Ferguson GJ, Ellson CD, Guillou H, Davidson K, Welch H, Coadwell J, Turner M, Chilvers ER, Hawkins PT, Stephens L.

Nat Cell Biol. 2006 Nov;8(11):1303-9. Epub 2006 Oct 15.

PMID:
17041586
6.

Structural basis of function in heterotrimeric G proteins.

Oldham WM, Hamm HE.

Q Rev Biophys. 2006 May;39(2):117-66. Epub 2006 Aug 21. Review.

PMID:
16923326
7.

Differential targeting of Gbetagamma-subunit signaling with small molecules.

Bonacci TM, Mathews JL, Yuan C, Lehmann DM, Malik S, Wu D, Font JL, Bidlack JM, Smrcka AV.

Science. 2006 Apr 21;312(5772):443-6.

8.

Analyzing a kinetic titration series using affinity biosensors.

Karlsson R, Katsamba PS, Nordin H, Pol E, Myszka DG.

Anal Biochem. 2006 Feb 1;349(1):136-47. Epub 2005 Oct 13.

PMID:
16337141
9.

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

Camps M, Rückle T, Ji H, Ardissone V, Rintelen F, Shaw J, Ferrandi C, Chabert C, Gillieron C, Françon B, Martin T, Gretener D, Perrin D, Leroy D, Vitte PA, Hirsch E, Wymann MP, Cirillo R, Schwarz MK, Rommel C.

Nat Med. 2005 Sep;11(9):936-43. Epub 2005 Aug 28.

10.

PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus.

Barber DF, Bartolomé A, Hernandez C, Flores JM, Redondo C, Fernandez-Arias C, Camps M, Rückle T, Schwarz MK, Rodríguez S, Martinez-A C, Balomenos D, Rommel C, Carrera AC.

Nat Med. 2005 Sep;11(9):933-5. Epub 2005 Aug 28.

11.

Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression.

Posadas I, Bucci M, Roviezzo F, Rossi A, Parente L, Sautebin L, Cirino G.

Br J Pharmacol. 2004 May;142(2):331-8.

13.

Effects of valeryl salicylate, a COX-1 inhibitor, on models of acute inflammation in mice.

Siqueira-Junior JM, Peters RR, Brum-Fernandes AJ, Ribeiro-do-Valle RM.

Pharmacol Res. 2003 Nov;48(5):437-43.

PMID:
12967587
14.

CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11.

Xanthou G, Duchesnes CE, Williams TJ, Pease JE.

Eur J Immunol. 2003 Aug;33(8):2241-50.

15.

A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit.

Podolin PL, Bolognese BJ, Foley JJ, Schmidt DB, Buckley PT, Widdowson KL, Jin Q, White JR, Lee JM, Goodman RB, Hagen TR, Kajikawa O, Marshall LA, Hay DW, Sarau HM.

J Immunol. 2002 Dec 1;169(11):6435-44.

16.

A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responses.

Yang YF, Mukai T, Gao P, Yamaguchi N, Ono S, Iwaki H, Obika S, Imanishi T, Tsujimura T, Hamaoka T, Fujiwara H.

Eur J Immunol. 2002 Aug;32(8):2124-32.

17.
18.

The phosphoinositide 3-kinase pathway.

Cantley LC.

Science. 2002 May 31;296(5573):1655-7. Review.

PMID:
12040186
19.

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac.

Welch HC, Coadwell WJ, Ellson CD, Ferguson GJ, Andrews SR, Erdjument-Bromage H, Tempst P, Hawkins PT, Stephens LR.

Cell. 2002 Mar 22;108(6):809-21.

20.

AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice.

Matthys P, Hatse S, Vermeire K, Wuyts A, Bridger G, Henson GW, De Clercq E, Billiau A, Schols D.

J Immunol. 2001 Oct 15;167(8):4686-92.

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