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PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition.

Wang H, Quah SY, Dong JM, Manser E, Tang JP, Zeng Q.

Cancer Res. 2007 Apr 1;67(7):2922-6.


Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma.

Alsayed Y, Ngo H, Runnels J, Leleu X, Singha UK, Pitsillides CM, Spencer JA, Kimlinger T, Ghobrial JM, Jia X, Lu G, Timm M, Kumar A, Côté D, Veilleux I, Hedin KE, Roodman GD, Witzig TE, Kung AL, Hideshima T, Anderson KC, Lin CP, Ghobrial IM.

Blood. 2007 Apr 1;109(7):2708-17.


A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1.

Shaughnessy JD Jr, Zhan F, Burington BE, Huang Y, Colla S, Hanamura I, Stewart JP, Kordsmeier B, Randolph C, Williams DR, Xiao Y, Xu H, Epstein J, Anaissie E, Krishna SG, Cottler-Fox M, Hollmig K, Mohiuddin A, Pineda-Roman M, Tricot G, van Rhee F, Sawyer J, Alsayed Y, Walker R, Zangari M, Crowley J, Barlogie B.

Blood. 2007 Mar 15;109(6):2276-84. Epub 2006 Nov 14.


Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis.

Zhan F, Barlogie B, Arzoumanian V, Huang Y, Williams DR, Hollmig K, Pineda-Roman M, Tricot G, van Rhee F, Zangari M, Dhodapkar M, Shaughnessy JD Jr.

Blood. 2007 Feb 15;109(4):1692-700. Epub 2006 Oct 5.


Chemokines in multiple myeloma.

Aggarwal R, Ghobrial IM, Roodman GD.

Exp Hematol. 2006 Oct;34(10):1289-95. Review.


Inhibition of PRL-3 gene expression in gastric cancer cell line SGC7901 via microRNA suppressed reduces peritoneal metastasis.

Li Z, Zhan W, Wang Z, Zhu B, He Y, Peng J, Cai S, Ma J.

Biochem Biophys Res Commun. 2006 Sep 15;348(1):229-37. Epub 2006 Jul 18.


Overexpression of phosphatase of regenerating liver-3 in breast cancer: association with a poor clinical outcome.

Wang L, Peng L, Dong B, Kong L, Meng L, Yan L, Xie Y, Shou C.

Ann Oncol. 2006 Oct;17(10):1517-22. Epub 2006 Jul 27.


Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer.

Radke I, Götte M, Kersting C, Mattsson B, Kiesel L, Wülfing P.

Br J Cancer. 2006 Aug 7;95(3):347-54. Epub 2006 Jul 11.


The molecular classification of multiple myeloma.

Zhan F, Huang Y, Colla S, Stewart JP, Hanamura I, Gupta S, Epstein J, Yaccoby S, Sawyer J, Burington B, Anaissie E, Hollmig K, Pineda-Roman M, Tricot G, van Rhee F, Walker R, Zangari M, Crowley J, Barlogie B, Shaughnessy JD Jr.

Blood. 2006 Sep 15;108(6):2020-8. Epub 2006 May 25.


Expression of PRL proteins at invasive margin of rectal cancers in relation to preoperative radiotherapy.

Wallin AR, Svanvik J, Adell G, Sun XF.

Int J Radiat Oncol Biol Phys. 2006 Jun 1;65(2):452-8. Epub 2006 Apr 19.


PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility.

Fiordalisi JJ, Keller PJ, Cox AD.

Cancer Res. 2006 Mar 15;66(6):3153-61.


Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function.

Rouleau C, Roy A, St Martin T, Dufault MR, Boutin P, Liu D, Zhang M, Puorro-Radzwill K, Rulli L, Reczek D, Bagley R, Byrne A, Weber W, Roberts B, Klinger K, Brondyk W, Nacht M, Madden S, Burrier R, Shankara S, Teicher BA.

Mol Cancer Ther. 2006 Feb;5(2):219-29.


Identification of integrin alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3.

Peng L, Jin G, Wang L, Guo J, Meng L, Shou C.

Biochem Biophys Res Commun. 2006 Mar 31;342(1):179-83. Epub 2006 Feb 2.


PRL phosphatases as potential molecular targets in cancer.

Stephens BJ, Han H, Gokhale V, Von Hoff DD.

Mol Cancer Ther. 2005 Nov;4(11):1653-61. Review.


PRL-3 phosphatase is implicated in ovarian cancer growth.

Polato F, Codegoni A, Fruscio R, Perego P, Mangioni C, Saha S, Bardelli A, Broggini M.

Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6835-9.


Human myeloma cells adhere to fibronectin in response to hepatocyte growth factor.

Holt RU, Baykov V, Rø TB, Brabrand S, Waage A, Sundan A, Børset M.

Haematologica. 2005 Apr;90(4):479-88.


Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases.

Li J, Guo K, Koh VW, Tang JP, Gan BQ, Shi H, Li HX, Zeng Q.

Clin Cancer Res. 2005 Mar 15;11(6):2195-204.


DNA copy number changes at 8q11-24 in metastasized colorectal cancer.

Buffart TE, Coffa J, Hermsen MA, Carvalho B, van der Sijp JR, Ylstra B, Pals G, Schouten JP, Meijer GA.

Cell Oncol. 2005;27(1):57-65.


Alterations in vascular gene expression in invasive breast carcinoma.

Parker BS, Argani P, Cook BP, Liangfeng H, Chartrand SD, Zhang M, Saha S, Bardelli A, Jiang Y, St Martin TB, Nacht M, Teicher BA, Klinger KW, Sukumar S, Madden SL.

Cancer Res. 2004 Nov 1;64(21):7857-66. Erratum in: Cancer Res. 2004 Dec 1;64(23):8794.

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